Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma
Study Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of temozolomide plus lomustine followed by radiation therapy in treating patients who have high-grade malignant glioma.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 3 Years - 21 Years |
| Gender | All |
DISEASE CHARACTERISTICS:
- - Histologically confirmed high-grade malignant glioma of one of the following subtypes: - Glioblastoma.
- - Anaplastic astrocytoma.
- - Anaplastic oligoastrocytoma.
- - Gliomatosis cerebri.
- - No disseminated disease or primary spinal cord malignancies.
- - Measurable intracranial residual disease by MRI.
- - 3 and over.
- - Under 22 at time of diagnosis.
- - Karnofsky 50-100% if over 10 years of age.
- - Lansky 50-100% if 10 years of age or under.
- - At least 8 weeks.
- - Absolute neutrophil count at least 1,000/mm^3.
- - Platelet count at least 100,000/mm^3 (transfusion independent) - Hemoglobin at least 8.0 g/dL (RBC transfusions allowed) Hepatic: - Bilirubin no greater than 1.5 times normal for age.
- - SGPT no greater than 2.5 times normal for age.
- - Albumin at least 2 g/dL.
- - Creatinine no greater than 1.5 times normal for age OR.
- - Creatinine clearance or radioisotope glomerular filtration rate at least lower limit of normal for age.
- - No dyspnea at rest.
- - No exercise intolerance.
- - Pulse oximetry at least 94% Other: - Not pregnant or nursing.
- - Negative pregnancy test.
- - Fertile patients must use effective contraception.
- - No uncontrolled infection.
- - No prior biologic therapy.
- - No concurrent prophylactic hematopoietic growth factors.
- - No prior chemotherapy.
- - Prior corticosteroid therapy allowed.
- - No concurrent corticosteroids as antiemetic.
- - No prior radiotherapy.
- - No more than 31 days since prior maximal neurosurgical procedure.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00006024 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 1 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Children's Oncology Group |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Regina Jakacki, MD |
| Principal Investigator Affiliation | University of Pittsburgh |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Completed |
| Countries | Australia, Canada, Netherlands, New Zealand, Puerto Rico, Switzerland, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Brain Tumor, Central Nervous System Tumor |
OBJECTIVES:
- - Determine the maximum tolerated dose of temozolomide when administered with lomustine in patients with high-grade malignant gliomas.
- - Determine the dose-limiting toxic effects of this regimen in these patients.
- - Evaluate the feasibility of radiotherapy after this treatment regimen in this patient population.
- - Evaluate the radiographic responses in patients treated with this regimen.
Arms
Experimental: Pre and Post radiation Chemotherapy
Interventions
Drug: - lomustine
Drug: - temozolomide
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, 35233
Status
Address
University of South Alabama Medical Center
Mobile, Alabama, 36604
Status
Address
Phoenix Children's Hospital
Phoenix, Arizona, 85016-7710
Status
Address
Arizona Cancer Center
Tucson, Arizona, 85724
Status
Address
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Status
Address
Southern California Permanente Medical Group
Downey, California, 90242
Status
Address
City of Hope Comprehensive Cancer Center
Duarte, California, 91010-3000
Status
Address
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658
Status
Address
Loma Linda University Medical Center
Loma Linda, California, 92354
Status
Address
Jonathan Jaques Children's Cancer Center
Long Beach, California, 90801-1428
Status
Address
Children's Hospital Los Angeles
Los Angeles, California, 90027-0700
Status
Address
Cedars-Sinai Medical Center
Los Angeles, California, 90048
Status
Address
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
Status
Address
Children's Hospital Central California
Madera, California, 93638-8762
Status
Address
Children's Hospital of Oakland
Oakland, California, 94609-1809
Status
Address
Chao Family Comprehensive Cancer Center
Orange, California, 92868
Status
Address
Children's Hospital of Orange County
Orange, California, 92868
Status
Address
Lucile Packard Children's Hospital at Stanford
Palo Alto, California, 94304
Status
Address
Sutter Cancer Center
Sacramento, California, 95816
Status
Address
University of California Davis Medical Center
Sacramento, California, 95817
Status
Address
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
San Diego, California, 92120
Status
Address
Children's Hospital San Diego
San Diego, California, 92123-4282
Status
Address
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, 94115
Status
Address
UCSF Comprehensive Cancer Center
San Francisco, California, 94143-0128
Status
Address
Santa Barbara Cottage Hospital
Santa Barbara, California, 93102
Status
Address
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051-5386
Status
Address
David Grant Medical Center
Travis Air Force Base, California, 94535
Status
Address
Children's Hospital of Denver
Denver, Colorado, 80218-1088
Status
Address
Childhood Hematology/Oncology Associates
Denver, Colorado, 80218
Status
Address
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218
Status
Address
University of Connecticut Health Center
Farmington, Connecticut, 06360-7106
Status
Address
Yale Comprehensive Cancer Center
New Haven, Connecticut, 06520-8028
Status
Address
Alfred I. Dupont Institute
Wilmington, Delaware, 19899
Status
Address
Lombardi Cancer Center
Washington, District of Columbia, 20007
Status
Address
Children's National Medical Center
Washington, District of Columbia, 20010-2970
Status
Address
Walter Reed Army Medical Center
Washington, District of Columbia, 20307-5000
Status
Address
Broward General Medical Center
Fort Lauderdale, Florida, 33316
Status
Address
Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908
Status
Address
Shands Hospital and Clinics, University of Florida
Gainesville, Florida, 32610-100277
Status
Address
Joe DiMaggio Children's Hospital at Memorial
Hollywood, Florida, 33021
Status
Address
Nemours Children's Clinic
Jacksonville, Florida, 32207
Status
Address
University of Miami-Jackson Memorial Hospital
Miami, Florida, 33136
Status
Address
Miami Children's Hospital
Miami, Florida, 33155-4069
Status
Address
Baptist Hospital of Miami
Miami, Florida, 33176-2197
Status
Address
Florida Hospital Cancer Institute
Orlando, Florida, 32803
Status
Address
Nemours Children's Clinic-Orlando
Orlando, Florida, 32806
Status
Address
Sacred Heart Children's Hospital
Pensacola, Florida, 32504
Status
Address
All Children's Hospital
St. Petersburg, Florida, 33701
Status
Address
Tampa Children's Hospital
Tampa, Florida, 33677-4227
Status
Address
St. Mary's Hospital
West Palm Beach, Florida, 33407
Status
Address
Emory University Hospital - Atlanta
Atlanta, Georgia, 30322
Status
Address
Children's Healthcare of Atlanta - Scottish Rite
Atlanta, Georgia, 30342
Status
Address
Medical College of Georgia Comprehensive Cancer Center
Augusta, Georgia, 30912-4000
Status
Address
Medical Center of Central Georgia
Macon, Georgia, 31201
Status
Address
Memorial Health University Medical Center, Inc.
Savannah, Georgia, 31403-3089
Status
Address
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813
Status
Address
MBCCOP - Hawaii
Honolulu, Hawaii, 96813
Status
Address
Tripler Army Medical Center
Honolulu, Hawaii, 96859-5000
Status
Address
Mountain States Tumor Institute
Boise, Idaho, 83712
Status
Address
University of Chicago Cancer Research Center
Chicago, Illinois, 60601
Status
Address
Rush-Presbyterian-St. Luke's Medical Center
Chicago, Illinois, 60612
Status
Address
University of Illinois at Chicago
Chicago, Illinois, 60612
Status
Address
Children's Memorial Hospital - Chicago
Chicago, Illinois, 60614
Status
Address
Hope Children's Hospital
Oak Lawn, Illinois, 60453
Status
Address
Lutheran General Hospital
Park Ridge, Illinois, 60068-1174
Status
Address
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637
Status
Address
Southern Illinois University School of Medicine
Springfield, Illinois, 62794-9658
Status
Address
Indiana University Cancer Center
Indianapolis, Indiana, 46202-5289
Status
Address
St. Vincent Hospital and Health Care Center
Indianapolis, Indiana, 46260
Status
Address
Raymond Blank Memorial Hospital for Children
Des Moines, Iowa, 50308
Status
Address
John Stoddard Cancer Center
Des Moines, Iowa, 50309
Status
Address
Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242-1009
Status
Address
Wesley Medical Center
Wichita, Kansas, 67214
Status
Address
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, 40536-0284
Status
Address
Kosair Children's Hospital
Louisville, Kentucky, 40202-3830
Status
Address
Tulane University School of Medicine
New Orleans, Louisiana, 70112
Status
Address
Children's Hospital of New Orleans
New Orleans, Louisiana, 70118
Status
Address
Ochsner Clinic
New Orleans, Louisiana, 70121
Status
Address
Eastern Maine Medical Center
Bangor, Maine, 04401
Status
Address
Maine Children's Cancer Program
Scarborough, Maine, 04074
Status
Address
Marlene and Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201-1595
Status
Address
Sinai Hospital of Baltimore
Baltimore, Maryland, 21225
Status
Address
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231-2410
Status
Address
Floating Hospital for Children
Boston, Massachusetts, 02111
Status
Address
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115
Status
Address
Baystate Medical Center
Springfield, Massachusetts, 01107
Status
Address
University of Massachusetts Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655
Status
Address
Mott Children's Hospital
Ann Arbor, Michigan, 48109-0914
Status
Address
Children's Hospital of Michigan
Detroit, Michigan, 48201
Status
Address
Henry Ford Hospital
Detroit, Michigan, 48202
Status
Address
St. John Hospital and Medical Center
Detroit, Michigan, 48236
Status
Address
Michigan State University
East Lansing, Michigan, 48824
Status
Address
Hurley Medical Center
Flint, Michigan, 48503
Status
Address
Spectrum Health and DeVos Children's Hospital
Grand Rapids, Michigan, 49503
Status
Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
Status
Address
CCOP - Beaumont
Royal Oak, Michigan, 48073-6769
Status
Address
William Beaumont Hospital
Royal Oak, Michigan, 48073-6769
Status
Address
St. Mary's/Duluth Clinic Cancer Center
Duluth, Minnesota, 55805-1983
Status
Address
Children's Hospitals and Clinics - Minneapolis
Minneapolis, Minnesota, 55404
Status
Address
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905
Status
Address
Children's Hospitals and Clinics of Minnesota
Saint Paul, Minnesota, 55102
Status
Address
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505
Status
Address
Children's Mercy Hospital
Kansas City, Missouri, 64108
Status
Address
Cardinal Glennon Children's Hospital
Saint Louis, Missouri, 63104
Status
Address
St. Louis Children's Hospital
Saint Louis, Missouri, 63110
Status
Address
Children's Hospital of Omaha
Omaha, Nebraska, 68114
Status
Address
University of Nebraska Medical Center
Omaha, Nebraska, 68198-2168
Status
Address
Sunrise Hospital and Medical Center
Las Vegas, Nevada, 89109-2306
Status
Address
Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756-0002
Status
Address
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Status
Address
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
Status
Address
Newark Beth Israel Medical Center
Newark, New Jersey, 07112-2094
Status
Address
St. Joseph's Hospital and Medical Center
Paterson, New Jersey, 07503
Status
Address
Atlantic Health System
Summit, New Jersey, 07901
Status
Address
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, 87131
Status
Address
Cancer Center of Albany Medical Center
Albany, New York, 12208
Status
Address
Albert Einstein Clinical Cancer Center
Bronx, New York, 10461
Status
Address
Brooklyn Hospital Center
Brooklyn, New York, 11201
Status
Address
State University of New York Health Science Center at Brooklyn College of Medicine
Brooklyn, New York, 11203
Status
Address
Brookdale University Hospital and Medical Center
Brooklyn, New York, 11212
Status
Address
Maimonides Medical Center
Brooklyn, New York, 11219
Status
Address
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001
Status
Address
North Shore University Hospital
Manhasset, New York, 11030
Status
Address
Schneider Children's Hospital
New Hyde Park, New York, 11042
Status
Address
New York Presbyterian Hospital - Cornell Campus
New York, New York, 10021-4885
Status
Address
Memorial Sloan-Kettering Cancer Center
New York, New York, 10021
Status
Address
Mount Sinai School of Medicine
New York, New York, 10029
Status
Address
Columbia Presbyterian Hospital
New York, New York, 10032
Status
Address
James P. Wilmot Cancer Center
Rochester, New York, 14642
Status
Address
State University of New York Health Sciences Center - Stony Brook
Stony Brook, New York, 11790-7775
Status
Address
State University of New York - Upstate Medical University
Syracuse, New York, 13210
Status
Address
New York Medical College
Valhalla, New York, 10595
Status
Address
Mission Saint Joseph's Health System
Asheville, North Carolina, 28801
Status
Address
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295
Status
Address
Carolinas Medical Center
Charlotte, North Carolina, 28232-2861
Status
Address
Presbyterian Healthcare
Charlotte, North Carolina, 28233-3549
Status
Address
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
Status
Address
East Carolina University School of Medicine
Greenville, North Carolina, 27858-4354
Status
Address
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, 27157-1081
Status
Address
Dakota Cancer Institute
Fargo, North Dakota, 58103-4940
Status
Address
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308
Status
Address
Children's Hospital Medical Center - Cincinnati
Cincinnati, Ohio, 45229-3039
Status
Address
Ireland Cancer Center
Cleveland, Ohio, 44106-5065
Status
Address
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195
Status
Address
Children's Hospital of Columbus
Columbus, Ohio, 43205-2696
Status
Address
Children's Medical Center - Dayton
Dayton, Ohio, 45404
Status
Address
Toledo Children's Hospital
Toledo, Ohio, 43601
Status
Address
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608
Status
Address
Forum Health-Tod Childrens Hospital
Youngstown, Ohio, 44501
Status
Address
Children's Hospital of Oklahoma
Oklahoma City, Oklahoma, 73104
Status
Address
CCOP - Oklahoma
Tulsa, Oklahoma, 74136
Status
Address
Natalie Warren Bryant Cancer Center
Tulsa, Oklahoma, 74136
Status
Address
Doernbecher Children's Hospital
Portland, Oregon, 97201-3098
Status
Address
Legacy Emanuel Hospital and Health Center
Portland, Oregon, 97227
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822-1320
Status
Address
Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
Status
Address
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
Status
Address
St. Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134-1095
Status
Address
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213
Status
Address
Rhode Island Hospital
Providence, Rhode Island, 02818
Status
Address
Medical University of South Carolina
Charleston, South Carolina, 29425-0721
Status
Address
Palmetto Health South Carolina Cancer Center
Columbia, South Carolina, 29203
Status
Address
Children's Hospital of Greenville Hospital System
Greenville, South Carolina, 29605
Status
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57105-1080
Status
Address
Sioux Valley Hospital
Sioux Falls, South Dakota, 57117
Status
Address
East Tennessee State University Cancer Center at JCMC
Johnson City, Tennessee, 37604
Status
Address
East Tennessee Children's Hospital
Knoxville, Tennessee, 37901
Status
Address
Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105-2794
Status
Address
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232-6838
Status
Address
Texas Tech University Health Sciences Center School of Medicine
Amarillo, Texas, 79106
Status
Address
Children's Hospital of Austin
Austin, Texas, 78701
Status
Address
Medical City Dallas Hospital
Dallas, Texas, 75230
Status
Address
Simmons Cancer Center - Dallas
Dallas, Texas, 75235-9154
Status
Address
Cook Children's Medical Center - Fort Worth
Fort Worth, Texas, 76104
Status
Address
University of Texas Medical Branch
Galveston, Texas, 77555-0361
Status
Address
University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030-4009
Status
Address
Baylor College of Medicine
Houston, Texas, 77030
Status
Address
San Antonio Military Pediatric Cancer and Blood Disorders Center
Lackland Air Force Base, Texas, 78236-5300
Status
Address
Covenant Children's Hospital
Lubbock, Texas, 79410
Status
Address
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78207
Status
Address
Methodist Health Care System
San Antonio, Texas, 78229-3902
Status
Address
Scott and White Memorial Hospital
Temple, Texas, 76508
Status
Address
Huntsman Cancer Institute
Salt Lake City, Utah, 84112
Status
Address
Vermont Cancer Center
Burlington, Vermont, 05401-3498
Status
Address
Cancer Center at the University of Virginia
Charlottesville, Virginia, 22908
Status
Address
Inova Fairfax Hospital
Falls Church, Virginia, 22042-3300
Status
Address
Children's Hospital of the King's Daughters
Norfolk, Virginia, 23507
Status
Address
Naval Medical Center, Portsmouth
Portsmouth, Virginia, 23708-5100
Status
Address
Massey Cancer Center
Richmond, Virginia, 23298-0037
Status
Address
Carilion Medical Center for Children
Roanoke, Virginia, 24013
Status
Address
Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105
Status
Address
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024
Status
Address
Group Health Cooperative
Seattle, Washington, 98112
Status
Address
Deaconess Medical Center
Spokane, Washington, 99210-0248
Status
Address
Mary Bridge Children's Health Center
Tacoma, Washington, 98415-0299
Status
Address
Madigan Army Medical Center
Tacoma, Washington, 98431-5000
Status
Address
West Virginia University - Charleston
Charleston, West Virginia, 25302
Status
Address
Cabell-Huntington Hospital, Inc
Huntington, West Virginia, 25701
Status
Address
West Virginia University Hospitals
Morgantown, West Virginia, 26506-9300
Status
Address
Bellin Memorial Hospital
Green Bay, Wisconsin, 54301
Status
Address
CCOP - St. Vincent Hospital Cancer Center, Green Bay
Green Bay, Wisconsin, 54301
Status
Address
St. Vincent Hospital
Green Bay, Wisconsin, 54307-9070
Status
Address
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Address
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, 53792-0001
Status
Address
Marshfield Clinic
Marshfield, Wisconsin, 54449-5772
Status
Address
Midwest Children's Cancer Center
Milwaukee, Wisconsin, 53226
International Sites
Status
Address
Sydney Children's Hospital
Randwick, New South Wales, 2031
Status
Address
Children's Hospital at Westmead
Westmead, New South Wales, 2145
Status
Address
Royal Children's Hospital
Brisbane, Queensland, 4029
Status
Address
Women's and Children's Hospital
North Adelaide, South Australia, 5006
Status
Address
Royal Children's Hospital
Parkville, Victoria, 3052
Status
Address
Princess Margaret Hospital for Children
Perth, Western Australia, 6001
Status
Address
Alberta Children's Hospital
Calgary, Alberta, T2T 5C7
Status
Address
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2
Status
Address
British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4
Status
Address
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9
Status
Address
Janeway Children's Health and Rehabilitation Centre
St. John's, Newfoundland and Labrador, A1B 3V6
Status
Address
IWK Health Centre
Halifax, Nova Scotia, B3J 3G9
Status
Address
Children's Hospital
Hamilton, Ontario, L8N 3Z5
Status
Address
Children's Hospital of Western Ontario
London, Ontario, N6C 2V5
Status
Address
Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1
Status
Address
Hospital for Sick Children
Toronto, Ontario, M5G 1X8
Status
Address
McGill University Health Center - Montreal Children's Hospital
Montreal, Quebec, H3H 1P3
Status
Address
Hopital Sainte Justine
Montreal, Quebec, H3T 1C5
Status
Address
Centre Hospitalier de L'Universite Laval
Sainte Foy, Quebec, GIV 4G2
Status
Address
Laval University Medical Center
Sainte-Foy, Quebec, G1V 4G2
Status
Address
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1
Status
Address
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
Status
Address
Academisch Ziekenhuis Groningen
Groningen, , 9700 RB
Status
Address
Starship Children's Hospital
Auckland, ,
Status
Address
University of Puerto Rico School of Medicine Medical Sciences Campus
San Juan, , 00936-5067
Status
Address
San Jorge Childrens Hospital
Santurce, , 00912
Status
Address
Swiss Pediatric Oncology Group Bern
Bern, , CH 3010
Status
Address
Swiss Pediatric Oncology Group Geneva
Geneva, , CH 1211
Status
Address
Swiss Pediatric Oncology Group Lausanne
Lausanne, , CH 1011
