Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma
Study Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Giving chemotherapy together with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving chemotherapy together with radiation therapy after surgery followed by chemotherapy alone works in children with newly diagnosed astrocytoma, glioblastoma multiforme, gliosarcoma, or diffuse intrinsic pontine glioma.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 3 Years - 21 Years |
| Gender | All |
DISEASE CHARACTERISTICS:
- - Histologically confirmed newly diagnosed CNS tumor of the following types: - High grade glioma (HGG) of one of the following histologies: - Anaplastic astrocytoma (grade III) - Glioblastoma multiforme (grade IV) - Gliosarcoma.
- - Primary spinal cord malignant glioma.
- - Diffuse intrinsic pontine glioma (DIPG) - Diagnosed by gadolinium-enhanced MRI.
- - At least 2/3 of tumor situated in the pons AND tumor clearly originated in the pons.
- - No diffuse leptomeningeal disease.
- - No tumors with features not typical of diffuse intrinsic brainstem glioma, including any of the following: - Dorsally exophytic brainstem glioma.
- - Cervico-medullary junction tumor.
- - Focal low-grade glioma of the midbrain or brainstem.
- - No diffuse brainstem enlargement due to neurofibromatosis.
- - No primary brain stem malignant glioma.
- - No M+ disease (CSF positive for tumor or metastatic disease) - Must begin study radiotherapy within 6 weeks after surgical resection (for HGG patients) or diagnosis (for DIPG patients) PATIENT CHARACTERISTICS: Age: - 3 to 21.
- - Karnofsky 50-100% OR.
- - Lansky 50-100% Life expectancy: - At least 2 months.
- - Absolute neutrophil count at least 1,000/mm^3.
- - Platelet count at least 100,000/mm^3* - Hemoglobin at least 10.0 g/dL* NOTE: *Transfusion independent.
- - Bilirubin no greater than 1.5 times upper limit of normal (ULN) - SGOT or SGPT less than 2.5 times ULN.
- - Creatinine no greater than 1.5 times ULN.
- - No other concurrent malignancy.
- - Concurrent seizure disorder allowed if well controlled on anticonvulsants.
- - Not pregnant or nursing.
- - Negative pregnancy test.
- - Fertile patients must use effective contraception during and for 2 months after completion of study treatment.
- - No concurrent routine cytokine support.
- - Not specified.
- - No concurrent corticosteroids except for increased intracranial pressure in patients with CNS tumors.
- - See Disease Characteristics.
- - See Disease Characteristics.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00028795 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Children's Oncology Group |
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Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Kenneth J. Cohen, MD, MBA |
| Principal Investigator Affiliation | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Completed |
| Countries | Australia, Canada, Netherlands, New Zealand, Puerto Rico, Switzerland, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Brain and Central Nervous System Tumors |
OBJECTIVES:
- - Compare the event-free survival of patients with newly diagnosed anaplastic astrocytoma, glioblastoma multiforme, gliosarcoma, or diffuse intrinsic pontine glioma (DIPG) treated with adjuvant temozolomide administered concurrently with postoperative radiotherapy and then alone as maintenance therapy vs.#46;historical control cohorts treated in prior Pediatric Oncology Group and Children's Cancer Group studies.
- - Determine the toxicity of this regimen in these patients.
- - Determine the efficacy of this regimen in patients with DIPG.
- - Determine the toxicity of this regimen in patients with DIPG.
- - Adjuvant chemoradiotherapy: Beginning within 6 weeks after surgical resection or diagnosis*, patients without gross residual disease undergo cranial irradiation 5 days a week for 6 weeks.
- - Adjuvant maintenance therapy: Beginning 4 weeks after completion of adjuvant chemoradiotherapy, patients receive oral temozolomide on days 1-5.
Arms
Experimental: Chemoradiotherapy
Interventions
Drug: - temozolomide
Procedure: - adjuvant therapy
Radiation: - radiation therapy
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Van Elslander Cancer Center at St. John Hospital and Medical Center
Detroit, Michigan, 48236
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Address
Hurley Medical Center
Flint, Michigan, 48503
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Address
DeVos Children's Hospital
Grand Rapids, Michigan, 49503
Status
Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007-5364
Status
Address
Breslin Cancer Center at Ingham Regional Medical Center
Lansing, Michigan, 48910
Status
Address
William Beaumont Hospital - Royal Oak Campus
Royal Oak, Michigan, 48073-6769
Status
Address
St. Mary's - Duluth Clinic Cancer Center
Duluth, Minnesota, 55805
Status
Address
Children's Hospitals and Clinics - Minneapolis/St. Paul
Minneapolis, Minnesota, 55404
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Address
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905
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Address
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505
Status
Address
University of Missouri - Columbia
Columbia, Missouri, 65203
Status
Address
Children's Mercy Hospital
Kansas City, Missouri, 64108
Status
Address
Cardinal Glennon Children's Hospital
Saint Louis, Missouri, 63104
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Address
St. Louis Children's Hospital
Saint Louis, Missouri, 63110
Status
Address
Children's Hospital of Omaha
Omaha, Nebraska, 68114
Status
Address
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, 68198-2168
Status
Address
Nevada Cancer Research Foundation
Las Vegas, Nevada, 89109
Status
Address
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756
Status
Address
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Status
Address
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08903
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Address
Newark Beth Israel Medical Center
Newark, New Jersey, 07112-2094
Status
Address
St. Joseph's Hospital and Medical Center
Paterson, New Jersey, 07503
Status
Address
Valerie Fund Children's Center at Atlantic Health
Summit, New Jersey, 07901
Status
Address
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, 87131
Status
Address
Children's Hospital at Albany Medical Center
Albany, New York, 12208
Status
Address
Albert Einstein Cancer Center at Albert Einstein College of Medicine
Bronx, New York, 10461
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Address
Brooklyn Hospital Center
Brooklyn, New York, 11201-5493
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Address
SUNY Downstate Medical Center
Brooklyn, New York, 11203
Status
Address
Brookdale University Hospital and Medical Center
Brooklyn, New York, 11212
Status
Address
Comprehensive Cancer Center at Maimonides Medical Center
Brooklyn, New York, 11219
Status
Address
Schneider Children's Hospital
New Hyde Park, New York, 11040
Status
Address
Memorial Sloan-Kettering Cancer Center
New York, New York, 10021
Status
Address
New York Weill Cornell Cancer Center at Cornell University
New York, New York, 10021
Status
Address
Mount Sinai Medical Center
New York, New York, 10029
Status
Address
Herbert Irving Comprehensive Cancer Center at Columbia University
New York, New York, 10032
Status
Address
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642
Status
Address
Long Island Cancer Center at Stony Brook University Hospital
Stony Brook, New York, 11794-8174
Status
Address
SUNY Upstate Medical University Hospital
Syracuse, New York, 13210
Status
Address
New York Medical College
Valhalla, New York, 10595
Status
Address
Mission Hospitals - Memorial Campus
Asheville, North Carolina, 28801
Status
Address
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599
Status
Address
Blumenthal Cancer Center at Carolinas Medical Center
Charlotte, North Carolina, 28232-2861
Status
Address
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, 28233
Status
Address
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
Status
Address
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
Greenville, North Carolina, 27858-4354
Status
Address
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, 27157-1081
Status
Address
Dakota Cancer Institute at Innovis Health - Dakota Clinic
Fargo, North Dakota, 58103-4940
Status
Address
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308-1062
Status
Address
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3039
Status
Address
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
Cleveland, Ohio, 44106-5065
Status
Address
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195
Status
Address
Columbus Children's Hospital
Columbus, Ohio, 43205-2696
Status
Address
Children's Medical Center - Dayton
Dayton, Ohio, 45404
Status
Address
Toledo Children's Hospital
Toledo, Ohio, 43601
Status
Address
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608
Status
Address
Tod Children's Hospital - Forum Health
Youngstown, Ohio, 44501
Status
Address
Children's Hospital at Oklahoma University Medical Center
Oklahoma City, Oklahoma, 73104
Status
Address
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, 74136
Status
Address
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225
Status
Address
Legacy Emanuel Hospital and Health Center & Children's Hospital
Portland, Oregon, 97227
Status
Address
Doernbecher Children's Hospital at Oregon Health & Science University
Portland, Oregon, 97239-3098
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822-1320
Status
Address
Penn State Children's Hospital
Hershey, Pennsylvania, 17033
Status
Address
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
Status
Address
St. Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134-1095
Status
Address
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213
Status
Address
Rhode Island Hospital
Providence, Rhode Island, 02903
Status
Address
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425-0721
Status
Address
Palmetto Health South Carolina Cancer Center
Columbia, South Carolina, 29203
Status
Address
Children's Hospital of Greenville Hospital System
Greenville, South Carolina, 29605
Status
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57105-1080
Status
Address
Sioux Valley Hospital and University of South Dakota Medical Center
Sioux Falls, South Dakota, 57117-5039
Status
Address
East Tennessee State University Cancer Center at Johnson City Medical Center
Johnson City, Tennessee, 37614-0622
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Address
East Tennessee Children's Hospital
Knoxville, Tennessee, 37901
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Address
St. Jude Children's Research Hospital
Memphis, Tennessee, 38105
Status
Address
Vanderbilt Children's Hospital
Nashville, Tennessee, 37232-6310
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Address
Texas Tech University Health Sciences Center School of Medicine
Amarillo, Texas, 79106
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Address
Children's Hospital of Austin
Austin, Texas, 78701
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Address
Medical City Dallas Hospital
Dallas, Texas, 75230
Status
Address
Simmons Cancer Center at University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75390-9063
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Address
Cook Children's Medical Center - Fort Worth
Fort Worth, Texas, 76104
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Address
University of Texas Medical Branch
Galveston, Texas, 77555-0209
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Address
M.D. Anderson Cancer Center at University of Texas
Houston, Texas, 77030-4009
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Address
Baylor College of Medicine
Houston, Texas, 77030
Status
Address
San Antonio Military Pediatric Cancer and Blood Disorders Center
Lackland Air Force Base, Texas, 78236
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Address
Covenant Children's Hospital
Lubbock, Texas, 79410
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Address
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78207
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Address
MBCCOP - South Texas Pediatrics
San Antonio, Texas, 78229-3900
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Address
Methodist Cancer Center at Methodist Specialty and Transplant Hospital
San Antonio, Texas, 78229-3902
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Address
CCOP - Scott and White Hospital
Temple, Texas, 76508
Status
Address
Center for Cancer Prevention and Care at Scott and White Clinic
Temple, Texas, 76508
Status
Address
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, 84112
Status
Address
Vermont Cancer Center at University of Vermont
Burlington, Vermont, 05401-3498
Status
Address
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
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Address
INOVA Fairfax Hospital
Falls Church, Virginia, 22042-3300
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Address
Children's Hospital of the King's Daughters
Norfolk, Virginia, 23507
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Address
Naval Medical Center - Portsmouth
Portsmouth, Virginia, 23708-5100
Status
Address
Massey Cancer Center at Virginia Commonwealth University
Richmond, Virginia, 23298-0121
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Address
Carilion Medical Center for Children at Roanoke Community Hospital
Roanoke, Virginia, 24029
Status
Address
Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105
Status
Address
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024
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Address
Group Health Central Hospital
Seattle, Washington, 98112
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Address
Deaconess Medical Center
Spokane, Washington, 99210-0248
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Address
Mary Bridge Children's Hospital and Health Center - Tacoma
Tacoma, Washington, 98415-0299
Status
Address
Madigan Army Medical Center
Tacoma, Washington, 98431-0001
Status
Address
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
Charleston, West Virginia, 25302
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Address
Cabell Huntington Hospital
Huntington, West Virginia, 25701
Status
Address
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Morgantown, West Virginia, 26506-9300
Status
Address
Bellin Memorial Hospital
Green Bay, Wisconsin, 54301
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Address
CCOP - St. Vincent Hospital Cancer Center, Green Bay
Green Bay, Wisconsin, 54301
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Address
St. Vincent Hospital
Green Bay, Wisconsin, 54307-9070
Status
Address
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Address
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164
Status
Address
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, 54449-5772
Status
Address
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, 54449
Status
Address
Midwest Children's Cancer Center
Milwaukee, Wisconsin, 53226
Status
Address
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital
Long Beach, California, 90801-1428
Status
Address
Children's Hospital Los Angeles
Los Angeles, California, 90027-0700
Status
Address
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
Los Angeles, California, 90048
Status
Address
Jonsson Comprehensive Cancer Center at UCLA
Los Angeles, California, 90095-1781
Status
Address
Children's Hospital Central California
Madera, California, 93638-8762
Status
Address
Children's Hospital and Research Center at Oakland
Oakland, California, 94609-1809
Status
Address
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
Orange, California, 92868
Status
Address
Children's Hospital of Orange County
Orange, California, 92868
Status
Address
Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304
Status
Address
Sutter Cancer Center
Sacramento, California, 95816
Status
Address
University of California Davis Cancer Center
Sacramento, California, 95817
Status
Address
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, 95825
Status
Address
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
San Diego, California, 92120
Status
Address
Children's Hospital and Health Center - San Diego
San Diego, California, 92123-4282
Status
Address
UCSF Comprehensive Cancer Center
San Francisco, California, 94143
Status
Address
Santa Barbara Cottage Hospital
Santa Barbara, California, 93102
Status
Address
Kaiser Permanente Medical Center - Santa Clara Kiely Campus
Santa Clara, California, 95051-5386
Status
Address
General Robert Huyser Cancer Center at David Grant Medical Center
Travis Air Force Base, California, 94535
Status
Address
Children's Hospital Cancer Center
Denver, Colorado, 80218
Status
Address
Presbyterian - St. Luke's Medical Center
Denver, Colorado, 80218
Status
Address
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
Farmington, Connecticut, 06360-7106
Status
Address
Yale Comprehensive Cancer Center
New Haven, Connecticut, 06520-8064
Status
Address
Alfred I. duPont Hospital for Children
Wilmington, Delaware, 19899
Status
Address
Lombardi Cancer Center at Georgetown University Medical Center
Washington, District of Columbia, 20007
Status
Address
Children's National Medical Center
Washington, District of Columbia, 20010-2970
Status
Address
Broward General Medical Center
Fort Lauderdale, Florida, 33316
Status
Address
Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908
Status
Address
University of Florida Shands Cancer Center
Gainesville, Florida, 32610-0296
Status
Address
Joe DiMaggio Children's Hospital at Memorial
Hollywood, Florida, 33021
Status
Address
Nemours Children's Clinic
Jacksonville, Florida, 32207
Status
Address
Jackson Memorial Hospital
Miami, Florida, 33136
Status
Address
Miami Children's Hospital
Miami, Florida, 33155
Status
Address
Baptist-South Miami Regional Cancer Program
Miami, Florida, 33176-2197
Status
Address
Florida Hospital Cancer Institute
Orlando, Florida, 32804
Status
Address
Nemours Children's Clinic-Orlando
Orlando, Florida, 32806
Status
Address
Sacred Heart Children's Hospital
Pensacola, Florida, 32504
Status
Address
All Children's Hospital
St. Petersburg, Florida, 33701
Status
Address
St. Joseph's Children's Hospital of Tampa
Tampa, Florida, 33677-4227
Status
Address
Kaplan Cancer Center at St. Mary's Medical Center
West Palm Beach, Florida, 33407
Status
Address
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus
Atlanta, Georgia, 30342
Status
Address
MBCCOP-Medical College of Georgia Cancer Center
Augusta, Georgia, 30912-4000
Status
Address
Medical Center of Central Georgia
Macon, Georgia, 31201
Status
Address
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, 31405
Status
Address
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813
Status
Address
Tripler Army Medical Center
Honolulu, Hawaii, 96859-5000
Status
Address
St. Luke's Mountain States Tumor Institute - Boise
Boise, Idaho, 83712
Status
Address
University of Chicago Cancer Research Center
Chicago, Illinois, 60601
Status
Address
Rush University Medical Center
Chicago, Illinois, 60612
Status
Address
University of Illinois Medical Center
Chicago, Illinois, 60612
Status
Address
Children's Memorial Hospital - Chicago
Chicago, Illinois, 60614
Status
Address
Advocate Hope Children's Hospital
Oak Lawn, Illinois, 60453
Status
Address
Lutheran General Cancer Care Center
Park Ridge, Illinois, 60068-1174
Status
Address
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637
Status
Address
Southern Illinois University School of Medicine
Springfield, Illinois, 62794-9658
Status
Address
Riley Children Cancer Center at Riley Hospital for Children
Indianapolis, Indiana, 46202-5225
Status
Address
St. Vincent Hospitals and Health Care Centers
Indianapolis, Indiana, 46260
Status
Address
Blank Children's Hospital
Des Moines, Iowa, 50309
Status
Address
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, 52242-1009
Status
Address
Wesley Medical Center
Wichita, Kansas, 67214
Status
Address
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, 40536-0284
Status
Address
Kosair Children's Hospital
Louisville, Kentucky, 40202-3830
Status
Address
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112
Status
Address
Tulane Cancer Center at Tulane University Hospital and Clinic
New Orleans, Louisiana, 70112
Status
Address
Children's Hospital of New Orleans
New Orleans, Louisiana, 70118
Status
Address
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, 70121
Status
Address
Pediatric Specialty Clinic at Eastern Maine Medical Center
Bangor, Maine, 04401
Status
Address
Maine Children's Cancer Program
Scarborough, Maine, 04074-9308
Status
Address
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, 21201-1595
Status
Address
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
Baltimore, Maryland, 21215
Status
Address
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231-7223
Status
Address
Walter Reed Army Medical Center
Silver Spring, Maryland, 20910
Status
Address
Floating Hospital for Children
Boston, Massachusetts, 02111
Status
Address
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, 02115
Status
Address
Baystate Regional Cancer Program at D'Amour Center for Cancer Care
Springfield, Massachusetts, 01107
Status
Address
UMASS Memorial Cancer Center - University Campus
Worcester, Massachusetts, 01655
Status
Address
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0914
Status
Address
Children's Hospital of Michigan
Detroit, Michigan, 48201
Status
Address
Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham, Alabama, 35233
Status
Address
University of South Alabama Cancer Research Institute
Mobile, Alabama, 36604
Status
Address
Phoenix Children's Hospital
Phoenix, Arizona, 85016
Status
Address
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, 85724
Status
Address
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Status
Address
Southern California Permanente Medical Group
Downey, California, 90242
Status
Address
City of Hope Comprehensive Cancer Center
Duarte, California, 91010-3000
Status
Address
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658
Status
Address
Loma Linda University Cancer Institute at Loma Linda University Medical Center
Loma Linda, California, 92354
International Sites
Status
Address
Sydney Children's Hospital
Randwick, New South Wales, 2031
Status
Address
Children's Hospital at Westmead
Westmead, New South Wales, 2145
Status
Address
Royal Children's Hospital
Brisbane, Queensland, 4029
Status
Address
Women's and Children's Hospital
North Adelaide, South Australia, 5006
Status
Address
Royal Children's Hospital
Parkville, Victoria, 3052
Status
Address
Princess Margaret Hospital for Children
Perth, Western Australia, 6001
Status
Address
Alberta Children's Hospital
Calgary, Alberta, T2T 5C7
Status
Address
Cross Cancer Institute at University of Alberta
Edmonton, Alberta, T6G 1Z2
Status
Address
British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4
Status
Address
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9
Status
Address
Janeway Children's Health and Rehabilitation Centre
St. John's, Newfoundland and Labrador, A1B 3V6
Status
Address
IWK Health Centre
Halifax, Nova Scotia, B3J 3G9
Status
Address
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton, Ontario, L8S 4J9
Status
Address
Children's Hospital of Western Ontario
London, Ontario, N6C 2V5
Status
Address
Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1
Status
Address
Hospital for Sick Children
Toronto, Ontario, M5G 1X8
Status
Address
Montreal Children's Hospital at McGill University Health Center
Montreal, Quebec, H3G 1A4
Status
Address
Hopital Sainte Justine
Montreal, Quebec, H3T 1C5
Status
Address
Centre de Recherche du Centre Hospitalier de l'Universite Laval
Sainte Foy, Quebec, GIV 4G2
Status
Address
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, S4T 7T1
Status
Address
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
Status
Address
University Medical Center Groningen
Groningen, , 9700 RB
Status
Address
Starship Children's Health
Auckland, ,
Status
Address
Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus
San Juan, , 00936-5067
Status
Address
San Jorge Children's Hospital
Santurce, , 00912
Status
Address
Swiss Pediatric Oncology Group Bern
Bern, , CH 3010
Status
Address
Swiss Pediatric Oncology Group Geneva
Geneva, , CH 1211
Status
Address
Swiss Pediatric Oncology Group Lausanne
Lausanne, , CH 1011
