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Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma

Study Purpose

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Giving chemotherapy together with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving chemotherapy together with radiation therapy after surgery followed by chemotherapy alone works in children with newly diagnosed astrocytoma, glioblastoma multiforme, gliosarcoma, or diffuse intrinsic pontine glioma.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 3 Years - 21 Years
Gender All
More Inclusion & Exclusion Criteria

DISEASE CHARACTERISTICS:

  • - Histologically confirmed newly diagnosed CNS tumor of the following types: - High grade glioma (HGG) of one of the following histologies: - Anaplastic astrocytoma (grade III) - Glioblastoma multiforme (grade IV) - Gliosarcoma.
  • - Primary spinal cord malignant glioma.
  • - Diffuse intrinsic pontine glioma (DIPG) - Diagnosed by gadolinium-enhanced MRI.
  • - At least 2/3 of tumor situated in the pons AND tumor clearly originated in the pons.
  • - No diffuse leptomeningeal disease.
  • - No tumors with features not typical of diffuse intrinsic brainstem glioma, including any of the following: - Dorsally exophytic brainstem glioma.
  • - Cervico-medullary junction tumor.
  • - Focal low-grade glioma of the midbrain or brainstem.
  • - No diffuse brainstem enlargement due to neurofibromatosis.
  • - No primary brain stem malignant glioma.
  • - No M+ disease (CSF positive for tumor or metastatic disease) - Must begin study radiotherapy within 6 weeks after surgical resection (for HGG patients) or diagnosis (for DIPG patients) PATIENT CHARACTERISTICS: Age: - 3 to 21.
Performance status:
  • - Karnofsky 50-100% OR.
  • - Lansky 50-100% Life expectancy: - At least 2 months.
Hematopoietic:
  • - Absolute neutrophil count at least 1,000/mm^3.
  • - Platelet count at least 100,000/mm^3* - Hemoglobin at least 10.0 g/dL* NOTE: *Transfusion independent.
Hepatic:
  • - Bilirubin no greater than 1.5 times upper limit of normal (ULN) - SGOT or SGPT less than 2.5 times ULN.
Renal:
  • - Creatinine no greater than 1.5 times ULN.
Other:
  • - No other concurrent malignancy.
  • - Concurrent seizure disorder allowed if well controlled on anticonvulsants.
  • - Not pregnant or nursing.
  • - Negative pregnancy test.
  • - Fertile patients must use effective contraception during and for 2 months after completion of study treatment.
PRIOR CONCURRENT THERAPY: Biologic:
  • - No concurrent routine cytokine support.
Chemotherapy:
  • - Not specified.
Endocrine therapy:
  • - No concurrent corticosteroids except for increased intracranial pressure in patients with CNS tumors.
Radiotherapy:
  • - See Disease Characteristics.
Surgery:
  • - See Disease Characteristics.
Other: - No prior therapy for HGG or DIPG

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT00028795
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Children's Oncology Group
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Kenneth J. Cohen, MD, MBA
Principal Investigator Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other, NIH
Overall Status Completed
Countries Australia, Canada, Netherlands, New Zealand, Puerto Rico, Switzerland, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Brain and Central Nervous System Tumors
Additional Details

OBJECTIVES:

  • - Compare the event-free survival of patients with newly diagnosed anaplastic astrocytoma, glioblastoma multiforme, gliosarcoma, or diffuse intrinsic pontine glioma (DIPG) treated with adjuvant temozolomide administered concurrently with postoperative radiotherapy and then alone as maintenance therapy vs.#46;historical control cohorts treated in prior Pediatric Oncology Group and Children's Cancer Group studies.
  • - Determine the toxicity of this regimen in these patients.
  • - Determine the efficacy of this regimen in patients with DIPG.
  • - Determine the toxicity of this regimen in patients with DIPG.
OUTLINE: This is a multicenter study.
  • - Adjuvant chemoradiotherapy: Beginning within 6 weeks after surgical resection or diagnosis*, patients without gross residual disease undergo cranial irradiation 5 days a week for 6 weeks.
Beginning within 6 weeks after surgical resection, patients with gross residual disease undergo radiotherapy as above followed by boost radiotherapy for 1 week. All patients receive oral temozolomide once daily beginning within 5 days after initiation of radiotherapy and continuing for a total of 6 weeks in the absence of disease progression or unacceptable toxicity.
  • - Adjuvant maintenance therapy: Beginning 4 weeks after completion of adjuvant chemoradiotherapy, patients receive oral temozolomide on days 1-5.
Treatment repeats every 28 days for a total of 10 courses in the absence of disease progression or unacceptable toxicity. NOTE: *For patients with diffuse intrinsic pontine glioma only.Patients are followed every 3-6 months for 4 years and then annually thereafter. PROJECTED ACCRUAL: A total of 50-60 patients will be accrued for this study within 12-14 months.

Arms & Interventions

Arms

Experimental: Chemoradiotherapy

Interventions

Drug: - temozolomide

Procedure: - adjuvant therapy

Radiation: - radiation therapy

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Detroit, Michigan

Status

Address

Van Elslander Cancer Center at St. John Hospital and Medical Center

Detroit, Michigan, 48236

Hurley Medical Center, Flint, Michigan

Status

Address

Hurley Medical Center

Flint, Michigan, 48503

DeVos Children's Hospital, Grand Rapids, Michigan

Status

Address

DeVos Children's Hospital

Grand Rapids, Michigan, 49503

Bronson Methodist Hospital, Kalamazoo, Michigan

Status

Address

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007-5364

Lansing, Michigan

Status

Address

Breslin Cancer Center at Ingham Regional Medical Center

Lansing, Michigan, 48910

Royal Oak, Michigan

Status

Address

William Beaumont Hospital - Royal Oak Campus

Royal Oak, Michigan, 48073-6769

St. Mary's - Duluth Clinic Cancer Center, Duluth, Minnesota

Status

Address

St. Mary's - Duluth Clinic Cancer Center

Duluth, Minnesota, 55805

Minneapolis, Minnesota

Status

Address

Children's Hospitals and Clinics - Minneapolis/St. Paul

Minneapolis, Minnesota, 55404

Mayo Clinic Cancer Center, Rochester, Minnesota

Status

Address

Mayo Clinic Cancer Center

Rochester, Minnesota, 55905

University of Mississippi Medical Center, Jackson, Mississippi

Status

Address

University of Mississippi Medical Center

Jackson, Mississippi, 39216-4505

University of Missouri - Columbia, Columbia, Missouri

Status

Address

University of Missouri - Columbia

Columbia, Missouri, 65203

Children's Mercy Hospital, Kansas City, Missouri

Status

Address

Children's Mercy Hospital

Kansas City, Missouri, 64108

Cardinal Glennon Children's Hospital, Saint Louis, Missouri

Status

Address

Cardinal Glennon Children's Hospital

Saint Louis, Missouri, 63104

St. Louis Children's Hospital, Saint Louis, Missouri

Status

Address

St. Louis Children's Hospital

Saint Louis, Missouri, 63110

Children's Hospital of Omaha, Omaha, Nebraska

Status

Address

Children's Hospital of Omaha

Omaha, Nebraska, 68114

Omaha, Nebraska

Status

Address

UNMC Eppley Cancer Center at the University of Nebraska Medical Center

Omaha, Nebraska, 68198-2168

Nevada Cancer Research Foundation, Las Vegas, Nevada

Status

Address

Nevada Cancer Research Foundation

Las Vegas, Nevada, 89109

Lebanon, New Hampshire

Status

Address

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756

Hackensack University Medical Center, Hackensack, New Jersey

Status

Address

Hackensack University Medical Center

Hackensack, New Jersey, 07601

New Brunswick, New Jersey

Status

Address

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

New Brunswick, New Jersey, 08903

Newark Beth Israel Medical Center, Newark, New Jersey

Status

Address

Newark Beth Israel Medical Center

Newark, New Jersey, 07112-2094

St. Joseph's Hospital and Medical Center, Paterson, New Jersey

Status

Address

St. Joseph's Hospital and Medical Center

Paterson, New Jersey, 07503

Summit, New Jersey

Status

Address

Valerie Fund Children's Center at Atlantic Health

Summit, New Jersey, 07901

Albuquerque, New Mexico

Status

Address

University of New Mexico Cancer Research and Treatment Center

Albuquerque, New Mexico, 87131

Albany, New York

Status

Address

Children's Hospital at Albany Medical Center

Albany, New York, 12208

Bronx, New York

Status

Address

Albert Einstein Cancer Center at Albert Einstein College of Medicine

Bronx, New York, 10461

Brooklyn Hospital Center, Brooklyn, New York

Status

Address

Brooklyn Hospital Center

Brooklyn, New York, 11201-5493

SUNY Downstate Medical Center, Brooklyn, New York

Status

Address

SUNY Downstate Medical Center

Brooklyn, New York, 11203

Brooklyn, New York

Status

Address

Brookdale University Hospital and Medical Center

Brooklyn, New York, 11212

Brooklyn, New York

Status

Address

Comprehensive Cancer Center at Maimonides Medical Center

Brooklyn, New York, 11219

Schneider Children's Hospital, New Hyde Park, New York

Status

Address

Schneider Children's Hospital

New Hyde Park, New York, 11040

Memorial Sloan-Kettering Cancer Center, New York, New York

Status

Address

Memorial Sloan-Kettering Cancer Center

New York, New York, 10021

New York, New York

Status

Address

New York Weill Cornell Cancer Center at Cornell University

New York, New York, 10021

Mount Sinai Medical Center, New York, New York

Status

Address

Mount Sinai Medical Center

New York, New York, 10029

New York, New York

Status

Address

Herbert Irving Comprehensive Cancer Center at Columbia University

New York, New York, 10032

Rochester, New York

Status

Address

James P. Wilmot Cancer Center at University of Rochester Medical Center

Rochester, New York, 14642

Stony Brook, New York

Status

Address

Long Island Cancer Center at Stony Brook University Hospital

Stony Brook, New York, 11794-8174

SUNY Upstate Medical University Hospital, Syracuse, New York

Status

Address

SUNY Upstate Medical University Hospital

Syracuse, New York, 13210

New York Medical College, Valhalla, New York

Status

Address

New York Medical College

Valhalla, New York, 10595

Mission Hospitals - Memorial Campus, Asheville, North Carolina

Status

Address

Mission Hospitals - Memorial Campus

Asheville, North Carolina, 28801

Chapel Hill, North Carolina

Status

Address

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

Chapel Hill, North Carolina, 27599

Charlotte, North Carolina

Status

Address

Blumenthal Cancer Center at Carolinas Medical Center

Charlotte, North Carolina, 28232-2861

Charlotte, North Carolina

Status

Address

Presbyterian Cancer Center at Presbyterian Hospital

Charlotte, North Carolina, 28233

Duke Comprehensive Cancer Center, Durham, North Carolina

Status

Address

Duke Comprehensive Cancer Center

Durham, North Carolina, 27710

Greenville, North Carolina

Status

Address

Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital

Greenville, North Carolina, 27858-4354

Winston-Salem, North Carolina

Status

Address

Comprehensive Cancer Center at Wake Forest University

Winston-Salem, North Carolina, 27157-1081

Fargo, North Dakota

Status

Address

Dakota Cancer Institute at Innovis Health - Dakota Clinic

Fargo, North Dakota, 58103-4940

Akron, Ohio

Status

Address

Children's Hospital Medical Center of Akron

Akron, Ohio, 44308-1062

Cincinnati, Ohio

Status

Address

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229-3039

Cleveland, Ohio

Status

Address

Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University

Cleveland, Ohio, 44106-5065

Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

Status

Address

Cleveland Clinic Taussig Cancer Center

Cleveland, Ohio, 44195

Columbus Children's Hospital, Columbus, Ohio

Status

Address

Columbus Children's Hospital

Columbus, Ohio, 43205-2696

Children's Medical Center - Dayton, Dayton, Ohio

Status

Address

Children's Medical Center - Dayton

Dayton, Ohio, 45404

Toledo Children's Hospital, Toledo, Ohio

Status

Address

Toledo Children's Hospital

Toledo, Ohio, 43601

St. Vincent Mercy Medical Center, Toledo, Ohio

Status

Address

St. Vincent Mercy Medical Center

Toledo, Ohio, 43608

Tod Children's Hospital - Forum Health, Youngstown, Ohio

Status

Address

Tod Children's Hospital - Forum Health

Youngstown, Ohio, 44501

Oklahoma City, Oklahoma

Status

Address

Children's Hospital at Oklahoma University Medical Center

Oklahoma City, Oklahoma, 73104

Tulsa, Oklahoma

Status

Address

Natalie Warren Bryant Cancer Center at St. Francis Hospital

Tulsa, Oklahoma, 74136

CCOP - Columbia River Oncology Program, Portland, Oregon

Status

Address

CCOP - Columbia River Oncology Program

Portland, Oregon, 97225

Portland, Oregon

Status

Address

Legacy Emanuel Hospital and Health Center & Children's Hospital

Portland, Oregon, 97227

Portland, Oregon

Status

Address

Doernbecher Children's Hospital at Oregon Health & Science University

Portland, Oregon, 97239-3098

Geisinger Medical Center, Danville, Pennsylvania

Status

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822-1320

Penn State Children's Hospital, Hershey, Pennsylvania

Status

Address

Penn State Children's Hospital

Hershey, Pennsylvania, 17033

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Status

Address

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104

St. Christopher's Hospital for Children, Philadelphia, Pennsylvania

Status

Address

St. Christopher's Hospital for Children

Philadelphia, Pennsylvania, 19134-1095

Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Status

Address

Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15213

Rhode Island Hospital, Providence, Rhode Island

Status

Address

Rhode Island Hospital

Providence, Rhode Island, 02903

Charleston, South Carolina

Status

Address

Hollings Cancer Center at Medical University of South Carolina

Charleston, South Carolina, 29425-0721

Columbia, South Carolina

Status

Address

Palmetto Health South Carolina Cancer Center

Columbia, South Carolina, 29203

Greenville, South Carolina

Status

Address

Children's Hospital of Greenville Hospital System

Greenville, South Carolina, 29605

Avera Cancer Institute, Sioux Falls, South Dakota

Status

Address

Avera Cancer Institute

Sioux Falls, South Dakota, 57105-1080

Sioux Falls, South Dakota

Status

Address

Sioux Valley Hospital and University of South Dakota Medical Center

Sioux Falls, South Dakota, 57117-5039

Johnson City, Tennessee

Status

Address

East Tennessee State University Cancer Center at Johnson City Medical Center

Johnson City, Tennessee, 37614-0622

East Tennessee Children's Hospital, Knoxville, Tennessee

Status

Address

East Tennessee Children's Hospital

Knoxville, Tennessee, 37901

St. Jude Children's Research Hospital, Memphis, Tennessee

Status

Address

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105

Vanderbilt Children's Hospital, Nashville, Tennessee

Status

Address

Vanderbilt Children's Hospital

Nashville, Tennessee, 37232-6310

Amarillo, Texas

Status

Address

Texas Tech University Health Sciences Center School of Medicine

Amarillo, Texas, 79106

Children's Hospital of Austin, Austin, Texas

Status

Address

Children's Hospital of Austin

Austin, Texas, 78701

Medical City Dallas Hospital, Dallas, Texas

Status

Address

Medical City Dallas Hospital

Dallas, Texas, 75230

Dallas, Texas

Status

Address

Simmons Cancer Center at University of Texas Southwestern Medical Center at Dallas

Dallas, Texas, 75390-9063

Fort Worth, Texas

Status

Address

Cook Children's Medical Center - Fort Worth

Fort Worth, Texas, 76104

University of Texas Medical Branch, Galveston, Texas

Status

Address

University of Texas Medical Branch

Galveston, Texas, 77555-0209

Houston, Texas

Status

Address

M.D. Anderson Cancer Center at University of Texas

Houston, Texas, 77030-4009

Baylor College of Medicine, Houston, Texas

Status

Address

Baylor College of Medicine

Houston, Texas, 77030

Lackland Air Force Base, Texas

Status

Address

San Antonio Military Pediatric Cancer and Blood Disorders Center

Lackland Air Force Base, Texas, 78236

Covenant Children's Hospital, Lubbock, Texas

Status

Address

Covenant Children's Hospital

Lubbock, Texas, 79410

San Antonio, Texas

Status

Address

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78207

MBCCOP - South Texas Pediatrics, San Antonio, Texas

Status

Address

MBCCOP - South Texas Pediatrics

San Antonio, Texas, 78229-3900

San Antonio, Texas

Status

Address

Methodist Cancer Center at Methodist Specialty and Transplant Hospital

San Antonio, Texas, 78229-3902

CCOP - Scott and White Hospital, Temple, Texas

Status

Address

CCOP - Scott and White Hospital

Temple, Texas, 76508

Temple, Texas

Status

Address

Center for Cancer Prevention and Care at Scott and White Clinic

Temple, Texas, 76508

Salt Lake City, Utah

Status

Address

Huntsman Cancer Institute at University of Utah

Salt Lake City, Utah, 84112

Burlington, Vermont

Status

Address

Vermont Cancer Center at University of Vermont

Burlington, Vermont, 05401-3498

University of Virginia Cancer Center, Charlottesville, Virginia

Status

Address

University of Virginia Cancer Center

Charlottesville, Virginia, 22908

INOVA Fairfax Hospital, Falls Church, Virginia

Status

Address

INOVA Fairfax Hospital

Falls Church, Virginia, 22042-3300

Norfolk, Virginia

Status

Address

Children's Hospital of the King's Daughters

Norfolk, Virginia, 23507

Naval Medical Center - Portsmouth, Portsmouth, Virginia

Status

Address

Naval Medical Center - Portsmouth

Portsmouth, Virginia, 23708-5100

Richmond, Virginia

Status

Address

Massey Cancer Center at Virginia Commonwealth University

Richmond, Virginia, 23298-0121

Roanoke, Virginia

Status

Address

Carilion Medical Center for Children at Roanoke Community Hospital

Roanoke, Virginia, 24029

Seattle, Washington

Status

Address

Children's Hospital and Regional Medical Center - Seattle

Seattle, Washington, 98105

Fred Hutchinson Cancer Research Center, Seattle, Washington

Status

Address

Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109-1024

Group Health Central Hospital, Seattle, Washington

Status

Address

Group Health Central Hospital

Seattle, Washington, 98112

Deaconess Medical Center, Spokane, Washington

Status

Address

Deaconess Medical Center

Spokane, Washington, 99210-0248

Tacoma, Washington

Status

Address

Mary Bridge Children's Hospital and Health Center - Tacoma

Tacoma, Washington, 98415-0299

Madigan Army Medical Center, Tacoma, Washington

Status

Address

Madigan Army Medical Center

Tacoma, Washington, 98431-0001

Charleston, West Virginia

Status

Address

West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division

Charleston, West Virginia, 25302

Cabell Huntington Hospital, Huntington, West Virginia

Status

Address

Cabell Huntington Hospital

Huntington, West Virginia, 25701

Morgantown, West Virginia

Status

Address

Mary Babb Randolph Cancer Center at West Virginia University Hospitals

Morgantown, West Virginia, 26506-9300

Bellin Memorial Hospital, Green Bay, Wisconsin

Status

Address

Bellin Memorial Hospital

Green Bay, Wisconsin, 54301

Green Bay, Wisconsin

Status

Address

CCOP - St. Vincent Hospital Cancer Center, Green Bay

Green Bay, Wisconsin, 54301

St. Vincent Hospital, Green Bay, Wisconsin

Status

Address

St. Vincent Hospital

Green Bay, Wisconsin, 54307-9070

La Crosse, Wisconsin

Status

Address

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Madison, Wisconsin

Status

Address

University of Wisconsin Comprehensive Cancer Center

Madison, Wisconsin, 53792-6164

Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin

Status

Address

Marshfield Clinic - Marshfield Center

Marshfield, Wisconsin, 54449-5772

Marshfield, Wisconsin

Status

Address

CCOP - Marshfield Clinic Research Foundation

Marshfield, Wisconsin, 54449

Midwest Children's Cancer Center, Milwaukee, Wisconsin

Status

Address

Midwest Children's Cancer Center

Milwaukee, Wisconsin, 53226

Long Beach, California

Status

Address

Jonathan Jaques Children's Cancer Center at Miller Children's Hospital

Long Beach, California, 90801-1428

Children's Hospital Los Angeles, Los Angeles, California

Status

Address

Children's Hospital Los Angeles

Los Angeles, California, 90027-0700

Los Angeles, California

Status

Address

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center

Los Angeles, California, 90048

Los Angeles, California

Status

Address

Jonsson Comprehensive Cancer Center at UCLA

Los Angeles, California, 90095-1781

Children's Hospital Central California, Madera, California

Status

Address

Children's Hospital Central California

Madera, California, 93638-8762

Oakland, California

Status

Address

Children's Hospital and Research Center at Oakland

Oakland, California, 94609-1809

Orange, California

Status

Address

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

Orange, California, 92868

Children's Hospital of Orange County, Orange, California

Status

Address

Children's Hospital of Orange County

Orange, California, 92868

Palo Alto, California

Status

Address

Lucile Packard Children's Hospital at Stanford University Medical Center

Palo Alto, California, 94304

Sutter Cancer Center, Sacramento, California

Status

Address

Sutter Cancer Center

Sacramento, California, 95816

Sacramento, California

Status

Address

University of California Davis Cancer Center

Sacramento, California, 95817

Sacramento, California

Status

Address

Kaiser Permanente Medical Center - Sacramento

Sacramento, California, 95825

San Diego, California

Status

Address

Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego

San Diego, California, 92120

San Diego, California

Status

Address

Children's Hospital and Health Center - San Diego

San Diego, California, 92123-4282

UCSF Comprehensive Cancer Center, San Francisco, California

Status

Address

UCSF Comprehensive Cancer Center

San Francisco, California, 94143

Santa Barbara Cottage Hospital, Santa Barbara, California

Status

Address

Santa Barbara Cottage Hospital

Santa Barbara, California, 93102

Santa Clara, California

Status

Address

Kaiser Permanente Medical Center - Santa Clara Kiely Campus

Santa Clara, California, 95051-5386

Travis Air Force Base, California

Status

Address

General Robert Huyser Cancer Center at David Grant Medical Center

Travis Air Force Base, California, 94535

Children's Hospital Cancer Center, Denver, Colorado

Status

Address

Children's Hospital Cancer Center

Denver, Colorado, 80218

Presbyterian - St. Luke's Medical Center, Denver, Colorado

Status

Address

Presbyterian - St. Luke's Medical Center

Denver, Colorado, 80218

Farmington, Connecticut

Status

Address

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center

Farmington, Connecticut, 06360-7106

Yale Comprehensive Cancer Center, New Haven, Connecticut

Status

Address

Yale Comprehensive Cancer Center

New Haven, Connecticut, 06520-8064

Alfred I. duPont Hospital for Children, Wilmington, Delaware

Status

Address

Alfred I. duPont Hospital for Children

Wilmington, Delaware, 19899

Washington, District of Columbia

Status

Address

Lombardi Cancer Center at Georgetown University Medical Center

Washington, District of Columbia, 20007

Children's National Medical Center, Washington, District of Columbia

Status

Address

Children's National Medical Center

Washington, District of Columbia, 20010-2970

Broward General Medical Center, Fort Lauderdale, Florida

Status

Address

Broward General Medical Center

Fort Lauderdale, Florida, 33316

Children's Hospital of Southwest Florida, Fort Myers, Florida

Status

Address

Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908

Gainesville, Florida

Status

Address

University of Florida Shands Cancer Center

Gainesville, Florida, 32610-0296

Hollywood, Florida

Status

Address

Joe DiMaggio Children's Hospital at Memorial

Hollywood, Florida, 33021

Nemours Children's Clinic, Jacksonville, Florida

Status

Address

Nemours Children's Clinic

Jacksonville, Florida, 32207

Jackson Memorial Hospital, Miami, Florida

Status

Address

Jackson Memorial Hospital

Miami, Florida, 33136

Miami Children's Hospital, Miami, Florida

Status

Address

Miami Children's Hospital

Miami, Florida, 33155

Miami, Florida

Status

Address

Baptist-South Miami Regional Cancer Program

Miami, Florida, 33176-2197

Florida Hospital Cancer Institute, Orlando, Florida

Status

Address

Florida Hospital Cancer Institute

Orlando, Florida, 32804

Nemours Children's Clinic-Orlando, Orlando, Florida

Status

Address

Nemours Children's Clinic-Orlando

Orlando, Florida, 32806

Sacred Heart Children's Hospital, Pensacola, Florida

Status

Address

Sacred Heart Children's Hospital

Pensacola, Florida, 32504

All Children's Hospital, St. Petersburg, Florida

Status

Address

All Children's Hospital

St. Petersburg, Florida, 33701

Tampa, Florida

Status

Address

St. Joseph's Children's Hospital of Tampa

Tampa, Florida, 33677-4227

West Palm Beach, Florida

Status

Address

Kaplan Cancer Center at St. Mary's Medical Center

West Palm Beach, Florida, 33407

Atlanta, Georgia

Status

Address

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus

Atlanta, Georgia, 30342

Augusta, Georgia

Status

Address

MBCCOP-Medical College of Georgia Cancer Center

Augusta, Georgia, 30912-4000

Medical Center of Central Georgia, Macon, Georgia

Status

Address

Medical Center of Central Georgia

Macon, Georgia, 31201

Savannah, Georgia

Status

Address

Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

Savannah, Georgia, 31405

Cancer Research Center of Hawaii, Honolulu, Hawaii

Status

Address

Cancer Research Center of Hawaii

Honolulu, Hawaii, 96813

Tripler Army Medical Center, Honolulu, Hawaii

Status

Address

Tripler Army Medical Center

Honolulu, Hawaii, 96859-5000

Boise, Idaho

Status

Address

St. Luke's Mountain States Tumor Institute - Boise

Boise, Idaho, 83712

Chicago, Illinois

Status

Address

University of Chicago Cancer Research Center

Chicago, Illinois, 60601

Rush University Medical Center, Chicago, Illinois

Status

Address

Rush University Medical Center

Chicago, Illinois, 60612

University of Illinois Medical Center, Chicago, Illinois

Status

Address

University of Illinois Medical Center

Chicago, Illinois, 60612

Children's Memorial Hospital - Chicago, Chicago, Illinois

Status

Address

Children's Memorial Hospital - Chicago

Chicago, Illinois, 60614

Advocate Hope Children's Hospital, Oak Lawn, Illinois

Status

Address

Advocate Hope Children's Hospital

Oak Lawn, Illinois, 60453

Lutheran General Cancer Care Center, Park Ridge, Illinois

Status

Address

Lutheran General Cancer Care Center

Park Ridge, Illinois, 60068-1174

Saint Jude Midwest Affiliate, Peoria, Illinois

Status

Address

Saint Jude Midwest Affiliate

Peoria, Illinois, 61637

Springfield, Illinois

Status

Address

Southern Illinois University School of Medicine

Springfield, Illinois, 62794-9658

Indianapolis, Indiana

Status

Address

Riley Children Cancer Center at Riley Hospital for Children

Indianapolis, Indiana, 46202-5225

Indianapolis, Indiana

Status

Address

St. Vincent Hospitals and Health Care Centers

Indianapolis, Indiana, 46260

Blank Children's Hospital, Des Moines, Iowa

Status

Address

Blank Children's Hospital

Des Moines, Iowa, 50309

Iowa City, Iowa

Status

Address

Holden Comprehensive Cancer Center at University of Iowa

Iowa City, Iowa, 52242-1009

Wesley Medical Center, Wichita, Kansas

Status

Address

Wesley Medical Center

Wichita, Kansas, 67214

Lexington, Kentucky

Status

Address

Markey Cancer Center at University of Kentucky Chandler Medical Center

Lexington, Kentucky, 40536-0284

Kosair Children's Hospital, Louisville, Kentucky

Status

Address

Kosair Children's Hospital

Louisville, Kentucky, 40202-3830

MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana

Status

Address

MBCCOP - LSU Health Sciences Center

New Orleans, Louisiana, 70112

New Orleans, Louisiana

Status

Address

Tulane Cancer Center at Tulane University Hospital and Clinic

New Orleans, Louisiana, 70112

Children's Hospital of New Orleans, New Orleans, Louisiana

Status

Address

Children's Hospital of New Orleans

New Orleans, Louisiana, 70118

New Orleans, Louisiana

Status

Address

Ochsner Cancer Institute at Ochsner Clinic Foundation

New Orleans, Louisiana, 70121

Bangor, Maine

Status

Address

Pediatric Specialty Clinic at Eastern Maine Medical Center

Bangor, Maine, 04401

Maine Children's Cancer Program, Scarborough, Maine

Status

Address

Maine Children's Cancer Program

Scarborough, Maine, 04074-9308

Baltimore, Maryland

Status

Address

Greenebaum Cancer Center at University of Maryland Medical Center

Baltimore, Maryland, 21201-1595

Baltimore, Maryland

Status

Address

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

Baltimore, Maryland, 21215

Baltimore, Maryland

Status

Address

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, 21231-7223

Walter Reed Army Medical Center, Silver Spring, Maryland

Status

Address

Walter Reed Army Medical Center

Silver Spring, Maryland, 20910

Floating Hospital for Children, Boston, Massachusetts

Status

Address

Floating Hospital for Children

Boston, Massachusetts, 02111

Boston, Massachusetts

Status

Address

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute

Boston, Massachusetts, 02115

Springfield, Massachusetts

Status

Address

Baystate Regional Cancer Program at D'Amour Center for Cancer Care

Springfield, Massachusetts, 01107

Worcester, Massachusetts

Status

Address

UMASS Memorial Cancer Center - University Campus

Worcester, Massachusetts, 01655

Ann Arbor, Michigan

Status

Address

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109-0914

Children's Hospital of Michigan, Detroit, Michigan

Status

Address

Children's Hospital of Michigan

Detroit, Michigan, 48201

Birmingham, Alabama

Status

Address

Comprehensive Cancer Center at University of Alabama at Birmingham

Birmingham, Alabama, 35233

Mobile, Alabama

Status

Address

University of South Alabama Cancer Research Institute

Mobile, Alabama, 36604

Phoenix Children's Hospital, Phoenix, Arizona

Status

Address

Phoenix Children's Hospital

Phoenix, Arizona, 85016

Tucson, Arizona

Status

Address

Arizona Cancer Center at University of Arizona Health Sciences Center

Tucson, Arizona, 85724

Little Rock, Arkansas

Status

Address

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

Downey, California

Status

Address

Southern California Permanente Medical Group

Downey, California, 90242

City of Hope Comprehensive Cancer Center, Duarte, California

Status

Address

City of Hope Comprehensive Cancer Center

Duarte, California, 91010-3000

La Jolla, California

Status

Address

Rebecca and John Moores UCSD Cancer Center

La Jolla, California, 92093-0658

Loma Linda, California

Status

Address

Loma Linda University Cancer Institute at Loma Linda University Medical Center

Loma Linda, California, 92354

International Sites

Sydney Children's Hospital, Randwick, New South Wales, Australia

Status

Address

Sydney Children's Hospital

Randwick, New South Wales, 2031

Children's Hospital at Westmead, Westmead, New South Wales, Australia

Status

Address

Children's Hospital at Westmead

Westmead, New South Wales, 2145

Royal Children's Hospital, Brisbane, Queensland, Australia

Status

Address

Royal Children's Hospital

Brisbane, Queensland, 4029

Women's and Children's Hospital, North Adelaide, South Australia, Australia

Status

Address

Women's and Children's Hospital

North Adelaide, South Australia, 5006

Royal Children's Hospital, Parkville, Victoria, Australia

Status

Address

Royal Children's Hospital

Parkville, Victoria, 3052

Princess Margaret Hospital for Children, Perth, Western Australia, Australia

Status

Address

Princess Margaret Hospital for Children

Perth, Western Australia, 6001

Alberta Children's Hospital, Calgary, Alberta, Canada

Status

Address

Alberta Children's Hospital

Calgary, Alberta, T2T 5C7

Edmonton, Alberta, Canada

Status

Address

Cross Cancer Institute at University of Alberta

Edmonton, Alberta, T6G 1Z2

British Columbia Children's Hospital, Vancouver, British Columbia, Canada

Status

Address

British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Status

Address

CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9

St. John's, Newfoundland and Labrador, Canada

Status

Address

Janeway Children's Health and Rehabilitation Centre

St. John's, Newfoundland and Labrador, A1B 3V6

IWK Health Centre, Halifax, Nova Scotia, Canada

Status

Address

IWK Health Centre

Halifax, Nova Scotia, B3J 3G9

Hamilton, Ontario, Canada

Status

Address

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Ontario, L8S 4J9

Children's Hospital of Western Ontario, London, Ontario, Canada

Status

Address

Children's Hospital of Western Ontario

London, Ontario, N6C 2V5

Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada

Status

Address

Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 8L1

Hospital for Sick Children, Toronto, Ontario, Canada

Status

Address

Hospital for Sick Children

Toronto, Ontario, M5G 1X8

Montreal, Quebec, Canada

Status

Address

Montreal Children's Hospital at McGill University Health Center

Montreal, Quebec, H3G 1A4

Hopital Sainte Justine, Montreal, Quebec, Canada

Status

Address

Hopital Sainte Justine

Montreal, Quebec, H3T 1C5

Sainte Foy, Quebec, Canada

Status

Address

Centre de Recherche du Centre Hospitalier de l'Universite Laval

Sainte Foy, Quebec, GIV 4G2

Regina, Saskatchewan, Canada

Status

Address

Allan Blair Cancer Centre at Pasqua Hospital

Regina, Saskatchewan, S4T 7T1

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Status

Address

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4

University Medical Center Groningen, Groningen, Netherlands

Status

Address

University Medical Center Groningen

Groningen, , 9700 RB

Starship Children's Health, Auckland, New Zealand

Status

Address

Starship Children's Health

Auckland, ,

San Juan, Puerto Rico

Status

Address

Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus

San Juan, , 00936-5067

San Jorge Children's Hospital, Santurce, Puerto Rico

Status

Address

San Jorge Children's Hospital

Santurce, , 00912

Swiss Pediatric Oncology Group Bern, Bern, Switzerland

Status

Address

Swiss Pediatric Oncology Group Bern

Bern, , CH 3010

Swiss Pediatric Oncology Group Geneva, Geneva, Switzerland

Status

Address

Swiss Pediatric Oncology Group Geneva

Geneva, , CH 1211

Swiss Pediatric Oncology Group Lausanne, Lausanne, Switzerland

Status

Address

Swiss Pediatric Oncology Group Lausanne

Lausanne, , CH 1011