Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma
Study Purpose
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known which schedule of temozolomide when given together with radiation therapy is more effective in treating glioblastoma or gliosarcoma. PURPOSE: This randomized phase III trial is studying two different schedules of temozolomide to compare how well they work when given together with radiation therapy in treating patients with newly diagnosed glioblastoma or gliosarcoma.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion criteria:
1. Histopathologically proven diagnosis of glioblastoma. Since gliosarcoma is a variant of glioblastoma, gliosarcoma is also an eligible diagnosis. 2. Patients must have at least 1 block of tissue available for analysis of MGMT status; fresh frozen tumor tissue acquisition is encouraged. 3. Diagnosis must be established by open biopsy or tumor resection. Patients who have only had a stereotactic biopsy are not eligible. 4. The tumor must have a supratentorial component. 5. Patients must have recovered from the effects of surgery, postoperative infection, and other complications before study registration. 6. A diagnostic contrast-enhanced magnetic resonance imaging (MRI) or computerized tomography (CT) scan (if MRI is not available) of the brain must be performed preoperatively and postoperatively. The postoperative scan must be done within 28 days of registration and prior to the initiation of radiotherapy. Preoperative and postoperative scans must be the same type. If CT scans were performed perioperatively, a CT and an MRI should be performed before randomization. 6.1. Patients unable to undergo MRI imaging because of non-compatible devices can be enrolled, provided pre- and post-operative contrast-enhanced CT scans are obtained and are of sufficient quality. 7. Therapy must begin ≤ 5 weeks after the most recent brain tumor surgery. 8. History/physical examination within 14 days prior to study registration. 9. Neurologic examination within 14 days prior to study registration. 10. Documentation of steroid doses within 14 days prior to study registration and stable or decreasing steroid dose within 5 days prior to registration. 11. Karnofsky performance status of ≥ 60. 12. Age ≥ 18 years. 13. Complete blood count (CBC)/differential obtained within 14 days prior to study registration, with adequate bone marrow function as defined below: 13.1 Absolute neutrophil count (ANC) ≥ 1500 cells/mm3. 13.2 Platelets ≥ 100,000 cells/mm3. 13.3 Hemoglobin ≥ 10 g/dl. (Note: The use of transfusion or other intervention to achieve Hgb ≥ 10 g/dl is acceptable.) 14. Adequate renal function, as defined below: 14.1 Blood urea nitrogen (BUN) ≤ 25 mg/dl within 14 days prior to study registration 14.2 Creatinine ≤ 1.7 mg/dl within 14 days prior to study registration. 15. Adequate hepatic function, as defined below: 15.1 Bilirubin ≤ 2.0 mg/dl within 14 days prior to study registration 15.2 Alanine aminotransferase (ALT) ≤ 3 x normal range within 14 days prior to study registration 15.3 Aspartate aminotransferase (AST) ≤ 3 x normal range within 14 days prior to study registration. 16. Patients must sign a study-specific informed consent prior to study registration. If the patient's mental status precludes his/her giving informed consent, written informed consent may be given by the responsible family member. 17. For females of child-bearing potential, negative serum pregnancy test within 72 hours prior to starting temozolomide. 18. Women of childbearing potential and male participants must practice adequate.Exclusion criteria:
1. Prior invasive malignancy (except for non-melanomatous skin cancer) unless disease free for ≥ 3 years. (For example, carcinoma in situ of the breast, oral cavity, and cervix are all permissible). 2. Recurrent or multifocal malignant gliomas. 3. Metastases detected below the tentorium or beyond the cranial vault. 4. Prior chemotherapy or radiosensitizers for cancers of the head and neck region; note that prior chemotherapy for a different cancer is allowable. Prior use of Gliadel wafers or any other intratumoral or intracavitary treatment are not permitted. See Section 1. 5. Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in overlap of radiation fields. 6. Severe, active co-morbidity, defined as follows:- - 6.1.
- - 6.2.
- - 6.3.
- - 6.4.
- - 6.5.
- - 6.6.
- - 6.7.
- - 6.8.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00304031 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Radiation Therapy Oncology Group |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Mark R. Gilbert, MDMinesh P. Mehta, MDRoger Stupp, MD |
| Principal Investigator Affiliation | M.D. Anderson Cancer CenterUniversity of Wisconsin, MadisonCentre Hospitalier Universitaire Vaudois |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Completed |
| Countries | Canada, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Brain and Central Nervous System Tumors |
OBJECTIVES: Primary.
- - Determine if dose-intensifying (increasing the "dose-density") the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by overall survival of patients with newly diagnosed glioblastoma or gliosarcoma.
- - Determine if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by progression-free survival.
- - Determine in patients with unmethylated MGMT (O-6-methylguanine-DNA methyltransferase) if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy (overall and progression-free survival) compared with patients receiving conventional temozolomide dosing.
- - Determine in patients with methylated MGMT if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy (overall and progression-free survival) compared with patients receiving conventional temozolomide dosing.
- - Determine if there is an association between tumor MGMT gene methylation status and treatment response.
- - Compare and record the toxicities of the conventional and dose-intense chemotherapy regimens.
- - Evaluate whether 6-month progression-free survival is associated with overall survival.
Arms
Active Comparator: Conventional adjuvant TMZ
Concurrent radiation therapy with concurrent temozolomide (75 mg/m2) up to 49 doses. Starting four weeks after completion of RT, 100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle.
Experimental: Dose-dense adjuvant TMZ
Concurrent radiation therapy (RT) with concurrent temozolomide (75 mg/m2) up to 49 doses. Starting four weeks after completion of RT, 75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle.
Other: No adjuvant TMZ (not randomized )
Concurrent radiation therapy (RT) with concurrent temozolomide (75 mg/m2) up to 49 doses. Not randomized to either adjuvant TMZ arm.
Interventions
Drug: - Concurrent temozolomide
Daily oral temozolomide (75 mg/m2) up to 49 doses.
Radiation: - Concurrent radiation therapy
60 Gy in 2 Gy fractions
Drug: - 100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle
Oral temozolomide on days 1-5 of a 28-day cycle. Dose starts at 150mg/m2 for first cycle, increases to 200mg/m2 for subsequent cycles if no unacceptable toxicity. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients with responding disease may receive up to 6 more courses of temozolomide.
Drug: - 75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle
Oral temozolomide on days 1-21 of a 28-day cycle. Dose starts at 75mg/m2 for first cycle, increases to 100mg/m2 for subsequent cycles if no unacceptable toxicity. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients with responding disease may receive up to 6 more courses of temozolomide.
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701
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Arizona Oncology Services Foundation
Phoenix, Arizona, 85013
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Mayo Clinic Scottsdale
Scottsdale, Arizona, 85259-5499
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Arizona Oncology - Tucson
Tucson, Arizona, 85704
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Address
Auburn Radiation Oncology
Auburn, California, 95603
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Address
Providence Saint Joseph Medical Center - Burbank
Burbank, California, 91505
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Address
Radiation Oncology Centers - Cameron Park
Cameron Park, California, 95682
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Address
Mercy Cancer Center at Mercy San Juan Medical Center
Carmichael, California, 95608
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Address
City of Hope Comprehensive Cancer Center
Duarte, California, 91010-3000
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Address
Kaiser Permanente Medical Center - Los Angeles
Los Angeles, California, 90027
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Address
Radiation Oncology Center - Roseville
Roseville, California, 95661
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Radiological Associates of Sacramento Medical Group, Incorporated
Sacramento, California, 95815
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Address
Mercy General Hospital
Sacramento, California, 95819
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UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94115
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Solano Radiation Oncology Center
Vacaville, California, 95687
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Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, 80933
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Poudre Valley Radiation Oncology
Fort Collins, Colorado, 80528
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Yale Cancer Center
New Haven, Connecticut, 06520-8028
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Tunnell Cancer Center at Beebe Medical Center
Lewes, Delaware, 19958
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Address
CCOP - Christiana Care Health Services
Newark, Delaware, 19713
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Address
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
Boca Raton, Florida, 33486
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University of Florida Shands Cancer Center
Gainesville, Florida, 32610-0232
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Address
Integrated Community Oncology Network
Jacksonville Beach, Florida, 32250
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Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, 32207
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Address
Integrated Community Oncology Network at Southside Cancer Center
Jacksonville, Florida, 32207
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Mayo Clinic - Jacksonville
Jacksonville, Florida, 32224
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Address
Baptist Medical Center South
Jacksonville, Florida, 32258
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Address
Baptist-South Miami Regional Cancer Program
Miami, Florida, 33176
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Address
Integrated Community Oncology Network - Orange Park
Orange Park, Florida, 32073
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Florida Cancer Center - Palatka
Palatka, Florida, 32177
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Flagler Cancer Center
Saint Augustine, Florida, 32086
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Address
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
Tampa, Florida, 33612-9497
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Piedmont Hospital
Atlanta, Georgia, 30309
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Address
John B. Amos Cancer Center
Columbus, Georgia, 31904
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Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706
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Northwest Community Hospital
Arlington Heights, Illinois, 60005
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Rush-Copley Cancer Care Center
Aurora, Illinois, 60504
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St. Joseph Medical Center
Bloomington, Illinois, 61701
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Graham Hospital
Canton, Illinois, 61520
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Memorial Hospital
Carthage, Illinois, 62321
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Address
John H. Stroger, Jr. Hospital of Cook County
Chicago, Illinois, 60612-3785
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University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470
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Eureka Community Hospital
Eureka, Illinois, 61530
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Galesburg Clinic, PC
Galesburg, Illinois, 61401
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Galesburg Cottage Hospital
Galesburg, Illinois, 61401
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InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, 61401
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Mason District Hospital
Havana, Illinois, 62644
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Hopedale Medical Complex
Hopedale, Illinois, 61747
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Address
Joliet Oncology-Hematology Associates, Limited - West
Joliet, Illinois, 60435
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McDonough District Hospital
Macomb, Illinois, 61455
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Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153
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BroMenn Regional Medical Center
Normal, Illinois, 61761
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Community Cancer Center
Normal, Illinois, 61761
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Address
Community Hospital of Ottawa
Ottawa, Illinois, 61350
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Address
Oncology Hematology Associates of Central Illinois, PC - Ottawa
Ottawa, Illinois, 61350
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Address
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, 61554
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Address
Proctor Hospital
Peoria, Illinois, 61614
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Address
OSF St. Francis Medical Center
Peoria, Illinois, 61615-7827
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Address
CCOP - Illinois Oncology Research Association
Peoria, Illinois, 61615
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Address
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria, Illinois, 61615
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Address
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
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Address
Illinois Valley Community Hospital
Peru, Illinois, 61354
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Address
Perry Memorial Hospital
Princeton, Illinois, 61356
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Address
St. Margaret's Hospital
Spring Valley, Illinois, 61362
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Address
Valley Cancer Center
Spring Valley, Illinois, 61362
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Address
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, 61801
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Address
CCOP - Carle Cancer Center
Urbana, Illinois, 61801
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Address
Elkhart General Hospital
Elkhart, Indiana, 46515
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Address
Radiation Oncology Associates Southwest
Fort Wayne, Indiana, 46804
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Address
Parkview Regional Cancer Center at Parkview Health
Fort Wayne, Indiana, 46805
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Address
Central Indiana Cancer Centers - East
Indianapolis, Indiana, 46219
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Address
Howard Community Hospital
Kokomo, Indiana, 46904
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Address
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, 46350
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Address
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360
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Address
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, 46601
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Address
Memorial Hospital of South Bend
South Bend, Indiana, 46601
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Saint Joseph Regional Medical Center
South Bend, Indiana, 46617
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South Bend Clinic
South Bend, Indiana, 46617
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Address
McFarland Clinic, PC
Ames, Iowa, 50010
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Address
Mercy Capitol Hospital
Des Moines, Iowa, 50307
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Address
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309
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Address
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, 50309
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Address
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, 50309
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Address
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, 50314
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Address
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
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John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, 50316
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Address
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City, Iowa, 50401
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Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, 66720
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Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, 67801
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Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, 67042
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Address
Cancer Center of Kansas-Independence
Independence, Kansas, 67301
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Address
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, 67068
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Address
Southwest Medical Center
Liberal, Kansas, 67901
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Address
Cancer Center of Kansas, PA - Newton
Newton, Kansas, 67114
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Menorah Medical Center
Overland Park, Kansas, 66209
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Address
Kansas City Cancer Centers - Southwest
Overland Park, Kansas, 66210
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Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, 67357
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Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, 67124
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Cancer Center of Kansas, PA - Salina
Salina, Kansas, 67042
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Shawnee Mission Medical Center
Shawnee Mission, Kansas, 66204
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Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, 67152
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Associates in Womens Health, PA - North Review
Wichita, Kansas, 67208
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Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, 67208
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Address
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, 67214
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Address
CCOP - Wichita
Wichita, Kansas, 67214
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Address
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214
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Wesley Medical Center
Wichita, Kansas, 67214
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Address
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, 67156
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DeCesaris Cancer Institute at Anne Arundel Medical Center
Annapolis, Maryland, 21401
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St. Agnes Hospital Cancer Center
Baltimore, Maryland, 21229
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Address
Union Hospital Cancer Program at Union Hospital
Elkton, Maryland, 21921
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Address
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, 49221
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Address
Saint Joseph Mercy Cancer Center
Ann Arbor, Michigan, 48106-0995
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Address
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106
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Address
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123-2500
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Address
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202
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Address
Green Bay Oncology, Limited - Escanaba
Escanaba, Michigan, 49431
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Address
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
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Address
Hurley Medical Center
Flint, Michigan, 48503
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Address
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, 48236
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Address
Dickinson County Healthcare System
Iron Mountain, Michigan, 49801
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Address
Foote Memorial Hospital
Jackson, Michigan, 49201
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Address
Borgess Medical Center
Kalamazoo, Michigan, 49001
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Address
West Michigan Cancer Center
Kalamazoo, Michigan, 49007-3731
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Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
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Address
Haematology-Oncology Associates of Ohio and Michigan, PC
Lambertville, Michigan, 48144
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Address
Sparrow Regional Cancer Center
Lansing, Michigan, 48912-1811
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Address
St. Mary Mercy Hospital
Livonia, Michigan, 48154
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Address
Community Cancer Center of Monroe
Monroe, Michigan, 48162
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Address
Mercy Memorial Hospital - Monroe
Monroe, Michigan, 48162
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Address
St. Joseph Mercy Oakland
Pontiac, Michigan, 48341-2985
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Address
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, 48060
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Address
William Beaumont Hospital - Royal Oak Campus
Royal Oak, Michigan, 48073
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Address
Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw, Michigan, 48601
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Address
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph, Michigan, 49085
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Address
Providence Cancer Institute at Providence Hospital - Southfield Campus
Southfield, Michigan, 48075
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St. John Macomb Hospital
Warren, Michigan, 48093
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Alexandria, Minnesota, 56308
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Address
MeritCare Bemidji
Bemidji, Minnesota, 56601
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Address
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
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Address
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, 55433
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Address
Fairview Southdale Hospital
Edina, Minnesota, 55435
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Address
Fergus Falls, Minnesota, 56537
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Address
Mercy and Unity Cancer Center at Unity Hospital
Fridley, Minnesota, 55432
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Address
Minnesota Oncology Hematology, PA - Maplewood
Maplewood, Minnesota, 55109
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Address
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis, Minnesota, 55407
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Address
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale, Minnesota, 55422-2900
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Address
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905
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Address
CentraCare Clinic - River Campus
Saint Cloud, Minnesota, 56303
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Address
Coborn Cancer Center
Saint Cloud, Minnesota, 56303
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Address
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416
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Address
Park Nicollet Cancer Center
Saint Louis Park, Minnesota, 55416
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Address
United Hospital
Saint Paul, Minnesota, 55102
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Address
Ridgeview Medical Center
Waconia, Minnesota, 55387
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Address
Minnesota Oncology Hematology, PA - Woodbury
Woodbury, Minnesota, 55125
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Address
Independence Regional Health Center
Independence, Missouri, 64050
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Address
St. John's Regional Medical Center
Joplin, Missouri, 64804
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Address
Truman Medical Center - Hospital Hill
Kansas City, Missouri, 64108
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Address
Saint Luke's Cancer Institute at Saint Luke's Hospital
Kansas City, Missouri, 64111
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Address
St. Joseph Medical Center
Kansas City, Missouri, 64114
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Address
North Kansas City Hospital
Kansas City, Missouri, 64116
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Address
Parvin Radiation Oncology
Kansas City, Missouri, 64116
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Address
CCOP - Kansas City
Kansas City, Missouri, 64131
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Address
Kansas City Cancer Centers - South
Kansas City, Missouri, 64131
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Address
Research Medical Center
Kansas City, Missouri, 64132
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Address
Liberty Hospital
Liberty, Missouri, 64068
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Address
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
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Address
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65802
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Address
St. John's Regional Health Center
Springfield, Missouri, 65804
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Address
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, 65807
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Address
CCOP - Montana Cancer Consortium
Billings, Montana, 59101
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Address
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, 59101
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Address
Northern Rockies Radiation Oncology Center
Billings, Montana, 59101
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Address
St. Vincent Healthcare Cancer Care Services
Billings, Montana, 59101
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Address
Billings Clinic - Downtown
Billings, Montana, 59107-7000
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Address
St. James Healthcare Cancer Care
Butte, Montana, 59701
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Address
Great Falls Clinic - Main Facility
Great Falls, Montana, 59405
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Address
Great Falls, Montana, 59405
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Address
Northern Montana Hospital
Havre, Montana, 59501
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Address
Glacier Oncology, PLLC
Kalispell, Montana, 59901
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Address
Kalispell Medical Oncology at KRMC
Kalispell, Montana, 59901
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Address
Kalispell Regional Medical Center
Kalispell, Montana, 59901
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Address
Community Medical Center
Missoula, Montana, 59801
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Address
Guardian Oncology and Center for Wellness
Missoula, Montana, 59804
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Address
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, 59807-7877
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Address
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, 59807
Status
Address
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney, Nebraska, 68848-1990
Status
Address
Cancer Resource Center - Lincoln
Lincoln, Nebraska, 68510
Status
Address
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106
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Address
Methodist Estabrook Cancer Center
Omaha, Nebraska, 68114
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Address
Immanuel Medical Center
Omaha, Nebraska, 68122
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Address
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Status
Address
Creighton University Medical Center
Omaha, Nebraska, 68131-2197
Status
Address
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102
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Address
CCOP - Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106
Status
Address
Dartmouth - Hitchcock Concord
Concord, New Hampshire, 03301
Status
Address
Kingsbury Center for Cancer Care at Cheshire Medical Center
Keene, New Hampshire, 03431
Status
Address
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756-0002
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Address
St. Barnabas Medical Center Cancer Center
Livingston, New Jersey, 07039
Status
Address
Frederick R. and Betty M. Smith Cancer Treatment Center
Sparta, New Jersey, 07871
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Address
Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees, New Jersey, 08043
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Address
New York Methodist Hospital
Brooklyn, New York, 11215
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Address
Monter Cancer Center of the North Shore-LIJ Health System
Lake Success, New York, 11042
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Address
CCOP - North Shore University Hospital
Manhasset, New York, 11030
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Address
Don Monti Comprehensive Cancer Center at North Shore University Hospital
Manhasset, New York, 11030
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Address
Long Island Jewish Medical Center
New Hyde Park, New York, 11040
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Address
Memorial Sloan-Kettering Cancer Center
New York, New York, 10065
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Address
Hudson Valley Oncology Associates
Poughkeepsie, New York, 12601
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Address
Lipson Cancer and Blood Center at Rochester General Hospital
Rochester, New York, 14621
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Address
Mission Hospitals - Memorial Campus
Asheville, North Carolina, 28801
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Address
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534
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Address
Wayne Radiation Oncology
Goldsboro, North Carolina, 27534
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Address
Rutherford Hospital
Rutherfordton, North Carolina, 28139
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Address
Wilmed Radiation Oncology Services
Wilson, North Carolina, 27893
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Address
CCOP - MeritCare Hospital
Fargo, North Dakota, 58122
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Address
MeritCare Broadway
Fargo, North Dakota, 58122
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Address
McDowell Cancer Center at Akron General Medical Center
Akron, Ohio, 44307
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Address
Summa Center for Cancer Care at Akron City Hospital
Akron, Ohio, 44309-2090
Status
Address
Mary Rutan Hospital
Bellefontaine, Ohio, 43311
Status
Address
Wood County Oncology Center
Bowling Green, Ohio, 43402
Status
Address
Aultman Cancer Center at Aultman Hospital
Canton, Ohio, 44710-1799
Status
Address
Adena Regional Medical Center
Chillicothe, Ohio, 45601
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Address
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland, Ohio, 44111
Status
Address
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195
Status
Address
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, 43214-3998
Status
Address
CCOP - Columbus
Columbus, Ohio, 43215
Status
Address
Grant Medical Center Cancer Care
Columbus, Ohio, 43215
Status
Address
Mount Carmel Health - West Hospital
Columbus, Ohio, 43222
Status
Address
Doctors Hospital at Ohio Health
Columbus, Ohio, 43228
Status
Address
Grady Memorial Hospital
Delaware, Ohio, 43015
Status
Address
Cleveland Clinic Cancer Center
Independence, Ohio, 44131
Status
Address
Fairfield Medical Center
Lancaster, Ohio, 43130
Status
Address
Lima Memorial Hospital
Lima, Ohio, 45804
Status
Address
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, 45750
Status
Address
Northwest Ohio Oncology Center
Maumee, Ohio, 43537
Status
Address
St. Luke's Hospital
Maumee, Ohio, 43537
Status
Address
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, 43055
Status
Address
St. Charles Mercy Hospital
Oregon, Ohio, 43616
Status
Address
Toledo Clinic - Oregon
Oregon, Ohio, 43616
Status
Address
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
Salem, Ohio, 44460
Status
Address
North Coast Cancer Care, Incorporated
Sandusky, Ohio, 44870
Status
Address
Mercy Medical Center
Springfield, Ohio, 45504
Status
Address
Community Hospital of Springfield and Clark County
Springfield, Ohio, 45505
Status
Address
Flower Hospital Cancer Center
Sylvania, Ohio, 43560
Status
Address
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883
Status
Address
Toledo Hospital
Toledo, Ohio, 43606
Status
Address
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608
Status
Address
Medical University of Ohio Cancer Center
Toledo, Ohio, 43614
Status
Address
CCOP - Toledo Community Hospital
Toledo, Ohio, 43617
Status
Address
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, 43623
Status
Address
Fulton County Health Center
Wauseon, Ohio, 43567
Status
Address
Mount Carmel St. Ann's Cancer Center
Westerville, Ohio, 43081
Status
Address
Cancer Treatment Center
Wooster, Ohio, 44691
Status
Address
Genesis - Good Samaritan Hospital
Zanesville, Ohio, 43701
Status
Address
Oklahoma University Cancer Institute
Oklahoma City, Oklahoma, 73104
Status
Address
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, 74136
Status
Address
Willamette Valley Cancer Center - Eugene
Eugene, Oregon, 97401
Status
Address
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030
Status
Address
Providence Milwaukie Hospital
Milwaukie, Oregon, 97222
Status
Address
Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Portland, Oregon, 97210
Status
Address
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, 97213-2967
Status
Address
Adventist Medical Center
Portland, Oregon, 97216
Status
Address
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225
Status
Address
Providence St. Vincent Medical Center
Portland, Oregon, 97225
Status
Address
Legacy Emanuel Hospital and Health Center and Children's Hospital
Portland, Oregon, 97227
Status
Address
Salem Hospital Regional Cancer Care Services
Salem, Oregon, 97309-5014
Status
Address
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062
Status
Address
Rosenfeld Cancer Center at Abington Memorial Hospital
Abington, Pennsylvania, 19001
Status
Address
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, 18105
Status
Address
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010
Status
Address
Geisinger Cancer Institute at Geisinger Health
Danville, Pennsylvania, 17822-0001
Status
Address
Northeast Radiation Oncology Center
Dunmore, Pennsylvania, 18512
Status
Address
Dale and Frances Hughes Cancer Center at Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
Status
Address
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
Status
Address
Riddle Memorial Hospital Cancer Center
Media, Pennsylvania, 19063
Status
Address
Upper Delaware Valley Cancer Center
Milford, Pennsylvania, 18337
Status
Address
Intercommunity Cancer Center
Monroeville, Pennsylvania, 15146
Status
Address
Alle-Kiski Medical Center
Natrona Heights, Pennsylvania, 15065
Status
Address
Cancer Center of Paoli Memorial Hospital
Paoli, Pennsylvania, 19301-1792
Status
Address
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, 19107-5541
Status
Address
Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, 19111-2497
Status
Address
Frankford Hospital Cancer Center - Torresdale Campus
Philadelphia, Pennsylvania, 19114
Status
Address
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Status
Address
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
Reading, Pennsylvania, 19612-6052
Status
Address
Somerset Oncology Center
Somerset, Pennsylvania, 15501
Status
Address
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711
Status
Address
CCOP - Main Line Health
Wynnewood, Pennsylvania, 19096
Status
Address
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, 19096
Status
Address
AnMed Cancer Center
Anderson, South Carolina, 29621
Status
Address
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425
Status
Address
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303
Status
Address
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg, South Carolina, 29303
Status
Address
Rapid City Regional Hospital
Rapid City, South Dakota, 57701
Status
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
Status
Address
Medical X-Ray Center, PC
Sioux Falls, South Dakota, 57105
Status
Address
Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls, South Dakota, 57117-5039
Status
Address
Thompson Cancer Survival Center West
Knoxville, Tennessee, 37392
Status
Address
Thompson Cancer Survival Center
Knoxville, Tennessee, 37916
Status
Address
Thompson Cancer Survival Center at Methodist
Oak Ridge, Tennessee, 37830
Status
Address
Medical City Dallas Hospital
Dallas, Texas, 75230
Status
Address
Texas Oncology, PA at Texas Cancer Center Dallas Southwest
Dallas, Texas, 75237
Status
Address
Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
Fort Worth, Texas, 76104
Status
Address
M. D. Anderson Cancer Center at University of Texas
Houston, Texas, 77030-4009
Status
Address
Joe Arrington Cancer Research and Treatment Center
Lubbock, Texas, 79410-1894
Status
Address
Texas Oncology, PA at Texas Cancer Center - Sherman
Sherman, Texas, 75090
Status
Address
Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
Sugar Land, Texas, 77479
Status
Address
American Fork Hospital
American Fork, Utah, 84003
Status
Address
Sandra L. Maxwell Cancer Center
Cedar City, Utah, 84720
Status
Address
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
Murray, Utah, 84157
Status
Address
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
Ogden, Utah, 84403
Status
Address
Utah Valley Regional Medical Center - Provo
Provo, Utah, 84604
Status
Address
Dixie Regional Medical Center - East Campus
Saint George, Utah, 84770
Status
Address
LDS Hospital
Salt Lake City, Utah, 84103
Status
Address
Utah Cancer Specialists at UCS Cancer Center
Salt Lake City, Utah, 84106
Status
Address
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, 84112
Status
Address
Fletcher Allen Health Care - University Health Center Campus
Burlington, Vermont, 05401
Status
Address
Norris Cotton Cancer Center - North
Saint Johnsbury, Vermont, 05819
Status
Address
Fredericksburg Oncology, Incorporated
Fredericksburg, Virginia, 22401
Status
Address
Sentara Cancer Institute at Sentara Norfolk General Hospital
Norfolk, Virginia, 23507
Status
Address
Virginia Commonwealth University Massey Cancer Center
Richmond, Virginia, 23298-0037
Status
Address
St. Joseph Cancer Center
Bellingham, Washington, 98225
Status
Address
St. Francis Hospital
Federal Way, Washington, 98003
Status
Address
Cascade Cancer Center at Evergreen Hospital Medical Center
Kirkland, Washington, 98033
Status
Address
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101
Status
Address
University Cancer Center at University of Washington Medical Center
Seattle, Washington, 98195-6043
Status
Address
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, 98668
Status
Address
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902
Status
Address
Theda Care Cancer Institute
Appleton, Wisconsin, 54911
Status
Address
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54301-3526
Status
Address
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, 54303
Status
Address
St. Mary's Hospital Medical Center - Green Bay
Green Bay, Wisconsin, 54303
Status
Address
St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54307-3508
Status
Address
Gundersen Lutheran Center for Cancer and Blood
La Crosse, Wisconsin, 54601
Status
Address
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164
Status
Address
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, 54143
Status
Address
Community Memorial Hospital Cancer Care Center
Menomonee Falls, Wisconsin, 53051
Status
Address
Regional Cancer Center at Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Status
Address
Green Bay Oncology, Limited - Oconto Falls
Oconto Falls, Wisconsin, 54154
Status
Address
Door County Cancer Center at Door County Memorial Hospital
Sturgeon Bay, Wisconsin, 54235-1495
Status
Address
Green Bay Oncology, Limited - Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235
Status
Address
Waukesha Memorial Hospital Regional Cancer Center
Waukesha, Wisconsin, 53188
International Sites
Status
Address
Tom Baker Cancer Centre - Calgary
Calgary, Alberta, T2N 4N2
Status
Address
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9
Status
Address
Saint John Regional Hospital
Saint John, New Brunswick, E2L 4L2
Status
Address
Margaret and Charles Juravinski Cancer Centre
Hamilton, Ontario, L8V 5C2
Status
Address
Ottawa Hospital Regional Cancer Centre - General Campus
Ottawa, Ontario, K1Y 4K7
Status
Address
Cancer Care Program at Thunder Bay Regional Health Sciences
Thunder Bay, Ontario, P7B 6V4
Status
Address
Princess Margaret Hospital
Toronto, Ontario, M5G 2M9
Status
Address
McGill Cancer Centre at McGill University
Montreal, Quebec, H2W 1S6
Status
Address
Centre Hospitalier Universitaire de Quebec
Quebec City, Quebec, G1R 2J6
Status
Address
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, S4T 7T1
