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Dasatinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Study Purpose

This phase II trial studies how well dasatinib works in treating patients with glioblastoma multiforme or gliosarcoma that has come back. Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Histologically proven diagnosis of GBM; gliosarcoma is also an eligible diagnosis.
  • - The patient must consent to submission of tissue for central pathology review.
  • - Patients who have already undergone central pathology review through their enrollment on another Radiation Therapy Oncology Group (RTOG) GBM trial do not need to consent to having their material re-reviewed by the central pathologist for this study.
  • - All patients must consent to molecular analysis of pre-dasatinib tumor tissue.
  • - Patients accrued to stage I (closed to accrual) or stage IB (opened to accrual May 5, 2009) must have tumors overexpressing at least 2 known dasatinib targets (i.e., SRC proto-oncogene, non-receptor tyrosine kinase [SRC], v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KIT], platelet-derived growth factor receptor [PDGFR], or ephrin type-A receptor 2 [EPHA2]) - Patients accrued to stage II (cohort closed; not currently applicable) do not require overexpression of SRC, KIT, PDGFR, or EPHA2.
  • - History and physical examination, including height and weight, within 10 days prior to registration on study.
  • - Brain magnetic resonance imaging (MRI) with and without gadolinium within 10 days prior to registration on study.
  • - Contrast-enhanced computed tomography (CT) scans are allowed for patients who cannot undergo MRI scanning.
  • - Karnofsky performance status >= 60.
  • - Absolute neutrophil count (ANC) >= 1,000 cells/mm^3.
  • - Platelets >= 75,000 cells/mm^3.
  • - Hemoglobin (Hgb) >= 8.0 g/dl; (note: the use of transfusion or other intervention to achieve Hgb >= 8.0 g/dl is acceptable) - Leukocytes >= 3,000 cells/mm^3.
  • - Absolute lymphocyte count (ALC) >= 500 cells/mm^3.
  • - Total bilirubin =< 1.5 X institutional upper limit of normal (ULN) - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 institutional upper limit of normal.
  • - Creatinine =< 3 X institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal.
  • - All patients must have undergone prior treatment with radiotherapy and temozolomide; no other prior treatments are allowed.
  • - There must be unequivocal radiographic evidence for tumor progression by MRI or CT scan, and the same type of scan (i.e., MRI or CT) must be used throughout the period of protocol treatment for tumor measurement; patients must be on a stable or decreasing dose of corticosteroids for at least 5 days before the baseline MRI/CT is performed.
  • - Patients having undergone recent surgery for recurrent/progressive disease are eligible as long as they have recovered from the effects of surgery; patients who recently underwent resection without measurable disease post-operatively are also eligible.
  • - Measurable disease is not required for eligibility in patients who recently underwent resection as long as the following conditions are met as applicable: - Progression of disease led to the surgery.
  • - Gliadel wafers were not placed during the most recent surgery.
  • - Neither convection enhanced delivery nor catheters for infusion of chemotherapy were used during the most recent surgery.
  • - Radioactive seeds were not placed during the most recent surgery.
  • - The histology of the most recent surgery documented recurrent/persistent/progressive malignant glioma.
  • - Women of childbearing potential must have a negative beta human chorionic gonadotropin (B HCG) pregnancy test =< 3 days prior to registration.
  • - Patient must sign study-specific informed consent prior to study entry.

Exclusion Criteria:

  • - Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years; (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible) - Radiotherapy within 4 weeks or temozolomide within 14 days prior to registration or failure to recover from adverse events of either radiotherapy or temozolomide.
  • - Patients may not be receiving any other investigational agents.
  • - Severe, active comorbidity, defined as follows: - Any clinically significant cardiovascular disease including the following: - Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months.
  • - Transmural myocardial infarction or ventricular tachyarrhythmia within the past 6 months.
  • - Prolonged corrected QT interval (QTc) > 480 msec (Fridericia correction) - Ejection fraction less than institutional normal.
  • - Major conduction abnormality (unless a cardiac pacemaker is present) - Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration.
  • - Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration.
  • - Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol.
  • - Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; breastfeeding should be discontinued if the mother is treated with dasatinib.
  • - History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib.
  • - Patients who require concurrent treatment with any medications or substances that are potent inhibitors or inducers of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) are ineligible.
  • - Patients must not be taking hepatic enzyme inducing antiepileptic drugs (EIAEDs); if patients were previously on EIAEDs that have been discontinued, patients must have been off EIAEDs for >= 2 weeks prior to initiation of dasatinib.
  • - Patients who require antacids should use short-acting, locally active agents (e.g., Maalox, Mylanta etc.); however, these agents should not be taken within either 2 hours before or 2 hours after the dasatinib dose.
  • - Use of antithrombotic and/or antiplatelet agents (e.g., warfarin, heparin, low molecular weight heparin, aspirin, clopidogrel, ticlopidine, Aggrenox) - Use of ibuprofen or non-steroidal anti-inflammatory drugs (NSAIDs) - Patients with any condition (e.g., gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for intravenous [IV] alimentation, prior surgical procedures affecting absorption, or active peptic ulcer disease) that impairs their ability to swallow and retain dasatinib tablets are excluded.
- Prior treatment with stereotactic radiosurgery (including Gamma-Knife, Cyberknife, or other variants) or brachytherapy

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT00423735
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

National Cancer Institute (NCI)
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Andrew Lassman
Principal Investigator Affiliation NRG Oncology
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

NIH, Other
Overall Status Completed
Countries Canada, Saudi Arabia, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Neoplasm
Additional Details

PRIMARY OBJECTIVES:

  • I. To determine the therapeutic efficacy of dasatinib in all patients (i.e., stages 1B and 2 combined) with recurrent/progressive glioblastoma (GBM) as measured by 6-month progression-free survival.
SECONDARY OBJECTIVES:
  • I. To determine the therapeutic efficacy of dasatinib for stage 1B patients with recurrent/progressive GBM as measured by a hybrid endpoint of 6-month progression-free survival OR objective response of (complete response [CR] or partial response [PR]) rate.
  • II. To determine patient overall survival.
  • III. To determine the toxicity of dasatinib in the treatment of patients with GBM.
  • IV. To determine radiographic response rate to treatment.
  • V. To determine patient progression-free survival.
  • VI. To explore molecular correlates of clinical outcome.
  • VII. To explore pharmacokinetic correlates of dosing, toxicity, and efficacy.
OUTLINE: Patients receive dasatinib orally (PO) twice daily (BID) on days 1-28. Courses repeat every 28 days in the absence of disease progression and unacceptable toxicity. After the completion of study treatment, patients are followed up periodically.

Arms & Interventions

Arms

Experimental: Treatment (dasatinib)

Patients receive dasatinib PO BID on days 1-28. Courses repeat every 28 days in the absence of disease progression and unacceptable toxicity.

Interventions

Drug: - Dasatinib

Given PO

Other: - Pharmacological Study

Correlative studies

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Mobile Infirmary Medical Center, Mobile, Alabama

Status

Address

Mobile Infirmary Medical Center

Mobile, Alabama, 36607

Arizona Oncology Services Foundation, Scottsdale, Arizona

Status

Address

Arizona Oncology Services Foundation

Scottsdale, Arizona, 85260

Tucson, Arizona

Status

Address

The University of Arizona Medical Center-University Campus

Tucson, Arizona, 85724

Auburn, California

Status

Address

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603

Cameron Park, California

Status

Address

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682

Mercy San Juan Medical Center, Carmichael, California

Status

Address

Mercy San Juan Medical Center

Carmichael, California, 95608

City of Hope Comprehensive Cancer Center, Duarte, California

Status

Address

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

Glendale Adventist Medical Center, Glendale, California

Status

Address

Glendale Adventist Medical Center

Glendale, California, 91206

Orange, California

Status

Address

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868

Roseville, California

Status

Address

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661

Sutter Medical Center Sacramento, Sacramento, California

Status

Address

Sutter Medical Center Sacramento

Sacramento, California, 95816

Sacramento, California

Status

Address

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

Sacramento, California

Status

Address

Mercy General Hospital Radiation Oncology Center

Sacramento, California, 95819

Vacaville, California

Status

Address

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, 95687

Hartford, Connecticut

Status

Address

Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105

Beebe Medical Center, Lewes, Delaware

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Address

Beebe Medical Center

Lewes, Delaware, 19958

Newark, Delaware

Status

Address

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718

Boca Raton Regional Hospital, Boca Raton, Florida

Status

Address

Boca Raton Regional Hospital

Boca Raton, Florida, 33486

Holy Cross Hospital, Fort Lauderdale, Florida

Status

Address

Holy Cross Hospital

Fort Lauderdale, Florida, 33308

Gainesville, Florida

Status

Address

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

Jacksonville Beach, Florida

Status

Address

Integrated Community Oncology Network-Florida Cancer Center Beaches

Jacksonville Beach, Florida, 32250

Baptist MD Anderson Cancer Center, Jacksonville, Florida

Status

Address

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207

Jacksonville, Florida

Status

Address

Integrated Community Oncology Network-Southside Cancer Center

Jacksonville, Florida, 32207

Jacksonville, Florida

Status

Address

University of Florida Health Science Center - Jacksonville

Jacksonville, Florida, 32209

Baptist Medical Center South, Jacksonville, Florida

Status

Address

Baptist Medical Center South

Jacksonville, Florida, 32258

Jupiter Medical Center, Jupiter, Florida

Status

Address

Jupiter Medical Center

Jupiter, Florida, 33458

Mount Sinai Medical Center, Miami Beach, Florida

Status

Address

Mount Sinai Medical Center

Miami Beach, Florida, 33140

21st Century Oncology-Orange Park, Orange Park, Florida

Status

Address

21st Century Oncology-Orange Park

Orange Park, Florida, 32073

21st Century Oncology-Palatka, Palatka, Florida

Status

Address

21st Century Oncology-Palatka

Palatka, Florida, 32177

Bay Medical Center, Panama City, Florida

Status

Address

Bay Medical Center

Panama City, Florida, 32401

Saint Augustine, Florida

Status

Address

Integrated Community Oncology Network-Flager Cancer Center

Saint Augustine, Florida, 32086

John B Amos Cancer Center, Columbus, Georgia

Status

Address

John B Amos Cancer Center

Columbus, Georgia, 31904

Savannah, Georgia

Status

Address

Memorial Health University Medical Center

Savannah, Georgia, 31404

Ingalls Memorial Hospital, Harvey, Illinois

Status

Address

Ingalls Memorial Hospital

Harvey, Illinois, 60426

Saint John's Hospital, Springfield, Illinois

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Address

Saint John's Hospital

Springfield, Illinois, 62702

Anderson, Indiana

Status

Address

Saint Vincent Anderson Regional Hospital/Cancer Center

Anderson, Indiana, 46016

Beech Grove, Indiana

Status

Address

Franciscan Saint Francis Health-Beech Grove

Beech Grove, Indiana, 46107

IU Health Methodist Hospital, Indianapolis, Indiana

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Address

IU Health Methodist Hospital

Indianapolis, Indiana, 46202

Reid Health, Richmond, Indiana

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Address

Reid Health

Richmond, Indiana, 47374

Menorah Medical Center, Overland Park, Kansas

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Address

Menorah Medical Center

Overland Park, Kansas, 66209

Saint Luke's South Hospital, Overland Park, Kansas

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Address

Saint Luke's South Hospital

Overland Park, Kansas, 66213

Prairie Village, Kansas

Status

Address

Kansas City NCI Community Oncology Research Program

Prairie Village, Kansas, 66208

Shawnee Mission Medical Center-KCCC, Shawnee Mission, Kansas

Status

Address

Shawnee Mission Medical Center-KCCC

Shawnee Mission, Kansas, 66204

Louisville, Kentucky

Status

Address

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202

Union Hospital of Cecil County, Elkton, Maryland

Status

Address

Union Hospital of Cecil County

Elkton, Maryland, 21921

Boston Medical Center, Boston, Massachusetts

Status

Address

Boston Medical Center

Boston, Massachusetts, 02118

Ann Arbor, Michigan

Status

Address

Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan, 48106

Saint Joseph Mercy Hospital, Ann Arbor, Michigan

Status

Address

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106

Beaumont Hospital-Dearborn, Dearborn, Michigan

Status

Address

Beaumont Hospital-Dearborn

Dearborn, Michigan, 48124

Ascension Saint John Hospital, Detroit, Michigan

Status

Address

Ascension Saint John Hospital

Detroit, Michigan, 48236

Green Bay Oncology - Escanaba, Escanaba, Michigan

Status

Address

Green Bay Oncology - Escanaba

Escanaba, Michigan, 49829

Hurley Medical Center, Flint, Michigan

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Address

Hurley Medical Center

Flint, Michigan, 48503

Flint, Michigan

Status

Address

Genesys Regional Medical Center-West Flint Campus

Flint, Michigan, 48532

Green Bay Oncology - Iron Mountain, Iron Mountain, Michigan

Status

Address

Green Bay Oncology - Iron Mountain

Iron Mountain, Michigan, 49801

Allegiance Health, Jackson, Michigan

Status

Address

Allegiance Health

Jackson, Michigan, 49201

Bronson Methodist Hospital, Kalamazoo, Michigan

Status

Address

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

West Michigan Cancer Center, Kalamazoo, Michigan

Status

Address

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

Borgess Medical Center, Kalamazoo, Michigan

Status

Address

Borgess Medical Center

Kalamazoo, Michigan, 49048

Sparrow Hospital, Lansing, Michigan

Status

Address

Sparrow Hospital

Lansing, Michigan, 48912

Saint Mary Mercy Hospital, Livonia, Michigan

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Address

Saint Mary Mercy Hospital

Livonia, Michigan, 48154

Saint Joseph Mercy Oakland, Pontiac, Michigan

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Address

Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341

Lake Huron Medical Center, Port Huron, Michigan

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Address

Lake Huron Medical Center

Port Huron, Michigan, 48060

Saint Mary's of Michigan, Saginaw, Michigan

Status

Address

Saint Mary's of Michigan

Saginaw, Michigan, 48601

Saint John Macomb-Oakland Hospital, Warren, Michigan

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Address

Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093

Fairview Ridges Hospital, Burnsville, Minnesota

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Address

Fairview Ridges Hospital

Burnsville, Minnesota, 55337

Mercy Hospital, Coon Rapids, Minnesota

Status

Address

Mercy Hospital

Coon Rapids, Minnesota, 55433

Fairview-Southdale Hospital, Edina, Minnesota

Status

Address

Fairview-Southdale Hospital

Edina, Minnesota, 55435

Unity Hospital, Fridley, Minnesota

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Address

Unity Hospital

Fridley, Minnesota, 55432

Hutchinson Area Health Care, Hutchinson, Minnesota

Status

Address

Hutchinson Area Health Care

Hutchinson, Minnesota, 55350

Maplewood, Minnesota

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Address

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109

Saint John's Hospital - Healtheast, Maplewood, Minnesota

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Address

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109

Abbott-Northwestern Hospital, Minneapolis, Minnesota

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Address

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407

Hennepin County Medical Center, Minneapolis, Minnesota

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Address

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

North Memorial Medical Health Center, Robbinsdale, Minnesota

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Address

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422

Saint Louis Park, Minnesota

Status

Address

Metro Minnesota Community Oncology Research Consortium

Saint Louis Park, Minnesota, 55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota

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Address

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

Regions Hospital, Saint Paul, Minnesota

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Address

Regions Hospital

Saint Paul, Minnesota, 55101

United Hospital, Saint Paul, Minnesota

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Address

United Hospital

Saint Paul, Minnesota, 55102

Saint Francis Regional Medical Center, Shakopee, Minnesota

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Address

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379

Ridgeview Medical Center, Waconia, Minnesota

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Address

Ridgeview Medical Center

Waconia, Minnesota, 55387

Woodbury, Minnesota

Status

Address

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125

Singing River Hospital, Pascagoula, Mississippi

Status

Address

Singing River Hospital

Pascagoula, Mississippi, 39581

Cape Radiation Oncology, Cape Girardeau, Missouri

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Address

Cape Radiation Oncology

Cape Girardeau, Missouri, 63703

Centerpoint Medical Center LLC, Independence, Missouri

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Address

Centerpoint Medical Center LLC

Independence, Missouri, 64057

Truman Medical Center, Kansas City, Missouri

Status

Address

Truman Medical Center

Kansas City, Missouri, 64108

Saint Luke's Hospital of Kansas City, Kansas City, Missouri

Status

Address

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111

Saint Joseph Health Center, Kansas City, Missouri

Status

Address

Saint Joseph Health Center

Kansas City, Missouri, 64114

North Kansas City Hospital, Kansas City, Missouri

Status

Address

North Kansas City Hospital

Kansas City, Missouri, 64116

Kansas City, Missouri

Status

Address

Heartland Hematology and Oncology Associates Incorporated

Kansas City, Missouri, 64118

Research Medical Center, Kansas City, Missouri

Status

Address

Research Medical Center

Kansas City, Missouri, 64132

Saint Luke's East - Lee's Summit, Lee's Summit, Missouri

Status

Address

Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086

Liberty Radiation Oncology Center, Liberty, Missouri

Status

Address

Liberty Radiation Oncology Center

Liberty, Missouri, 64068

Heartland Regional Medical Center, Saint Joseph, Missouri

Status

Address

Heartland Regional Medical Center

Saint Joseph, Missouri, 64507

Washington University School of Medicine, Saint Louis, Missouri

Status

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Saint Peters, Missouri

Status

Address

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, Missouri, 63376

Cancer Research for the Ozarks NCORP, Springfield, Missouri

Status

Address

Cancer Research for the Ozarks NCORP

Springfield, Missouri, 65804

Mercy Hospital Springfield, Springfield, Missouri

Status

Address

Mercy Hospital Springfield

Springfield, Missouri, 65804

CoxHealth South Hospital, Springfield, Missouri

Status

Address

CoxHealth South Hospital

Springfield, Missouri, 65807

Nebraska Methodist Hospital, Omaha, Nebraska

Status

Address

Nebraska Methodist Hospital

Omaha, Nebraska, 68114

Renown Regional Medical Center, Reno, Nevada

Status

Address

Renown Regional Medical Center

Reno, Nevada, 89502

Keene, New Hampshire

Status

Address

Cheshire Medical Center-Dartmouth-Hitchcock Keene

Keene, New Hampshire, 03431

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Status

Address

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756

Camden, New Jersey

Status

Address

Cooper Hospital University Medical Center

Camden, New Jersey, 08103

Virtua Memorial, Mount Holly, New Jersey

Status

Address

Virtua Memorial

Mount Holly, New Jersey, 08060

Sparta Cancer Treatment Center, Sparta, New Jersey

Status

Address

Sparta Cancer Treatment Center

Sparta, New Jersey, 07871

Virtua Voorhees, Voorhees, New Jersey

Status

Address

Virtua Voorhees

Voorhees, New Jersey, 08043

Memorial Sloan Kettering Cancer Center, New York, New York

Status

Address

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Highland Hospital, Rochester, New York

Status

Address

Highland Hospital

Rochester, New York, 14620

University of Rochester, Rochester, New York

Status

Address

University of Rochester

Rochester, New York, 14642

Charlotte, North Carolina

Status

Address

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204

Rutherford Hospital, Rutherfordton, North Carolina

Status

Address

Rutherford Hospital

Rutherfordton, North Carolina, 28139

Akron, Ohio

Status

Address

Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio, 44304

Cleveland Clinic Akron General, Akron, Ohio

Status

Address

Cleveland Clinic Akron General

Akron, Ohio, 44307

Summa Barberton Hospital, Barberton, Ohio

Status

Address

Summa Barberton Hospital

Barberton, Ohio, 44203

Aultman Health Foundation, Canton, Ohio

Status

Address

Aultman Health Foundation

Canton, Ohio, 44710

Cincinnati, Ohio

Status

Address

University of Cincinnati/Barrett Cancer Center

Cincinnati, Ohio, 45219

Grandview Hospital, Dayton, Ohio

Status

Address

Grandview Hospital

Dayton, Ohio, 45405

Good Samaritan Hospital - Dayton, Dayton, Ohio

Status

Address

Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406

Miami Valley Hospital, Dayton, Ohio

Status

Address

Miami Valley Hospital

Dayton, Ohio, 45409

Samaritan North Health Center, Dayton, Ohio

Status

Address

Samaritan North Health Center

Dayton, Ohio, 45415

Veteran Affairs Medical Center, Dayton, Ohio

Status

Address

Veteran Affairs Medical Center

Dayton, Ohio, 45428

Blanchard Valley Hospital, Findlay, Ohio

Status

Address

Blanchard Valley Hospital

Findlay, Ohio, 45840

Franklin, Ohio

Status

Address

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066

Kettering Medical Center, Kettering, Ohio

Status

Address

Kettering Medical Center

Kettering, Ohio, 45429

Salem, Ohio

Status

Address

UH Seidman Cancer Center at Salem Regional Medical Center

Salem, Ohio, 44460

Upper Valley Medical Center, Troy, Ohio

Status

Address

Upper Valley Medical Center

Troy, Ohio, 45373

University Pointe, West Chester, Ohio

Status

Address

University Pointe

West Chester, Ohio, 45069

Cancer Treatment Center, Wooster, Ohio

Status

Address

Cancer Treatment Center

Wooster, Ohio, 44691

Greene Memorial Hospital, Xenia, Ohio

Status

Address

Greene Memorial Hospital

Xenia, Ohio, 45385

Oklahoma City, Oklahoma

Status

Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Salem Hospital, Salem, Oregon

Status

Address

Salem Hospital

Salem, Oregon, 97301

Abington Memorial Hospital, Abington, Pennsylvania

Status

Address

Abington Memorial Hospital

Abington, Pennsylvania, 19001

Delaware County Memorial Hospital, Drexel Hill, Pennsylvania

Status

Address

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, 19026

Northeast Radiation Oncology Center, Dunmore, Pennsylvania

Status

Address

Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512

Adams Cancer Center, Gettysburg, Pennsylvania

Status

Address

Adams Cancer Center

Gettysburg, Pennsylvania, 17325

Cherry Tree Cancer Center, Hanover, Pennsylvania

Status

Address

Cherry Tree Cancer Center

Hanover, Pennsylvania, 17331

Hershey, Pennsylvania

Status

Address

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850

Upper Delaware Valley Cancer Center, Milford, Pennsylvania

Status

Address

Upper Delaware Valley Cancer Center

Milford, Pennsylvania, 18337

Reading Hospital, West Reading, Pennsylvania

Status

Address

Reading Hospital

West Reading, Pennsylvania, 19611

WellSpan Health-York Hospital, York, Pennsylvania

Status

Address

WellSpan Health-York Hospital

York, Pennsylvania, 17403

AnMed Health Hospital, Anderson, South Carolina

Status

Address

AnMed Health Hospital

Anderson, South Carolina, 29621

Medical University of South Carolina, Charleston, South Carolina

Status

Address

Medical University of South Carolina

Charleston, South Carolina, 29425

Saint Francis Hospital, Greenville, South Carolina

Status

Address

Saint Francis Hospital

Greenville, South Carolina, 29601

Greenville, South Carolina

Status

Address

Greenville Health System Cancer Institute-Eastside

Greenville, South Carolina, 29615

Spartanburg Medical Center, Spartanburg, South Carolina

Status

Address

Spartanburg Medical Center

Spartanburg, South Carolina, 29303

Rapid City Regional Hospital, Rapid City, South Dakota

Status

Address

Rapid City Regional Hospital

Rapid City, South Dakota, 57701

Kingsport, Tennessee

Status

Address

Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660

Thompson Cancer Survival Center, Knoxville, Tennessee

Status

Address

Thompson Cancer Survival Center

Knoxville, Tennessee, 37916

Thompson Cancer Survival Center - West, Knoxville, Tennessee

Status

Address

Thompson Cancer Survival Center - West

Knoxville, Tennessee, 37932

Oak Ridge, Tennessee

Status

Address

Thompson Cancer Survival Center at Methodist

Oak Ridge, Tennessee, 37830

University of Texas Medical Branch, Galveston, Texas

Status

Address

University of Texas Medical Branch

Galveston, Texas, 77555-0565

M D Anderson Cancer Center, Houston, Texas

Status

Address

M D Anderson Cancer Center

Houston, Texas, 77030

Covenant Medical Center-Lakeside, Lubbock, Texas

Status

Address

Covenant Medical Center-Lakeside

Lubbock, Texas, 79410

American Fork, Utah

Status

Address

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003

Sandra L Maxwell Cancer Center, Cedar City, Utah

Status

Address

Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720

Logan Regional Hospital, Logan, Utah

Status

Address

Logan Regional Hospital

Logan, Utah, 84321

Cottonwood Hospital Medical Center, Murray, Utah

Status

Address

Cottonwood Hospital Medical Center

Murray, Utah, 84107

Intermountain Medical Center, Murray, Utah

Status

Address

Intermountain Medical Center

Murray, Utah, 84107

McKay-Dee Hospital Center, Ogden, Utah

Status

Address

McKay-Dee Hospital Center

Ogden, Utah, 84403

Utah Valley Regional Medical Center, Provo, Utah

Status

Address

Utah Valley Regional Medical Center

Provo, Utah, 84604

Saint George, Utah

Status

Address

Dixie Medical Center Regional Cancer Center

Saint George, Utah, 84770

Intermountain Health Care, Salt Lake City, Utah

Status

Address

Intermountain Health Care

Salt Lake City, Utah, 84103

Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah

Status

Address

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106

Salt Lake City, Utah

Status

Address

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

LDS Hospital, Salt Lake City, Utah

Status

Address

LDS Hospital

Salt Lake City, Utah, 84143

University of Vermont Medical Center, Burlington, Vermont

Status

Address

University of Vermont Medical Center

Burlington, Vermont, 05401

Burlington, Vermont

Status

Address

University of Vermont College of Medicine

Burlington, Vermont, 05405

Norris Cotton Cancer Center-North, Saint Johnsbury, Vermont

Status

Address

Norris Cotton Cancer Center-North

Saint Johnsbury, Vermont, 05819

Southwest VA Regional Cancer Center, Norton, Virginia

Status

Address

Southwest VA Regional Cancer Center

Norton, Virginia, 24273

Richmond, Virginia

Status

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Yakima, Washington

Status

Address

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902

Wheeling, West Virginia

Status

Address

Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003

Green Bay, Wisconsin

Status

Address

Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, 54301-3526

Green Bay, Wisconsin

Status

Address

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301

Green Bay, Wisconsin

Status

Address

Green Bay Oncology Limited at Saint Mary's Hospital

Green Bay, Wisconsin, 54303

Green Bay, Wisconsin

Status

Address

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

Status

Address

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Madison, Wisconsin

Status

Address

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792

Bay Area Medical Center, Marinette, Wisconsin

Status

Address

Bay Area Medical Center

Marinette, Wisconsin, 54143

Milwaukee, Wisconsin

Status

Address

Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin

Status

Address

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066

Green Bay Oncology - Oconto Falls, Oconto Falls, Wisconsin

Status

Address

Green Bay Oncology - Oconto Falls

Oconto Falls, Wisconsin, 54154

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay, Wisconsin

Status

Address

Green Bay Oncology - Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235

ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin

Status

Address

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188

International Sites

London Regional Cancer Program, London, Ontario, Canada

Status

Address

London Regional Cancer Program

London, Ontario, N6A 4L6

Quebec City, Quebec, Canada

Status

Address

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Quebec City, Quebec, G1R 2J6

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Status

Address

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1

Riyadh, Saudi Arabia

Status

Address

King Faisal Specialist Hospital and Research Centre

Riyadh, , 11211