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DISEASE CHARACTERISTICS:

• - Newly diagnosed high-grade glioma, including the following subtypes: - Anaplastic astrocytoma.

• - Anaplastic oligodendroglioma.

• - Glioblastoma multiforme.

• - Requires dexamethasone at a dose of > 4 mg/day to control symptoms of tumor-related edema at time of study enrollment AND has been on a stable dose of steroids for ≥ 5 days prior to study enrollment.

• - Completed ≥ 80% of prescribed radiotherapy.

• - Hypogonadal, defined as serum testosterone level < 350 ng/dL.

• - No history of prostate or breast cancer.

• - No benign prostatic hypertrophy requiring therapy OR AUA score of ≥ 8.

• - PSA ≤ 4 ng/mL.

PATIENT CHARACTERISTICS:

• - Karnofsky performance status 60-100% - Able to keep daily records or has a care provider that agrees to keep daily records of drug administration.

• - No clinical history of congestive heart failure requiring therapy.

• - No psychotic disorder requiring active treatment.

• - No structured exercise program involving exercise for > 3 hours/week.

- No polycythemia (i.e., hematocrit > 52%) PRIOR CONCURRENT THERAPY: - More than 6 months since prior androgen therapy

OBJECTIVES: Primary.

• - To determine if daily administration of testosterone gel can prevent the development or reduce the severity of muscle weakness in men receiving glucocorticoids for newly diagnosed high-grade glioma.

Secondary.

• - To compare the difference in percent change from baseline timed functional tests (TFT) between patients who are treated with testosterone gel and those who are not.

• - To compare the difference in percent change from baseline activities of daily living as assessed by the Health Assessment Questionnaire-Disability Index (HAQ-DI) between patients who are treated with testosterone gel and those who are not.

• - To compare the difference in percent change from baseline leg muscle mass as assessed by CT scan imaging between patients who are treated with testosterone gel and those who are not.

• - To estimate the side effects of testosterone gel in these patients.

OUTLINE: Patients are stratified according to daily glucocorticoid dose (< 16 mg/day vs.#46;≥ 16 mg/day), Karnofsky performance status (≤ 80% vs.#46;> 80%), and age (≤ 50 years of age vs.#46; > 50 years of age). Patients are randomized to 1 of 2 treatment arms.

• - Arm I (control): Patients receive oral whey protein powder once daily for 7 months.

• - Arm II (treatment): Patients apply topical testosterone gel to the shoulder, upper chest, or forearm once daily for 7 months.

Patients undergo strength testing and functional testing (TFT) and complete an activities of daily living questionnaire at baseline and at 1, 3, 5, and 7 months. Patients also undergo CT scan of the leg and laboratory testing at baseline and at 3 and 7 months. Testosterone levels are obtained at baseline and at 1, 3, and 7 months. Patients complete a daily log of their glucocorticoid dose and to affirm compliance with therapy. Major clinical events related to underlying tumor (i.e., surgery, radiotherapy, initiating chemotherapy, concurrent antiepileptic therapy, deep vein thrombosis, pulmonary embolism, transfusions, seizures, pneumonia, and other forms of infection) are also recorded.

Arms

Placebo Comparator: Arm 1: Control Group

whey protein powder

Active Comparator: ARM 2 : Treatment Group

Testosterone Gel (10g pouch/day) applied to skin

Interventions

Drug: - testosterone gel applied to skin

Application of testosterone gel

Dietary Supplement: - whey powder protein