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Dasatinib or Placebo, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Study Purpose

Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It may also make tumor cells more sensitive to radiation therapy. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. This randomized phase I/II trial is studying the best dose of dasatinib and to see how well it works compared with a placebo when given together with radiation therapy and temozolomide in treating patients with newly diagnosed glioblastoma multiforme.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Pre-registration

Inclusion Criteria:

1. Central Pathology Review
  • - Central pathology review submission.
This review is mandatory prior to registration to confirm eligibility. Registration

Inclusion Criteria:

1. Age ≥ 18 years. 2. Histological Confirmation of Glioblastoma
  • - Histologically confirmed newly diagnosed glioblastoma (GBM) (grade 4 astrocytoma) as determined by pre-registration central pathology review.
Note: GBM with oligodendroglial features are not permitted in this study if they are 1p19q codeleted. Sites submitting GBM with oligodendroglial features will be asked to provide results of 1p/19q codeletion status. 3. Measurable or Evaluable Disease
  • - Measurable or evaluable disease by gadolinium MRI or contrast CT scan.
Note: Patients who have had a gross total resection are eligible on the basis of evaluable disease. 4. ECOG Performance Status 0, 1 or 2. 5. Required Laboratory Values: The following laboratory values obtained ≤ 14 days prior to registration.
  • - Absolute neutrophil count (ANC) ≥ 1500/mm3.
  • - Platelet count ≥ 100,000/mm3.
  • - Hemoglobin > 9.0 g/dL.
  • - Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) - SGOT (AST) ≤ 2.5 x ULN.
  • - Creatinine ≤ 1.5 x ULN.
6. Required INR Value: The following INR value obtained ≤ 28 days prior to registration.
  • - INR ≤ 1.5.
7. Urine or Serum Pregnancy Test
  • - Negative urine or serum pregnancy test done ≤ 7 days prior to registration, for women of childbearing potential only.
8. Written Informed Consent
  • - Patient must provide written informed consent.
9. Return to Enrolling Institution
  • - Patient must be willing to return to Alliance enrolling institution for follow-up.
10. Tissue Samples
  • - Patient must be willing to provide tissue samples for research purposes.
11. Patient must be willing to provide tissue samples for research purposes. 12. Required Antibiotic Prophylaxis
  • - Patient must be willing to comply with antibiotic prophylaxis with trimethoprim/sulfamethoxazole, pentamidine or dapsone.
13. Grapefruit and Grapefruit Juice
  • - Patient must be willing to abstain from eating grapefruit or drinking grapefruit juice for the duration of the study treatment.
14. Ability to Swallow
  • - Patient must have the ability to take oral medication (dasatinib must be swallowed whole).
15. Quality of Life (QOL) Questionnaires
  • - Phase II patients only: Patients must be willing and able to complete QOL questionnaires independently or with the help of a caregiver.
16. Other Anti-Tumor Drug Therapies
  • - Patient must be willing to forego other cytotoxic and non-cytotoxic drug therapy against the tumor while being treated with dasatinib and temozolomide.
Registration

Exclusion Criteria:

1. Pregnancy, Nursing and Required Contraception
  • - Any of the following because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown: - Pregnant women.
  • - Nursing women.
  • - Men or women of childbearing potential who are unwilling to employ adequate contraception throughout study treatment and for at least 12 weeks after study drug is stopped.
2. Prior Radiotherapy or Chemotherapy for Any CNS Neoplasm
  • - Received any prior radiotherapy or chemotherapy for any CNS neoplasm (hormones, vitamins and growth factors are not considered chemotherapy for the purposes of this study.
3. Prior Surgery for Any CNS Neoplasm
  • - Prior surgeries for any CNS neoplasms, other than surgery related to the current GBM diagnosis.
Note: If Gliadel wafers are placed at time of primary resection, this would be considered prior therapy and patient would be ineligible. 4. Concurrent Illness or Disease
  • - Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
Including but not limited to:
  • - History of bleeding diathesis.
  • - Current use of chronic systemic anticoagulation therapy that cannot be discontinued (antiplatelet agents, Aspirin) - Current chronic use of NSAIDs which cannot be discontinued.
5. Pleural or Pericardial Effusions
  • - Pleural or pericardial effusion of any grade.
6. Immunocompromised Status
  • - Immunocompromised patients (other than that related to the use of corticosteroids) and patients known to be HIV positive and currently receiving antiretroviral therapy.
Note: Patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for this trial. 7. Uncontrolled Intercurrent Illness
  • - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
8. Other Investigational Agents
  • - Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm.
9. Other Active Malignancies
  • - Other active malignancy ≤ 5 years prior to registration.
Exceptions: Non-melanotic skin cancer or carcinoma-in-situ of the cervix. Note: If there is a history of prior malignancy, they must not be receiving other specific treatment other than hormonal therapy for their cancer. 10. History of Cardiac or Metabolic Conditions:
  • - Myocardial infarction ≤ 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias.
  • - Diagnosed congenital long QT syndrome.
  • - Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes) - Prolonged QTc interval on pre-entry electrocardiogram (> 450 msec) - Patients with hypokalemia or hypomagnesemia if it cannot be corrected prior to dasatinib administration.
11. Clinically Significant Cardiovascular Disease
  • - Patients may not have any clinically significant cardiovascular disease including the following: - Myocardial infarction or ventricular tachyarrhythmia within 6 months.
  • - Ejection fraction less than institutional normal.
  • - Major conduction abnormality (unless a cardiac pacemaker is present) Note: Patients with any cardiopulmonary symptoms of unknown cause (e.g., shortness of breath, chest pain, etc.) should be evaluated by a baseline echocardiogram with or without stress test as needed in addition to ECG to rule out QTc prolongation.
The patient may be referred to a cardiologist at the discretion of the principal investigator. Patients with underlying cardiopulmonary dysfunction should be excluded from the study. 12. Congestive Heart Failure
  • - New York Heart Association classification ≥ Class II Congestive Heart Failure.
13. Prohibited or Restricted Concomitant Treatments
  • - Currently taking one of the following medications: - Enzyme inducing anti-convulsants (EIACs) Note: To be eligible, patient must be switched to non-EIAC medications ≥7 days prior to registration.
See protocol for a list of EIAC and non-EIAC medications.
  • - Potent inhibitors of CYP3A4 which cannot be discontinued.
See protocol for a list of medications known to inhibit CYP3A4.
  • - Medications known to prolong QT interval which cannot be discontinued or switched.
See Appendix II for a list of medications which are known to prolong the QT interval.
  • - Medications that may possibly prolong QT interval and produce a QTc that is ≥ 60 msec or a QTcF that is ≥ 450 msec.
See Appendix II for a list of medications that may possibly prolong QTc.
  • - St. John's Wort.
  • - H2 blockers or proton pump inhibitors (PPIs), such as famotidine (Pepcid) and omeprazole (Prilosec) respectively, which cannot be discontinued or switched to locally acting agents, such as Maalox, Mylanta and TUMS.
14. Allergy to Antibiotic Prophylaxis Medications
  • - Severe allergy to sulfa medications and dapsone and pentamidine.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT00869401
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 1/Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Alliance for Clinical Trials in Oncology
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Nadia N. Laack, MD
Principal Investigator Affiliation Mayo Clinic
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other, NIH, Industry
Overall Status Completed
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Brain and Central Nervous System Tumors
Additional Details

This trial includes a phase I dose-escalation study and a double-blind randomized phase II trial for patients with newly diagnosed glioblastoma multiforme (GBM). Phase I will be a cohort of 3 dose-escalation trial of dasatinib in combination with radiation and concomitant temozolomide. Patients receive concomitant chemotherapy and radiation therapy for cycle one. Patients receive adjuvant chemotherapy 28-42 days post cycle one treatment. Patients receive only dasatinib post cycle 8 treatment until progressive disease, unacceptable adverse events or refusal. Phase II will be a randomized trial with two treatment arms. Patients will be randomized at the time of registration at a ratio of 1:2 respectively to either standard therapy arm (continuous daily placebo prior, during and after standard radiotherapy/temozolomide followed by temozolomide. For more information please see the Arms section. The primary objectives are listed below. Primary Objectives: 1. To establish a maximum tolerated dose of dasatinib combined with radiation and temozolomide in this patient population (Phase I) 2. To determine the efficacy of dasatinib in combination with radiotherapy and concomitant and adjuvant temozolomide in patients with newly diagnosed glioblastoma, and compare it with the standard of care approach in the treatment of these patients consisting of radiotherapy and temozolomide, followed by adjuvant temozolomide (Phase II) Patients are followed for 5 years post treatment. The study permanently closed to accrual on January 31, 2014.

Arms & Interventions

Arms

Experimental: Group 1 (Phase II) dasatinib + radiation + temozolomide

Patients receive concomitant chemotherapy and radiation for cycle one for a total of 42 days, then patients receive adjuvant chemotherapy 28-42 days post cycle one treatment. Patients receive only dasatinib post cycle 8 until progressive disease, unacceptable adverse events or refusal.

Active Comparator: Group 2 (Phase II) placebo + radiation + temozolomide

Patients receive concomitant chemotherapy and radiation for cycle one for a total of 42 days, then patients receive adjuvant chemotherapy 28-42 days post cycle one treatment. Patients receive only placebo post cycle 8 until progressive disease, unacceptable adverse events or refusal.

Interventions

Drug: - dasatinib

Given orally

Drug: - temozolomide

Given orally

Other: - placebo

Given orally

Radiation: - radiation therapy

Radiation therapy is performed as 30 fractions of 200 cGy for a total of 6000 cGy.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Hartford, Connecticut

Status

Address

Helen and Harry Gray Cancer Center at Hartford Hospital

Hartford, Connecticut, 06102-5037

Mayo Clinic - Jacksonville, Jacksonville, Florida

Status

Address

Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224

John B. Amos Cancer Center, Columbus, Georgia

Status

Address

John B. Amos Cancer Center

Columbus, Georgia, 31904

Illinois CancerCare - Bloomington, Bloomington, Illinois

Status

Address

Illinois CancerCare - Bloomington

Bloomington, Illinois, 61701

St. Joseph Medical Center, Bloomington, Illinois

Status

Address

St. Joseph Medical Center

Bloomington, Illinois, 61701

Illinois CancerCare - Canton, Canton, Illinois

Status

Address

Illinois CancerCare - Canton

Canton, Illinois, 61520

Illinois CancerCare - Carthage, Carthage, Illinois

Status

Address

Illinois CancerCare - Carthage

Carthage, Illinois, 62321

Resurrection Medical Center, Chicago, Illinois

Status

Address

Resurrection Medical Center

Chicago, Illinois, 60631

Eureka Community Hospital, Eureka, Illinois

Status

Address

Eureka Community Hospital

Eureka, Illinois, 61530

Illinois CancerCare - Eureka, Eureka, Illinois

Status

Address

Illinois CancerCare - Eureka

Eureka, Illinois, 61530

Galesburg Clinic, PC, Galesburg, Illinois

Status

Address

Galesburg Clinic, PC

Galesburg, Illinois, 61401

Illinois CancerCare - Havana, Havana, Illinois

Status

Address

Illinois CancerCare - Havana

Havana, Illinois, 62644

Illinois CancerCare - Kewanee Clinic, Kewanee, Illinois

Status

Address

Illinois CancerCare - Kewanee Clinic

Kewanee, Illinois, 61443

Illinois CancerCare - Macomb, Macomb, Illinois

Status

Address

Illinois CancerCare - Macomb

Macomb, Illinois, 61455

Illinois CancerCare - Monmouth, Monmouth, Illinois

Status

Address

Illinois CancerCare - Monmouth

Monmouth, Illinois, 61462

OSF Holy Family Medical Center, Monmouth, Illinois

Status

Address

OSF Holy Family Medical Center

Monmouth, Illinois, 61462

BroMenn Regional Medical Center, Normal, Illinois

Status

Address

BroMenn Regional Medical Center

Normal, Illinois, 61761

Community Cancer Center, Normal, Illinois

Status

Address

Community Cancer Center

Normal, Illinois, 61761

Normal, Illinois

Status

Address

Illinois CancerCare - Community Cancer Center

Normal, Illinois, 61761

Community Hospital of Ottawa, Ottawa, Illinois

Status

Address

Community Hospital of Ottawa

Ottawa, Illinois, 61350

Ottawa, Illinois

Status

Address

Oncology Hematology Associates of Central Illinois, PC - Ottawa

Ottawa, Illinois, 61350

Pekin, Illinois

Status

Address

Cancer Treatment Center at Pekin Hospital

Pekin, Illinois, 61554

Illinois CancerCare - Pekin, Pekin, Illinois

Status

Address

Illinois CancerCare - Pekin

Pekin, Illinois, 61603

Proctor Hospital, Peoria, Illinois

Status

Address

Proctor Hospital

Peoria, Illinois, 61614

OSF St. Francis Medical Center, Peoria, Illinois

Status

Address

OSF St. Francis Medical Center

Peoria, Illinois, 61615-7827

Peoria, Illinois

Status

Address

CCOP - Illinois Oncology Research Association

Peoria, Illinois, 61615

Peoria, Illinois

Status

Address

Oncology Hematology Associates of Central Illinois, PC - Peoria

Peoria, Illinois, 61615

Methodist Medical Center of Illinois, Peoria, Illinois

Status

Address

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

Illinois CancerCare - Peru, Peru, Illinois

Status

Address

Illinois CancerCare - Peru

Peru, Illinois, 61354

Illinois Valley Community Hospital, Peru, Illinois

Status

Address

Illinois Valley Community Hospital

Peru, Illinois, 61354

Illinois CancerCare - Princeton, Princeton, Illinois

Status

Address

Illinois CancerCare - Princeton

Princeton, Illinois, 61356

Illinois CancerCare - Spring Valley, Spring Valley, Illinois

Status

Address

Illinois CancerCare - Spring Valley

Spring Valley, Illinois, 61362

Valley Cancer Center, Spring Valley, Illinois

Status

Address

Valley Cancer Center

Spring Valley, Illinois, 61362

CCOP - Carle Cancer Center, Urbana, Illinois

Status

Address

CCOP - Carle Cancer Center

Urbana, Illinois, 61801

Elkhart Clinic, LLC, Elkhart, Indiana

Status

Address

Elkhart Clinic, LLC

Elkhart, Indiana, 46514-2098

Elkhart, Indiana

Status

Address

Michiana Hematology-Oncology, PC - Elkhart

Elkhart, Indiana, 46514

Elkhart General Hospital, Elkhart, Indiana

Status

Address

Elkhart General Hospital

Elkhart, Indiana, 46515

Indianapolis, Indiana

Status

Address

St. Francis Hospital Cancer Care Services

Indianapolis, Indiana, 46237

Howard Community Hospital, Kokomo, Indiana

Status

Address

Howard Community Hospital

Kokomo, Indiana, 46904

La Porte, Indiana

Status

Address

Center for Cancer Therapy at LaPorte Hospital and Health Services

La Porte, Indiana, 46350

Mishawaka, Indiana

Status

Address

Michiana Hematology-Oncology, PC - South Bend

Mishawaka, Indiana, 46545-1470

Saint Joseph Regional Medical Center, Mishawaka, Indiana

Status

Address

Saint Joseph Regional Medical Center

Mishawaka, Indiana, 46545-1470

Plymouth, Indiana

Status

Address

Michiana Hematology Oncology PC - Plymouth

Plymouth, Indiana, 46563

Reid Hospital & Health Care Services, Richmond, Indiana

Status

Address

Reid Hospital & Health Care Services

Richmond, Indiana, 47374

CCOP - Northern Indiana CR Consortium, South Bend, Indiana

Status

Address

CCOP - Northern Indiana CR Consortium

South Bend, Indiana, 46601

Memorial Hospital of South Bend, South Bend, Indiana

Status

Address

Memorial Hospital of South Bend

South Bend, Indiana, 46601

Westville, Indiana

Status

Address

Michiana Hematology Oncology PC - La Porte

Westville, Indiana, 46391

Cedar Rapids Oncology Associates, Cedar Rapids, Iowa

Status

Address

Cedar Rapids Oncology Associates

Cedar Rapids, Iowa, 52403

Cedar Rapids, Iowa

Status

Address

Mercy Regional Cancer Center at Mercy Medical Center

Cedar Rapids, Iowa, 52403

Clive, Iowa

Status

Address

Medical Oncology and Hematology Associates - West Des Moines

Clive, Iowa, 50325

Mercy Cancer Center - West Lakes, Clive, Iowa

Status

Address

Mercy Cancer Center - West Lakes

Clive, Iowa, 50325

Des Moines, Iowa

Status

Address

CCOP - Iowa Oncology Research Association

Des Moines, Iowa, 50309

Des Moines, Iowa

Status

Address

John Stoddard Cancer Center at Iowa Methodist Medical Center

Des Moines, Iowa, 50309

Des Moines, Iowa

Status

Address

Medical Oncology and Hematology Associates at John Stoddard Cancer Center

Des Moines, Iowa, 50309

Des Moines, Iowa

Status

Address

Medical Oncology and Hematology Associates at Mercy Cancer Center

Des Moines, Iowa, 50314

Des Moines, Iowa

Status

Address

Mercy Cancer Center at Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314

Des Moines, Iowa

Status

Address

John Stoddard Cancer Center at Iowa Lutheran Hospital

Des Moines, Iowa, 50316

Sioux City, Iowa

Status

Address

Siouxland Hematology-Oncology Associates, LLP

Sioux City, Iowa, 51101

Mercy Medical Center - Sioux City, Sioux City, Iowa

Status

Address

Mercy Medical Center - Sioux City

Sioux City, Iowa, 51102

St. Luke's Regional Medical Center, Sioux City, Iowa

Status

Address

St. Luke's Regional Medical Center

Sioux City, Iowa, 51104

Methodist West Hospital, West Des Moines, Iowa

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Address

Methodist West Hospital

West Des Moines, Iowa, 50266-7700

Cancer Center of Kansas, PA - Chanute, Chanute, Kansas

Status

Address

Cancer Center of Kansas, PA - Chanute

Chanute, Kansas, 66720

Cancer Center of Kansas, PA - Dodge City, Dodge City, Kansas

Status

Address

Cancer Center of Kansas, PA - Dodge City

Dodge City, Kansas, 67801

Cancer Center of Kansas, PA - El Dorado, El Dorado, Kansas

Status

Address

Cancer Center of Kansas, PA - El Dorado

El Dorado, Kansas, 67042

Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas

Status

Address

Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701

Cancer Center of Kansas-Independence, Independence, Kansas

Status

Address

Cancer Center of Kansas-Independence

Independence, Kansas, 67301

Cancer Center of Kansas, PA - Kingman, Kingman, Kansas

Status

Address

Cancer Center of Kansas, PA - Kingman

Kingman, Kansas, 67068

Lawrence Memorial Hospital, Lawrence, Kansas

Status

Address

Lawrence Memorial Hospital

Lawrence, Kansas, 66044

Cancer Center of Kansas, PA - Liberal, Liberal, Kansas

Status

Address

Cancer Center of Kansas, PA - Liberal

Liberal, Kansas, 67901

Cancer Center of Kansas, PA - Newton, Newton, Kansas

Status

Address

Cancer Center of Kansas, PA - Newton

Newton, Kansas, 67114

Cancer Center of Kansas, PA - Parsons, Parsons, Kansas

Status

Address

Cancer Center of Kansas, PA - Parsons

Parsons, Kansas, 67357

Cancer Center of Kansas, PA - Pratt, Pratt, Kansas

Status

Address

Cancer Center of Kansas, PA - Pratt

Pratt, Kansas, 67124

Cancer Center of Kansas, PA - Salina, Salina, Kansas

Status

Address

Cancer Center of Kansas, PA - Salina

Salina, Kansas, 67401

Cancer Center of Kansas, PA - Wellington, Wellington, Kansas

Status

Address

Cancer Center of Kansas, PA - Wellington

Wellington, Kansas, 67152

Wichita, Kansas

Status

Address

Associates in Womens Health, PA - North Review

Wichita, Kansas, 67208

Wichita, Kansas

Status

Address

Cancer Center of Kansas, PA - Medical Arts Tower

Wichita, Kansas, 67208

Cancer Center of Kansas, PA - Wichita, Wichita, Kansas

Status

Address

Cancer Center of Kansas, PA - Wichita

Wichita, Kansas, 67214

CCOP - Wichita, Wichita, Kansas

Status

Address

CCOP - Wichita

Wichita, Kansas, 67214

Wichita, Kansas

Status

Address

Via Christi Cancer Center at Via Christi Regional Medical Center

Wichita, Kansas, 67214

Wesley Medical Center, Wichita, Kansas

Status

Address

Wesley Medical Center

Wichita, Kansas, 67214

Cancer Center of Kansas, PA - Winfield, Winfield, Kansas

Status

Address

Cancer Center of Kansas, PA - Winfield

Winfield, Kansas, 67156

Adrian, Michigan

Status

Address

Hickman Cancer Center at Bixby Medical Center

Adrian, Michigan, 49221

Community Cancer Center of Monroe, Monroe, Michigan

Status

Address

Community Cancer Center of Monroe

Monroe, Michigan, 48162

Mercy Memorial Hospital - Monroe, Monroe, Michigan

Status

Address

Mercy Memorial Hospital - Monroe

Monroe, Michigan, 48162

Saint Joseph, Michigan

Status

Address

Lakeland Regional Cancer Care Center - St. Joseph

Saint Joseph, Michigan, 49085

Lakeside Cancer Specialists, PLLC, Saint Joseph, Michigan

Status

Address

Lakeside Cancer Specialists, PLLC

Saint Joseph, Michigan, 49085

MeritCare Bemidji, Bemidji, Minnesota

Status

Address

MeritCare Bemidji

Bemidji, Minnesota, 56601

Fairview Ridges Hospital, Burnsville, Minnesota

Status

Address

Fairview Ridges Hospital

Burnsville, Minnesota, 55337

Coon Rapids, Minnesota

Status

Address

Mercy and Unity Cancer Center at Mercy Hospital

Coon Rapids, Minnesota, 55433

Essentia Health - Duluth Clinic, Duluth, Minnesota

Status

Address

Essentia Health - Duluth Clinic

Duluth, Minnesota, 55805-1983

CCOP - Duluth, Duluth, Minnesota

Status

Address

CCOP - Duluth

Duluth, Minnesota, 55805

Miller - Dwan Medical Center, Duluth, Minnesota

Status

Address

Miller - Dwan Medical Center

Duluth, Minnesota, 55805

Fairview Southdale Hospital, Edina, Minnesota

Status

Address

Fairview Southdale Hospital

Edina, Minnesota, 55435

Fridley, Minnesota

Status

Address

Mercy and Unity Cancer Center at Unity Hospital

Fridley, Minnesota, 55432

Hutchinson Area Health Care, Hutchinson, Minnesota

Status

Address

Hutchinson Area Health Care

Hutchinson, Minnesota, 55350

Maplewood, Minnesota

Status

Address

HealthEast Cancer Care at St. John's Hospital

Maplewood, Minnesota, 55109

Minnesota Oncology - Maplewood, Maplewood, Minnesota

Status

Address

Minnesota Oncology - Maplewood

Maplewood, Minnesota, 55109

Minneapolis, Minnesota

Status

Address

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

Minneapolis, Minnesota, 55407

Minneapolis, Minnesota

Status

Address

Hennepin County Medical Center - Minneapolis

Minneapolis, Minnesota, 55415

Robbinsdale, Minnesota

Status

Address

Humphrey Cancer Center at North Memorial Outpatient Center

Robbinsdale, Minnesota, 55422-2900

Mayo Clinic Cancer Center, Rochester, Minnesota

Status

Address

Mayo Clinic Cancer Center

Rochester, Minnesota, 55905

CentraCare Clinic - River Campus, Saint Cloud, Minnesota

Status

Address

CentraCare Clinic - River Campus

Saint Cloud, Minnesota, 56303

Coborn Cancer Center, Saint Cloud, Minnesota

Status

Address

Coborn Cancer Center

Saint Cloud, Minnesota, 56303

CCOP - Metro-Minnesota, Saint Louis Park, Minnesota

Status

Address

CCOP - Metro-Minnesota

Saint Louis Park, Minnesota, 55416

Park Nicollet Cancer Center, Saint Louis Park, Minnesota

Status

Address

Park Nicollet Cancer Center

Saint Louis Park, Minnesota, 55416

Regions Hospital Cancer Care Center, Saint Paul, Minnesota

Status

Address

Regions Hospital Cancer Care Center

Saint Paul, Minnesota, 55101

United Hospital, Saint Paul, Minnesota

Status

Address

United Hospital

Saint Paul, Minnesota, 55102

Shakopee, Minnesota

Status

Address

St. Francis Cancer Center at St. Francis Medical Center

Shakopee, Minnesota, 55379

Lakeview Hospital, Stillwater, Minnesota

Status

Address

Lakeview Hospital

Stillwater, Minnesota, 55082

Ridgeview Medical Center, Waconia, Minnesota

Status

Address

Ridgeview Medical Center

Waconia, Minnesota, 55387

Willmar, Minnesota

Status

Address

Willmar Cancer Center at Rice Memorial Hospital

Willmar, Minnesota, 56201

Minnesota Oncology - Woodbury, Woodbury, Minnesota

Status

Address

Minnesota Oncology - Woodbury

Woodbury, Minnesota, 55125

Saint Louis, Missouri

Status

Address

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

Saint Louis, Missouri, 63110

CCOP - Montana Cancer Consortium, Billings, Montana

Status

Address

CCOP - Montana Cancer Consortium

Billings, Montana, 59101

Billings, Montana

Status

Address

St. Vincent Healthcare Cancer Care Services

Billings, Montana, 59101

Billings, Montana

Status

Address

Hematology-Oncology Centers of the Northern Rockies - Billings

Billings, Montana, 59102

Billings Clinic - Downtown, Billings, Montana

Status

Address

Billings Clinic - Downtown

Billings, Montana, 59107-7000

Bozeman Deaconess Cancer Center, Bozeman, Montana

Status

Address

Bozeman Deaconess Cancer Center

Bozeman, Montana, 59715

St. James Healthcare Cancer Care, Butte, Montana

Status

Address

St. James Healthcare Cancer Care

Butte, Montana, 59701

Benefis Sletten Cancer Institute, Great Falls, Montana

Status

Address

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405

St. Peter's Hospital, Helena, Montana

Status

Address

St. Peter's Hospital

Helena, Montana, 59601

Kalispell Regional Medical Center, Kalispell, Montana

Status

Address

Kalispell Regional Medical Center

Kalispell, Montana, 59901

Missoula, Montana

Status

Address

Montana Cancer Specialists at Montana Cancer Center

Missoula, Montana, 59807-7877

Missoula, Montana

Status

Address

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

Missoula, Montana, 59807

Concord, New Hampshire

Status

Address

New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care

Concord, New Hampshire, 03301

Hooksett, New Hampshire

Status

Address

New Hampshire Oncology - Hematology, PA - Hooksett

Hooksett, New Hampshire, 03106

Lakes Region General Hospital, Laconia, New Hampshire

Status

Address

Lakes Region General Hospital

Laconia, New Hampshire, 03246

University of New Mexico Cancer Center, Albuquerque, New Mexico

Status

Address

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87131-5636

East Syracuse, New York

Status

Address

CCOP - Hematology-Oncology Associates of Central New York

East Syracuse, New York, 13057

Mission Hospitals - Memorial Campus, Asheville, North Carolina

Status

Address

Mission Hospitals - Memorial Campus

Asheville, North Carolina, 28801

Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina

Status

Address

Wayne Memorial Hospital, Incorporated

Goldsboro, North Carolina, 27534

Bismarck, North Dakota

Status

Address

Medcenter One Hospital Cancer Care Center

Bismarck, North Dakota, 58501

Mid Dakota Clinic, PC, Bismarck, North Dakota

Status

Address

Mid Dakota Clinic, PC

Bismarck, North Dakota, 58501

St. Alexius Medical Center Cancer Center, Bismarck, North Dakota

Status

Address

St. Alexius Medical Center Cancer Center

Bismarck, North Dakota, 58502

MeritCare Broadway, Fargo, North Dakota

Status

Address

MeritCare Broadway

Fargo, North Dakota, 58102

Altru Cancer Center at Altru Hospital, Grand Forks, North Dakota

Status

Address

Altru Cancer Center at Altru Hospital

Grand Forks, North Dakota, 58201

Wood County Oncology Center, Bowling Green, Ohio

Status

Address

Wood County Oncology Center

Bowling Green, Ohio, 43402

Adena Regional Medical Center, Chillicothe, Ohio

Status

Address

Adena Regional Medical Center

Chillicothe, Ohio, 45601

Cincinnati, Ohio

Status

Address

Charles M. Barrett Cancer Center at University Hospital

Cincinnati, Ohio, 45267

Riverside Methodist Hospital Cancer Care, Columbus, Ohio

Status

Address

Riverside Methodist Hospital Cancer Care

Columbus, Ohio, 43214-3998

CCOP - Columbus, Columbus, Ohio

Status

Address

CCOP - Columbus

Columbus, Ohio, 43215

Grant Medical Center Cancer Care, Columbus, Ohio

Status

Address

Grant Medical Center Cancer Care

Columbus, Ohio, 43215

Mount Carmel Health - West Hospital, Columbus, Ohio

Status

Address

Mount Carmel Health - West Hospital

Columbus, Ohio, 43222

Doctors Hospital at Ohio Health, Columbus, Ohio

Status

Address

Doctors Hospital at Ohio Health

Columbus, Ohio, 43228

Grandview Hospital, Dayton, Ohio

Status

Address

Grandview Hospital

Dayton, Ohio, 45405

Good Samaritan Hospital, Dayton, Ohio

Status

Address

Good Samaritan Hospital

Dayton, Ohio, 45406

Dayton, Ohio

Status

Address

David L. Rike Cancer Center at Miami Valley Hospital

Dayton, Ohio, 45409

Samaritan North Cancer Care Center, Dayton, Ohio

Status

Address

Samaritan North Cancer Care Center

Dayton, Ohio, 45415

CCOP - Dayton, Dayton, Ohio

Status

Address

CCOP - Dayton

Dayton, Ohio, 45420

Grady Memorial Hospital, Delaware, Ohio

Status

Address

Grady Memorial Hospital

Delaware, Ohio, 43015

Community Cancer Center, Elyria, Ohio

Status

Address

Community Cancer Center

Elyria, Ohio, 44035

Hematology Oncology Center, Elyria, Ohio

Status

Address

Hematology Oncology Center

Elyria, Ohio, 44035

Blanchard Valley Medical Associates, Findlay, Ohio

Status

Address

Blanchard Valley Medical Associates

Findlay, Ohio, 45840

Middletown Regional Hospital, Franklin, Ohio

Status

Address

Middletown Regional Hospital

Franklin, Ohio, 45005-1066

Wayne Hospital, Greenville, Ohio

Status

Address

Wayne Hospital

Greenville, Ohio, 45331

Charles F. Kettering Memorial Hospital, Kettering, Ohio

Status

Address

Charles F. Kettering Memorial Hospital

Kettering, Ohio, 45429

Fairfield Medical Center, Lancaster, Ohio

Status

Address

Fairfield Medical Center

Lancaster, Ohio, 43130

Lima Memorial Hospital, Lima, Ohio

Status

Address

Lima Memorial Hospital

Lima, Ohio, 45804

Marietta, Ohio

Status

Address

Strecker Cancer Center at Marietta Memorial Hospital

Marietta, Ohio, 45750

Northwest Ohio Oncology Center, Maumee, Ohio

Status

Address

Northwest Ohio Oncology Center

Maumee, Ohio, 43537-1839

Knox Community Hospital, Mount Vernon, Ohio

Status

Address

Knox Community Hospital

Mount Vernon, Ohio, 43050

Newark, Ohio

Status

Address

Licking Memorial Cancer Care Program at Licking Memorial Hospital

Newark, Ohio, 43055

St. Charles Mercy Hospital, Oregon, Ohio

Status

Address

St. Charles Mercy Hospital

Oregon, Ohio, 43616

Toledo Clinic - Oregon, Oregon, Ohio

Status

Address

Toledo Clinic - Oregon

Oregon, Ohio, 43616

Portsmouth, Ohio

Status

Address

Southern Ohio Medical Center Cancer Center

Portsmouth, Ohio, 45662

Springfield, Ohio

Status

Address

Community Hospital of Springfield and Clark County

Springfield, Ohio, 45505

Flower Hospital Cancer Center, Sylvania, Ohio

Status

Address

Flower Hospital Cancer Center

Sylvania, Ohio, 43560

Mercy Hospital of Tiffin, Tiffin, Ohio

Status

Address

Mercy Hospital of Tiffin

Tiffin, Ohio, 44883

Toledo Hospital, Toledo, Ohio

Status

Address

Toledo Hospital

Toledo, Ohio, 43606

St. Vincent Mercy Medical Center, Toledo, Ohio

Status

Address

St. Vincent Mercy Medical Center

Toledo, Ohio, 43608

Medical University of Ohio Cancer Center, Toledo, Ohio

Status

Address

Medical University of Ohio Cancer Center

Toledo, Ohio, 43614

St. Anne Mercy Hospital, Toledo, Ohio

Status

Address

St. Anne Mercy Hospital

Toledo, Ohio, 43623

Toledo, Ohio

Status

Address

Toledo Clinic, Incorporated - Main Clinic

Toledo, Ohio, 43623

Troy, Ohio

Status

Address

UVMC Cancer Care Center at Upper Valley Medical Center

Troy, Ohio, 45373-1300

Fulton County Health Center, Wauseon, Ohio

Status

Address

Fulton County Health Center

Wauseon, Ohio, 43567

West Chester, Ohio

Status

Address

Precision Radiotherapy at University Pointe

West Chester, Ohio, 45069

Mount Carmel St. Ann's Cancer Center, Westerville, Ohio

Status

Address

Mount Carmel St. Ann's Cancer Center

Westerville, Ohio, 43081

Xenia, Ohio

Status

Address

Ruth G. McMillan Cancer Center at Greene Memorial Hospital

Xenia, Ohio, 45385

Genesis - Good Samaritan Hospital, Zanesville, Ohio

Status

Address

Genesis - Good Samaritan Hospital

Zanesville, Ohio, 43701

Tulsa, Oklahoma

Status

Address

Natalie Warren Bryant Cancer Center at St. Francis Hospital

Tulsa, Oklahoma, 74136

Allentown, Pennsylvania

Status

Address

Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

Allentown, Pennsylvania, 18105

Cancer Centers of the Carolinas - Easley, Easley, South Carolina

Status

Address

Cancer Centers of the Carolinas - Easley

Easley, South Carolina, 29640

Greenville, South Carolina

Status

Address

Cancer Centers of the Carolinas - Faris Road

Greenville, South Carolina, 29605

Greenville, South Carolina

Status

Address

Cancer Centers of the Carolinas - Grove Commons

Greenville, South Carolina, 29605

Greenville Hospital Cancer Center, Greenville, South Carolina

Status

Address

Greenville Hospital Cancer Center

Greenville, South Carolina, 29605

Greenville, South Carolina

Status

Address

Cancer Centers of the Carolinas - Eastside

Greenville, South Carolina, 29615

CCOP - Greenville, Greenville, South Carolina

Status

Address

CCOP - Greenville

Greenville, South Carolina, 29615

Greer, South Carolina

Status

Address

Cancer Centers of the Carolinas - Greer Medical Oncology

Greer, South Carolina, 29650

Greer, South Carolina

Status

Address

Cancer Centers of the Carolinas - Greer Radiation Oncology

Greer, South Carolina, 29650

Cancer Centers of the Carolinas - Seneca, Seneca, South Carolina

Status

Address

Cancer Centers of the Carolinas - Seneca

Seneca, South Carolina, 29672

Spartanburg, South Carolina

Status

Address

Cancer Centers of the Carolinas - Spartanburg

Spartanburg, South Carolina, 29307

Rapid City Regional Hospital, Rapid City, South Dakota

Status

Address

Rapid City Regional Hospital

Rapid City, South Dakota, 57701

Avera Cancer Institute, Sioux Falls, South Dakota

Status

Address

Avera Cancer Institute

Sioux Falls, South Dakota, 57105

Sioux Falls, South Dakota

Status

Address

Sanford Cancer Center at Sanford USD Medical Center

Sioux Falls, South Dakota, 57117-5039

Fredericksburg Oncology, Incorporated, Fredericksburg, Virginia

Status

Address

Fredericksburg Oncology, Incorporated

Fredericksburg, Virginia, 22401

Eau Claire, Wisconsin

Status

Address

Center for Cancer Treatment & Prevention at Sacred Heart Hospital

Eau Claire, Wisconsin, 54701

Eau Claire, Wisconsin

Status

Address

Marshfield Clinic Cancer Care at Regional Cancer Center

Eau Claire, Wisconsin, 54701

Fond Du Lac, Wisconsin

Status

Address

Central Wisconsin Cancer Program at Agnesian HealthCare

Fond Du Lac, Wisconsin, 54935

La Crosse, Wisconsin

Status

Address

Gundersen Lutheran Center for Cancer and Blood

La Crosse, Wisconsin, 54601

Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin

Status

Address

Marshfield Clinic - Marshfield Center

Marshfield, Wisconsin, 54449

Saint Joseph's Hospital, Marshfield, Wisconsin

Status

Address

Saint Joseph's Hospital

Marshfield, Wisconsin, 54449

Marshfield Clinic - Lakeland Center, Minocqua, Wisconsin

Status

Address

Marshfield Clinic - Lakeland Center

Minocqua, Wisconsin, 54548

Rhinelander, Wisconsin

Status

Address

Ministry Medical Group at Saint Mary's Hospital

Rhinelander, Wisconsin, 54501

Marshfield Clinic - Indianhead Center, Rice Lake, Wisconsin

Status

Address

Marshfield Clinic - Indianhead Center

Rice Lake, Wisconsin, 54868

Stevens Point, Wisconsin

Status

Address

Marshfield Clinic at Saint Michael's Hospital

Stevens Point, Wisconsin, 54481

Saint Michael's Hospital Cancer Center, Stevens Point, Wisconsin

Status

Address

Saint Michael's Hospital Cancer Center

Stevens Point, Wisconsin, 54481

Marshfield Clinic - Weston Center, Weston, Wisconsin

Status

Address

Marshfield Clinic - Weston Center

Weston, Wisconsin, 54476