Inclusion Criteria:
1. Patient must be greater than or equal to 3 years and less than or equal to 21 years
of age at the time of study enrollment.
2. Patients must have histologic verifications of a glioblastoma multiforme, anaplastic
astrocytoma, gliomatosis cerebri (WHO grade III or IV glioma with diffuse
parenchymal and/or leptomeningeal involvement), or gliosarcoma at the time of study
enrollment. Patients with newly diagnosed intrinsic brainstem gliomas, defined as
tumors with a pontine epicenter and diffuse rather than focal involvement of th
pons, with or without extension to adjacent medulla or midbrain, are eligible
without histologic confirmation. Patients with brainstem tumors that do not meet
these criteria or not considered to be typical intrinsic pontine gliomas will only
be eligible if the tumors are biopsied and proven to be a grade III or IV glioma
(anaplastic astrocytoma, glioblastoma multiforme, gliosarcoma).
3. Patients must have Karnofsky Performance Score (for patients greater than 16 years
of age) or Lansky Performance Score (for patients less than or equal to 16 years of
age) greater than or equal to 50% assessed within two weeks of study enrollment.
Patients who are unable to walk because of paralysis, but who are up in a
wheelchair, will be considered ambulatory for the purpose of assessing the
performance score.
4. Patients must not have received any prior chemotherapy, radiation therapy, biologic
therapy, or bone marrow transplant. Surgery and dexamethasone are permitted prior to
study entry. In patients who require anti-convulsant prior to study entry, it is
permissible to start VPA, but trough VPA concentration must be repeated within 48
hours of study entry.
5. Patients must have adequate bone marrow function defined as:
- - Hgb greater than or
equal to 8 gm/dL (transfusion independent) - Platelet count greater than or equal to
100,000/mm3 (transfusion independent) - Absolute neutrophil count (ANC) greater than
or equal to 1,000/ mm3.
6. Patients must have adequate liver function defined as:
- - Bilirubin (sum of conjugated + unconjugated) less than or equal to 1.5 times
institutional upper limit of normal (ULN) for age.
- - SGPT (ALT) less than or equal to 2.5 times institutional ULN for age.
- - Serum albumin greater than or equal to 2 g/dL.
7. Patients must have adequate renal function defined as:
- - Urine protein (albumin)/creatinine ratio of less than 1.0.
- - Creatinine clearance or radioisotope GFR greater than or equal to 70
ml/min/1.73m2 OR.
- - A serum creatinine based on age and gender as follows:
- 2 to less than 6 years of age: 0.8 mg/dL for male and female.
- - 6 to less than 10 year of age: 1.0 mg/dL for male and female.
- - 10 to less than 13 years of age: 1.2 mg/dL for male and female.
- - 13 to less than 16 years of age: 1.5 mg/dL for males and 1.4 for females.
- - Greater than or equal to 16 years of age: 1.7 mg/dL for males and 1.4
mg/dL for females.
Note: The threshold creatinine values in this table were derived from the Schwartz
formula for estimating GFR (Schwartz et al. J. Peds, 106:522, 1985) utilizing child
length and stature data published by the CDC.
8. Amylase and lipase less than or equal to 2 times institutional ULN for age.
9. Patients must not have a prolonged PT or PTT (greater than 1.2 times the
institutional upper limit of normal), and the INR must be less than 1.5.
10. MRI ECHO gradient sequences are required to evaluate for the presence or absence of
CNS hemorrhage. Patients with intra-tumoral and/or CNS hemorrhage are eligible for
study entry if they fulfill the following guidelines:
- - Patients with an asymptomatic intra-tumoral/intracranial hemorrhage measuring
less than 1 cm in the widest dimension on MRI at the time of diagnosis, after
surgery, and/or any time prior to study enrollment, are eligible; hemorrhage
must not have progressed on MRI prior to initiation of protocol therapy;
patients mut not have developed progressive symptoms thought to be related to
the intra-tumoral/intracranial hemorrhage prior to initiation of protocol
therapy.
- - Patients with a greater than 1 asymptomatic intra-tumoral/intracranial
hemorrhage but all measuring less than 1 cm in the widest dimension on MRI are
eligible if they fulfill the guidelines described above.
- - Patients with asymptomatic post-operative hemorrhage in and/or around the
surgical cavity are eligible for study entry if they otherwise fulfill the
guidelines described above.
- - Patients with an intra-tumoral hemorrhage greater than 1 cm at diagnosis but
who demonstrate minimal post-operative hemorrhage as described above after
tumor resection are eligible for study.
11. Patients must begin radiation therapy within 30 days of surgery or radiographic
diagnosis, whichever is the later date.
12. All patients and/or their legal guardians must sign a written informed consent.
Assent, when appropriate, will be obtained according to institutional guidelines.
Exclusion Criteria:
1. Females of reproductive potential must not be pregnant or lactating. Males or
females of reproductive potential may not participate unless they have agreed to use
an effective contraceptive method.
2. Patients with active or history of cardiac (CHF, myocardial infarction, myocarditis)
disease are excluded from this trial.
3. Patients receiving any of the following medications are not eligible for study
entry: a. Anti-cancer therapy or investigational agents b.Anti-coagulants (except
for heparin to maintain the patency of central venous catheters). c.Growth factors
for white blood cell, red blood cell or platelet support d.Aspirin (> 81 mg/day)
e.Non-steroidal anti-inflammatory drugs f.Clopidogrel (Plavix), Dypiramidole
(Persantine), or any other drug that inhibits platelet function g. Anti-convulsants:
patients on any anti-convulsant with the exception of VPA are eligible for study
entry. It is strongly recommended that a neurology consult be obtained to enable
discontinuation of all anti-convulsant other than VPA, whenever possible.
4. Patients who have an uncontrolled infection are not eligible.
5. Patients with inadequately controlled systemic hypertension (SBP and/or DBP greater
than 95th percentile for age and height)
6. Patients with a prior history of hypertensive crisis and/or hypertensive
encephalopathy. If a BP measurement prior to registration is greater than 95th percentile for age
and height, it must be rechecked and documented to be less than 95th percentile for
age and height prior to registration. If a patient falls between the height or
weight percentiles, site should average the value as appropriate. For patients
greater than or equal to 18 years, use adult normal ranges for blood pressure.
Patients with hypertension are eligible if their blood pressures become less than
95th percentile after anti hypertensive medications.
7. Prior Ischemic Events: Patients with a history of stroke, myocardial infarction, or
unstable angina within 6 months prior to registration are not eligible.
8. Vascular Disease: Patients with significant vascular disease (e.g., aortic aneurysm
requiring surgical repair or recent peripheral arterial thrombosis) within 6 months
prior to registration will not be eligible.
9. Patients with a history of hemoptysis, bleeding diathesis, known platelet disorder,
or coagulopathy are not eligible.
10. Patients with a history of abdominal fistula or GI perforation within 6 months prior
to registration are not eligible.
11. Patients with a known or suspected urea cycle or other metabolic disorder are not
eligible.
12. Patients with abnormality of the tibial metaphyseal plate on plain X-ray prior to
study entry are not eligible.
13. Patients with a history of a serious non-healing wound, ulcer, or bone fracture are
not eligible.
14. Patients with any clinically significant systemic illness, including serious
infection, pulmonary, hepatic, or other organ impairment, that would compromise
tolerance and/or timely completion of protocol therapy.
16. Patients who, in the opinion of the investigator, may not be able to comply with the
safety monitoring requirements and/or follow-up studies of this trial.
17. Patients with a known hypersensitivity to any component of bevacizumab are not
eligible for this trial.
