Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Study Purpose
This randomized phase II/III trial studies how well temozolomide and veliparib work compared to temozolomide alone in treating patients with newly diagnosed glioblastoma multiforme. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether temozolomide is more effective with or without veliparib in treating glioblastoma multiforme.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Histologic documentation: newly diagnosed World Health Organization (WHO) grade IV intracranial glioblastoma or gliosarcoma; GBM with oligodendroglial features are NOT PERMITTED in this study if they are 1p19q codeleted; sites submitting GBM with oligodendroglial features will be asked to provide results of 1p/19q codeletion status.
- - Sufficient tissue available for central pathology review and MGMT methylation status evaluation.
- - Patients who have had a local MGMT testing that is unmethylated are not allowed to participate.
- - Tumor MGMT promoter hypermethylation determined by central testing at MD Anderson.
- - Confirmation by central pathology review of WHO grade IV glioblastoma or gliosarcoma.
- - Absolute neutrophil count (ANC) >= 1500 cells/mm^3 (within 14 days prior to study registration) - Platelets >= 100,000 cells/mm^3 (within 14 days prior to study registration) - Creatinine =< 1.5 x upper limit of normal (ULN) (within 14 days prior to study registration) - Bilirubin =< 1.5 x ULN (within 14 days prior to study registration; unless patient has Gilbert's disease) - Alanine aminotransferase (ALT) =< 3 x ULN (within 14 days prior to study registration) - Aspartate aminotransferase (AST) =< 3 x ULN (within 14 days prior to study registration) - Eastern Cooperative Oncology Group (ECOG) performance status =< 2.
- - Measurable disease or non-measurable disease; extent of resection: patients with complete resection, partial resection, or biopsy are eligible.
- - Progression: patients deemed to have progressive disease based on clinical deterioration after chemoradiation or radiographic progression outside of the radiation field are not eligible; patients deemed to have pseudoprogression are eligible.
- - Prior treatment: - Must have completed standard radiotherapy and concomitant TMZ therapy as defined and determined by the study oncologist.
- - Besides concomitant TMZ with radiation, no other therapy (neo-adjuvant or adjuvant) can be given prior to study registration, including chemotherapy (also including Gliadel/carmustine [BCNU] wafers), biologics, immunotherapy, radiation therapy; the only exception is the Optune device (NovoTTF-100A), which may be started any time after end of radiation therapy up through the initiation of Cycle 1; intent to use Optune must be declared at registration for stratification.
- - No prior allogeneic bone marrow transplant or double umbilical cord blood transplantation.
- - Not pregnant and not nursing; females of childbearing potential must have negative urine or serum pregnancy test within 7 days of registration but before start of treatment; a female of childbearing potential is a sexually mature female who: - Has not undergone a hysterectomy or bilateral oophorectomy; or.
- - Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months) - Concomitant medications: patients receiving anticoagulation should be on stable dose 2 weeks prior to registration.
- - Comorbid conditions: patients are unable to participate due to the following: - Generalized or partial seizure disorder that is uncontrolled at the time of registration; the definition of controlled generalized seizures is patients must be on a stable dose of anti-seizure medication and without generalized seizures for at least 10 days prior to registration; the definition of controlled partial seizures is patients must be on a stable dose of anti-seizure medication for at least 10 days prior to registration; patients with occasional breakthrough partial seizures are allowed at treating physician's discretion.
- - Grade 3 or 4 thromboembolic disease within 6 months (mo) of registration.
- - Known history of prolonged QT syndrome.
- - No history of major surgery =< 14 days prior to registration.
- - Patients must have adequate organ and marrow function measured within 28 days prior to administration of ABT-888 as defined below: - >= 10.0 g/dL hemoglobin (Hb) with no blood transfusion in the past 28 days.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT02152982 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2/Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Jann N Sarkaria |
| Principal Investigator Affiliation | Alliance for Clinical Trials in Oncology |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Active, not recruiting |
| Countries | Puerto Rico, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Glioblastoma, Gliosarcoma |
PRIMARY OBJECTIVE:
- I. Test whether the experimental combination of ABT-888 (veliparib) combined with TMZ (temozolomide), compared to the control of placebo combined with TMZ, significantly extends overall survival in newly diagnosed glioblastoma multiforme (GBM) patients with tumor MGMT promoter hypermethylation.
- I. Test whether the experimental treatment significantly extends progression-free survival.
- II. Test whether the experimental treatment improves objective tumor response.
- III. Test whether the experimental treatment is associated with significantly greater rates of grade 3 or higher adverse events.
- I. Evaluate the utility of dynamic susceptibility contrast (DSC) and diffusion weighted imaging (DWI) magnetic resonance imaging (MRI) techniques in defining time to progression in the setting of a large multi-institutional clinical trial.
- II. Test the concordance between site-determined MGMT methylation status and central laboratory determination of MGMT status in cases with local testing.
- III. Evaluate whether genetic or epigenetic alterations in deoxyribonucleic acid (DNA) repair or replication genes are associated with overall survival, progression-free survival, and objective tumor response.
- IV. Test whether polymorphisms in MGMT, PARP1, or other DNA repair proteins, are associated with overall survival, progression-free survival, objective tumor response, or rates of grade 3 or higher adverse events.
Arms
Experimental: Arm I (temozolomide, veliparib)
Patients receive temozolomide PO QD on days 1-5 and veliparib PO BID on days 1-7. Treatment repeats every 28 days for 6 cycles in the absence of disease progression (confirmed progression) or unacceptable toxicity.
Placebo Comparator: Arm II (temozolomide, placebo)
Patients receive temozolomide as in Arm I and placebo PO BID on days 1-7. Treatment repeats every 28 days for 6 cycles in the absence of disease progression (confirmed progression) or unacceptable toxicity.
Interventions
Other: - Laboratory Biomarker Analysis
Correlative studies
Other: - Placebo Administration
Given PO
Other: - Quality-of-Life Assessment
Ancillary studies
Drug: - Temozolomide
Given PO
Drug: - Veliparib
Given PO
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
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Katmai Oncology Group
Anchorage, Alaska, 99508
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Address
Providence Alaska Medical Center
Anchorage, Alaska, 99508
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Address
Mayo Clinic in Arizona
Scottsdale, Arizona, 85259
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Address
Banner University Medical Center - Tucson
Tucson, Arizona, 85719
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Address
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Status
Address
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
Status
Address
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
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Address
Mills-Peninsula Medical Center
Burlingame, California, 94010
Status
Address
John Muir Medical Center-Concord
Concord, California, 94520
Status
Address
Kaiser Permanente-Fremont
Fremont, California, 94538
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Address
Fresno Cancer Center
Fresno, California, 93720
Status
Address
Kaiser Permanente-Fresno
Fresno, California, 93720
Status
Address
Saint Jude Medical Center
Fullerton, California, 92835
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Address
UC San Diego Moores Cancer Center
La Jolla, California, 92093
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Address
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
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Address
Los Angeles General Medical Center
Los Angeles, California, 90033
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Address
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
Status
Address
Kaiser Permanente-Modesto
Modesto, California, 95356
Status
Address
USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California, 92663
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Address
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
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Address
Kaiser Permanente-Oakland
Oakland, California, 94611
Status
Address
Saint Joseph Hospital - Orange
Orange, California, 92868
Status
Address
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
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Address
Kaiser Permanente-Redwood City
Redwood City, California, 94063
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Address
Kaiser Permanente-Richmond
Richmond, California, 94801
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Address
Rohnert Park Cancer Center
Rohnert Park, California, 94928
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Address
Kaiser Permanente-Roseville
Roseville, California, 95661
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Address
Sutter Roseville Medical Center
Roseville, California, 95661
Status
Address
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
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Address
Sutter Medical Center Sacramento
Sacramento, California, 95816
Status
Address
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
Status
Address
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
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Address
South Sacramento Cancer Center
Sacramento, California, 95823
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Address
Kaiser Permanente Sacramento Medical Center
Sacramento, California, 95825
Status
Address
Kaiser Permanente-San Francisco
San Francisco, California, 94115
Status
Address
UCSF Medical Center-Parnassus
San Francisco, California, 94143
Status
Address
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
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Address
Kaiser Permanente San Leandro
San Leandro, California, 94577
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Address
Kaiser Permanente-San Rafael
San Rafael, California, 94903
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Address
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
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Address
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California, 95065
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Address
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
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Address
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
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Address
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
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Address
Kaiser Permanente-Stockton
Stockton, California, 95210
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Address
Northbay Cancer Center
Vacaville, California, 95687
Status
Address
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
Status
Address
Kaiser Permanente-Vallejo
Vallejo, California, 94589
Status
Address
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
Status
Address
John Muir Medical Center-Walnut Creek
Walnut Creek, California, 94598
Status
Address
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
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Address
Boulder Community Hospital
Boulder, Colorado, 80301
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Address
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
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Address
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
Status
Address
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
Status
Address
Kaiser Permanente-Franklin
Denver, Colorado, 80205
Status
Address
Swedish Medical Center
Englewood, Colorado, 80113
Status
Address
Poudre Valley Hospital
Fort Collins, Colorado, 80524
Status
Address
Banner North Colorado Medical Center
Greeley, Colorado, 80631
Status
Address
Kaiser Permanente-Rock Creek
Lafayette, Colorado, 80026
Status
Address
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, 80120
Status
Address
Littleton Adventist Hospital
Littleton, Colorado, 80122
Status
Address
Kaiser Permanente-Lone Tree
Lone Tree, Colorado, 80124
Status
Address
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado, 80501
Status
Address
Banner McKee Medical Center
Loveland, Colorado, 80539
Status
Address
Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado, 80401
Status
Address
Hartford Hospital
Hartford, Connecticut, 06102
Status
Address
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105
Status
Address
Midstate Medical Center
Meriden, Connecticut, 06451
Status
Address
The Hospital of Central Connecticut
New Britain, Connecticut, 06050
Status
Address
Yale University
New Haven, Connecticut, 06520
Status
Address
Boca Raton Regional Hospital
Boca Raton, Florida, 33486
Status
Address
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442
Status
Address
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021
Status
Address
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980
Status
Address
Lakeland Regional Health Hollis Cancer Center
Lakeland, Florida, 33805
Status
Address
Mount Sinai Medical Center
Miami Beach, Florida, 33140
Status
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
Status
Address
AdventHealth Orlando
Orlando, Florida, 32803
Status
Address
Orlando Health Cancer Institute
Orlando, Florida, 32806
Status
Address
Memorial Hospital West
Pembroke Pines, Florida, 33028
Status
Address
Moffitt Cancer Center
Tampa, Florida, 33612
Status
Address
Piedmont Hospital
Atlanta, Georgia, 30309
Status
Address
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Status
Address
Northside Hospital
Atlanta, Georgia, 30342
Status
Address
John B Amos Cancer Center
Columbus, Georgia, 31904
Status
Address
Northeast Georgia Medical Center-Gainesville
Gainesville, Georgia, 30501
Status
Address
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
Status
Address
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813
Status
Address
Queen's Medical Center
Honolulu, Hawaii, 96813
Status
Address
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
Status
Address
Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii, 96817
Status
Address
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
Status
Address
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
Status
Address
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
Status
Address
OSF Saint Joseph Medical Center
Bloomington, Illinois, 61701
Status
Address
Northwestern University
Chicago, Illinois, 60611
Status
Address
Rush University Medical Center
Chicago, Illinois, 60612
Status
Address
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Status
Address
Decatur Memorial Hospital
Decatur, Illinois, 62526
Status
Address
Crossroads Cancer Center
Effingham, Illinois, 62401
Status
Address
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, 60201
Status
Address
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
Status
Address
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, 60026
Status
Address
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, 60035
Status
Address
Edward Hospital/Cancer Center
Naperville, Illinois, 60540
Status
Address
Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068
Status
Address
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Status
Address
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Status
Address
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
Status
Address
Edward Hospital/Cancer Center?Plainfield
Plainfield, Illinois, 60585
Status
Address
Central Illinois Hematology Oncology Center
Springfield, Illinois, 62702
Status
Address
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Status
Address
Springfield Memorial Hospital
Springfield, Illinois, 62781
Status
Address
Carle Cancer Center
Urbana, Illinois, 61801
Status
Address
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
Status
Address
Parkview Hospital Randallia
Fort Wayne, Indiana, 46805
Status
Address
Franciscan Health Indianapolis
Indianapolis, Indiana, 46237
Status
Address
Reid Health
Richmond, Indiana, 47374
Status
Address
Memorial Hospital of South Bend
South Bend, Indiana, 46601
Status
Address
Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa, 52402
Status
Address
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
Status
Address
Mission Cancer and Blood - West Des Moines
Clive, Iowa, 50325
Status
Address
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Status
Address
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Status
Address
Mission Cancer and Blood - Laurel
Des Moines, Iowa, 50314
Status
Address
Mercy Medical Center - North Iowa
Mason City, Iowa, 50401
Status
Address
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101
Status
Address
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
Status
Address
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720
Status
Address
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801
Status
Address
Cancer Center of Kansas - El Dorado
El Dorado, Kansas, 67042
Status
Address
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701
Status
Address
Cancer Center of Kansas-Independence
Independence, Kansas, 67301
Status
Address
Cancer Center of Kansas-Kingman
Kingman, Kansas, 67068
Status
Address
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
Status
Address
Cancer Center of Kansas-Liberal
Liberal, Kansas, 67905
Status
Address
Cancer Center of Kansas - McPherson
McPherson, Kansas, 67460
Status
Address
Cancer Center of Kansas - Newton
Newton, Kansas, 67114
Status
Address
Menorah Medical Center
Overland Park, Kansas, 66209
Status
Address
Cancer Center of Kansas - Parsons
Parsons, Kansas, 67357
Status
Address
Cancer Center of Kansas - Pratt
Pratt, Kansas, 67124
Status
Address
Cancer Center of Kansas - Salina
Salina, Kansas, 67401
Status
Address
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152
Status
Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208
Status
Address
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214
Status
Address
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67214
Status
Address
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156
Status
Address
Baptist Health Corbin
Corbin, Kentucky, 40701
Status
Address
Baptist Health Lexington
Lexington, Kentucky, 40503
Status
Address
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
Status
Address
Baptist Health Louisville
Louisville, Kentucky, 40207
Status
Address
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville, Kentucky, 42431
Status
Address
Baptist Health Paducah
Paducah, Kentucky, 42003
Status
Address
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809
Status
Address
The NeuroMedical Center-Clinic
Baton Rouge, Louisiana, 70810
Status
Address
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
Status
Address
Eastern Maine Medical Center
Bangor, Maine, 04401
Status
Address
Lafayette Family Cancer Center-EMMC
Brewer, Maine, 04412
Status
Address
Maine Center for Cancer Medicine-Scarborough
Scarborough, Maine, 04074
Status
Address
Maine Center for Cancer Medicine-Topsham
Topsham, Maine, 04086
Status
Address
Luminis Health Anne Arundel Medical Center
Annapolis, Maryland, 21401
Status
Address
Sinai Hospital of Baltimore
Baltimore, Maryland, 21215
Status
Address
Northwest Hospital Center
Randallstown, Maryland, 21133
Status
Address
TidalHealth Peninsula Regional
Salisbury, Maryland, 21801
Status
Address
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
Status
Address
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Status
Address
Simonds-Sinon Regional Cancer Center
Fitchburg, Massachusetts, 01420
Status
Address
Lowell General Hospital
Lowell, Massachusetts, 01854
Status
Address
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655
Status
Address
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
Status
Address
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109
Status
Address
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
Status
Address
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan, 49829
Status
Address
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
Status
Address
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
Status
Address
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
Status
Address
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
Status
Address
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912
Status
Address
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
Status
Address
Henry Ford Health Providence Novi Hospital
Novi, Michigan, 48374
Status
Address
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341
Status
Address
Corewell Health Reed City Hospital
Reed City, Michigan, 49677
Status
Address
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, 48073
Status
Address
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
Status
Address
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
Status
Address
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, 49085
Status
Address
Henry Ford Health Providence Southfield Hospital
Southfield, Michigan, 48075
Status
Address
Munson Medical Center
Traverse City, Michigan, 49684
Status
Address
University of Michigan Health - West
Wyoming, Michigan, 49519
Status
Address
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Status
Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
Status
Address
Essentia Health Cancer Center
Duluth, Minnesota, 55805
Status
Address
Saint Luke's Hospital of Duluth
Duluth, Minnesota, 55805
Status
Address
Fairview Southdale Hospital
Edina, Minnesota, 55435
Status
Address
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Status
Address
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
Status
Address
Health Partners Inc
Minneapolis, Minnesota, 55454
Status
Address
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
Status
Address
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Status
Address
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303
Status
Address
Regions Hospital
Saint Paul, Minnesota, 55101
Status
Address
United Hospital
Saint Paul, Minnesota, 55102
Status
Address
Rice Memorial Hospital
Willmar, Minnesota, 56201
Status
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Status
Address
University of Mississippi Medical Center
Jackson, Mississippi, 39216
Status
Address
Southeast Cancer Center
Cape Girardeau, Missouri, 63703
Status
Address
Saint Luke's Hospital
Chesterfield, Missouri, 63017
Status
Address
Centerpoint Medical Center LLC
Independence, Missouri, 64057
Status
Address
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111
Status
Address
Saint Luke's East - Lee's Summit
Lee's Summit, Missouri, 64086
Status
Address
Washington University School of Medicine
Saint Louis, Missouri, 63110
Status
Address
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
Status
Address
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
Status
Address
Mercy Hospital Springfield
Springfield, Missouri, 65804
Status
Address
CoxHealth South Hospital
Springfield, Missouri, 65807
Status
Address
Billings Clinic Cancer Center
Billings, Montana, 59101
Status
Address
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
Status
Address
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
Status
Address
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803
Status
Address
CHI Health Good Samaritan
Kearney, Nebraska, 68847
Status
Address
Faith Regional Health Services Carson Cancer Center
Norfolk, Nebraska, 68701
Status
Address
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
Status
Address
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Status
Address
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Status
Address
Nebraska Cancer Specialists - Omaha
Omaha, Nebraska, 68124
Status
Address
Creighton University Medical Center
Omaha, Nebraska, 68131
Status
Address
University of Nebraska Medical Center
Omaha, Nebraska, 68198
Status
Address
Renown Regional Medical Center
Reno, Nevada, 89502
Status
Address
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire, 03301
Status
Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Status
Address
Solinsky Center for Cancer Care
Manchester, New Hampshire, 03103
Status
Address
Portsmouth Regional Hospital
Portsmouth, New Hampshire, 03802
Status
Address
John F Kennedy Medical Center
Edison, New Jersey, 08818
Status
Address
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Status
Address
Saint Barnabas Medical Center
Livingston, New Jersey, 07039
Status
Address
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903
Status
Address
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
Status
Address
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey, 07652
Status
Address
Valley Health System Ridgewood Campus
Ridgewood, New Jersey, 07450
Status
Address
Overlook Hospital
Summit, New Jersey, 07902
Status
Address
Valley Health System-Hematology/Oncology
Westwood, New Jersey, 07675
Status
Address
Montefiore Medical Center - Moses Campus
Bronx, New York, 10467
Status
Address
Roswell Park Cancer Institute
Buffalo, New York, 14263
Status
Address
Mary Imogene Bassett Hospital
Cooperstown, New York, 13326
Status
Address
Mount Sinai Hospital
New York, New York, 10029
Status
Address
University of Rochester
Rochester, New York, 14642
Status
Address
State University of New York Upstate Medical University
Syracuse, New York, 13210
Status
Address
Mission Hospital
Asheville, North Carolina, 28801
Status
Address
East Carolina University
Greenville, North Carolina, 27834
Status
Address
ECU Health Oncology Kinston
Kinston, North Carolina, 28501
Status
Address
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Status
Address
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Status
Address
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Status
Address
Altru Cancer Center
Grand Forks, North Dakota, 58201
Status
Address
Cleveland Clinic Akron General
Akron, Ohio, 44307
Status
Address
Cleveland Clinic Mercy Hospital
Canton, Ohio, 44708
Status
Address
Adena Regional Medical Center
Chillicothe, Ohio, 45601
Status
Address
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219
Status
Address
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Status
Address
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Status
Address
Mount Carmel East Hospital
Columbus, Ohio, 43213
Status
Address
Riverside Methodist Hospital
Columbus, Ohio, 43214
Status
Address
Grant Medical Center
Columbus, Ohio, 43215
Status
Address
Good Samaritan Hospital - Dayton
Dayton, Ohio, 45406
Status
Address
Miami Valley Hospital
Dayton, Ohio, 45409
Status
Address
Dayton Physician LLC - Englewood
Dayton, Ohio, 45415
Status
Address
Miami Valley Hospital North
Dayton, Ohio, 45415
Status
Address
Armes Family Cancer Center
Findlay, Ohio, 45840
Status
Address
Blanchard Valley Hospital
Findlay, Ohio, 45840
Status
Address
Orion Cancer Care
Findlay, Ohio, 45840
Status
Address
Wayne Hospital
Greenville, Ohio, 45331
Status
Address
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, 43537
Status
Address
Saint Charles Hospital
Oregon, Ohio, 43616
Status
Address
Mercy Health - Perrysburg Hospital
Perrysburg, Ohio, 43551
Status
Address
ProMedica Flower Hospital
Sylvania, Ohio, 43560
Status
Address
Mercy Health - Saint Anne Hospital
Toledo, Ohio, 43623
Status
Address
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
Status
Address
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Status
Address
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma, 74146
Status
Address
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, 97210
Status
Address
Providence Portland Medical Center
Portland, Oregon, 97213
Status
Address
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
Status
Address
Kaiser Permanente Northwest
Portland, Oregon, 97227
Status
Address
Jefferson Abington Hospital
Abington, Pennsylvania, 19001
Status
Address
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Status
Address
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Status
Address
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania, 17109
Status
Address
Lancaster General Hospital
Lancaster, Pennsylvania, 17602
Status
Address
Paoli Memorial Hospital
Paoli, Pennsylvania, 19301
Status
Address
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Status
Address
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232
Status
Address
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania, 18840
Status
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Status
Address
UPMC Susquehanna
Williamsport, Pennsylvania, 17701
Status
Address
Lankenau Medical Center
Wynnewood, Pennsylvania, 19096
Status
Address
Rhode Island Hospital
Providence, Rhode Island, 02903
Status
Address
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
Status
Address
Roper Hospital
Charleston, South Carolina, 29401
Status
Address
Charleston Oncology - Roper
Charleston, South Carolina, 29403
Status
Address
Lowcountry Hematology Oncology PA-North Charleston
Charleston, South Carolina, 29406
Status
Address
Bon Secours Saint Francis Hospital
Charleston, South Carolina, 29414
Status
Address
Charleston Oncology - Saint Francis
Charleston, South Carolina, 29414
Status
Address
Lowcountry Hematology Oncology PA-West Ashley
Charleston, South Carolina, 29414
Status
Address
Medical University of South Carolina
Charleston, South Carolina, 29425
Status
Address
Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640
Status
Address
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341
Status
Address
Greenville Health System Cancer Institute-Andrews
Greenville, South Carolina, 29601
Status
Address
Saint Francis Hospital
Greenville, South Carolina, 29601
Status
Address
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605
Status
Address
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
Status
Address
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605
Status
Address
Saint Francis Cancer Center
Greenville, South Carolina, 29607
Status
Address
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
Status
Address
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
Status
Address
Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651
Status
Address
Lowcountry Hematology Oncology PA-Mount Pleasant
Mount Pleasant, South Carolina, 29464
Status
Address
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
Status
Address
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
Status
Address
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota, 57401
Status
Address
Rapid City Regional Hospital
Rapid City, South Dakota, 57701
Status
Address
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Status
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Status
Address
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee, 37660
Status
Address
University of Tennessee - Knoxville
Knoxville, Tennessee, 37920
Status
Address
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
Status
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
Status
Address
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234
Status
Address
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
Status
Address
Ben Taub General Hospital
Houston, Texas, 77030
Status
Address
M D Anderson Cancer Center
Houston, Texas, 77030
Status
Address
Memorial Hermann Texas Medical Center
Houston, Texas, 77030
Status
Address
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
Status
Address
University of Vermont and State Agricultural College
Burlington, Vermont, 05405
Status
Address
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
Status
Address
Danville Regional Medical Center
Danville, Virginia, 24541
Status
Address
Inova Fairfax Hospital
Falls Church, Virginia, 22042
Status
Address
MultiCare Auburn Medical Center
Auburn, Washington, 98001
Status
Address
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
Status
Address
Highline Medical Center-Main Campus
Burien, Washington, 98166
Status
Address
MultiCare Gig Harbor Medical Park
Gig Harbor, Washington, 98335
Status
Address
Jefferson Healthcare
Port Townsend, Washington, 98368
Status
Address
MultiCare Good Samaritan Hospital
Puyallup, Washington, 98372
Status
Address
Virginia Mason Medical Center
Seattle, Washington, 98101
Status
Address
Franciscan Research Center-Northwest Medical Plaza
Tacoma, Washington, 98405
Status
Address
MultiCare Tacoma General Hospital
Tacoma, Washington, 98405
Status
Address
Northwest Medical Specialties PLLC
Tacoma, Washington, 98405
Status
Address
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
Status
Address
Edwards Comprehensive Cancer Center
Huntington, West Virginia, 25701
Status
Address
West Virginia University Healthcare
Morgantown, West Virginia, 26506
Status
Address
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105
Status
Address
HSHS Sacred Heart Hospital
Eau Claire, Wisconsin, 54701
Status
Address
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire, Wisconsin, 54701
Status
Address
Aurora Health Center-Fond du Lac
Fond Du Lac, Wisconsin, 54937
Status
Address
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022
Status
Address
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
Status
Address
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
Status
Address
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
Status
Address
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
Status
Address
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin, 53548
Status
Address
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
Status
Address
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
Status
Address
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Status
Address
Marshfield Medical Center
Marshfield, Wisconsin, 54449
Status
Address
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53209
Status
Address
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
Status
Address
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Status
Address
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233
Status
Address
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
Status
Address
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
Status
Address
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Status
Address
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, 54154
Status
Address
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904
Status
Address
Aurora Cancer Care-Racine
Racine, Wisconsin, 53406
Status
Address
Lakeview Medical Center-Marshfield Clinic
Rice Lake, Wisconsin, 54868
Status
Address
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
Status
Address
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
Status
Address
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
Status
Address
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
Status
Address
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
Status
Address
Aurora Cancer Care-Waukesha
Waukesha, Wisconsin, 53188
Status
Address
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
Status
Address
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
Status
Address
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226
Status
Address
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227
Status
Address
Diagnostic and Treatment Center
Weston, Wisconsin, 54476
Status
Address
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
International Sites
Status
Address
Fundacion De Investigacion de Diego
San Juan, , 00927
