Clinical Trial Finder

Inclusion Criteria:

• - Newly diagnosed and histologically confirmed glioblastoma.

• - Recursive partitioning analysis (RPA) class III or IV.

• - Age > or = 18 years and < 75 years of age.

• - Life expectancy > or = 6 months.

• - Patient must have at least 1 formalin fixed paraffin embedded tumor tissue block representative of glioblastoma available for pathology central review and biomarker exploration.

• - Adequate hematologic (absolute neutrophil count (ANC) > or = 1.5 x 109/L, platelet count > or = 100 x 109/L, hemoglobin > or = 10 g/dL ), renal (creatinine > or = 1.25 x ULN ), and hepatic function (total bilirubin < or = 1.5 x ULN, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < or = 2.5 x ULN) - Patients who were receiving corticosteroids had to receive a stable or decreasing dose for at least 14 days before enrollment.

• - Patients must be able to swallow and retain oral medication.

• - Women must have a negative serum pregnancy test less than 7 days prior to the first dose of study drug.

• - Both men and women of reproductive potential agree to use approved contraception during the study and for 6 months after discontinuation of study treatment.

• - Willing and able to comply with the protocol as judged by the investigator.

• - Patients must provide written consent.

Exclusion Criteria:

• - Any prior chemotherapy (including carmustine-containing wafers) or immunotherapy (including vaccine therapy ) - Any prior radiotherapy to the brain.

• - Any contraindication to temozolomide listed in the local label.

• - Have had, in the judgment of the investigator, a major bowel resection that would alter oral drug absorption.

• - Have a diagnosis of inflammatory bowel disease (Crohn's disease or ulcerative colitis) - Have previously completed or withdrawn from this study or any other study investigating LY2228820.

• - Are receiving, in the judgment of the investigator, concurrent administration of immunosuppressive therapy.

• - Diarrhea of any cause CTCAE > or = grade 2.

• - Current or recent (within 30 days of enrollment) treatment with another investigational drug or participation in another investigational study.

• - History of other malignancy within 5 years prior enrollment except for basal cell carcinoma of the skin or carcinoma in situ of the cervix.

• - Pregnant or nursing (lactating) woman, or fertile women unwilling or unable to use effective means of contraception.

- Psychiatric illness / social situations that would compromise patient safety or limit compliance with study requirements including maintenance of a compliance / pill diary

Arms

Experimental: LY2228820 + TMZ + Radiotherapy

addition of LY2228820 to standard radiotherapy and concomitant treatment by temozolomide (TMZ). LY2228820 will be administered orally for two 28 day cycles, from one week before the beginning of radiotherapy, and during standard chemoradiotherapy. Three dose levels of LY2228820 will be tested. After a 4 week break after concomitant treatment, patient were then received up to 6 cycles of adjuvant TMZ according to the standard 5-day schedule every 28 days .

Interventions

Drug: - LY2228820

Drug: - Temozolomide

Radiation: - radiotherapy