A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification
Study Purpose
This study seeks to determine whether the addition of ABT-414 to concomitant radiotherapy and temozolomide (TMZ) followed by combination of ABT-414 with adjuvant TMZ prolongs overall survival (OS) among participants with newly diagnosed glioblastoma (GBM) with epidermal growth factor receptor (EGFR) amplification. In addition, there is a Phase 1, open-label, multicenter sub-study to assess the pharmacokinetics, safety and tolerability of ABT-414 in participants with newly diagnosed EGFR-amplified GBM who have mild or moderate hepatic impairment.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years - 99 Years |
| Gender | All |
Inclusion Criteria:
- - Must have a clinical diagnosis of glioblastoma (GBM).
- - Must have a confirmed epidermal growth factor receptor amplification in tumor tissue.
- - Must have a Karnofsky Performance Status (KPS) >= 70 at assessment <= 14 days prior to randomization (N/A to the sub-study).
- - Must have recovered from effects of surgery, postoperative infection and other complications of surgery.
- - Must have adequate bone marrow, renal, and hepatic function (For the sub-study, the participant must have adequate bone marrow and renal function and have mild-to-moderate hepatic impairment).
Exclusion Criteria:
- - Multifocal, recurrent or metastatic GBM or gliomatosis cerebri (For the sub-study, the participant can have multifocal GBM and glimatosis cerebri but can't have recurrent or metastatic GBM).
- - Prior chemo therapy or radiosensitizer for head and neck cancer.
- - Prior radiotherapy to the head or neck in overlap of radiation fields.
- - Prior therapy for glioblastoma or other invasive malignancy.
- - Prior, concomitant or planned treatment with Novo Tumor Treatment Fields (Novo-TTF), EGFR-targeted therapy, bevacizumab, Gliadel wafers or other intratumoral or intracavity anti-neoplastic therapy.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT02573324 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
AbbVie |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
ABBVIE INC. |
| Principal Investigator Affiliation | AbbVie |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry, Other |
| Overall Status | Completed |
| Countries | Argentina, Australia, Austria, Belgium, Brazil, Canada, China, Colombia, Czechia, France, Germany, Hong Kong, Ireland, Israel, Italy, Korea, Republic of, Mexico, Netherlands, New Zealand, Portugal, Russian Federation, Singapore, South Africa, Spain, Switzerland, Taiwan, United Kingdom, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Glioblastoma, Gliosarcoma |
| Study Website: | View Trial Website |
Arms
Experimental: Depatuxizumab Mafodotin, Radiation and Temozolomide (TMZ)
Depatuxizumab mafodotin is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase.
Placebo Comparator: Placebo, Radiation and TMZ
Placebo is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Placebo is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase.
Experimental: Open-Label Sub-Study: Depatuxizumab Mafodotin, Radiation and TMZ
Depatuxizumab mafodotin is given to participants with hepatic impairment on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase.
Interventions
Drug: - Temozolomide
Oral Capsule
Drug: - Depatuxizumab mafodotin
Intravenous (IV) Infusion
Radiation: - Radiation
Drug: - Placebo for ABT-414
IV Infusion (IV)
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
St. Josephs Hospital and Med Center /ID# 144149
Phoenix, Arizona, 85013
Status
Address
Highlands Oncology Group, PA /ID# 142050
Springdale, Arkansas, 72762
Status
Address
University of Southern California /ID# 147543
Los Angeles, California, 90033
Status
Address
University of California, Los Angeles /ID# 149239
Los Angeles, California, 90095
Status
Address
Sharp Memorial Hospital /ID# 148193
San Diego, California, 92123
Status
Address
Univ California, San Francisco /ID# 145889
San Francisco, California, 94143-2204
Status
Address
Duplicate_St. John's Health Center /ID# 148192
Santa Monica, California, 90404
Status
Address
Cedars-Sinai Medical Center-West Hollywood /ID# 148472
West Hollywood, California, 90048
Status
Address
Univ of Colorado Cancer Center /ID# 148194
Aurora, Colorado, 80045
Status
Address
Associated Neurologists of Sou /ID# 147701
Fairfield, Connecticut, 06824
Status
Address
Yale University /ID# 144170
New Haven, Connecticut, 06510
Status
Address
Christiana Care Health Service /ID# 144127
Newark, Delaware, 19713
Status
Address
Boca Raton Regional Hospital /ID# 163659
Boca Raton, Florida, 33486
Status
Address
Holy Cross Hospital /ID# 156764
Fort Lauderdale, Florida, 33308
Status
Address
Baptist Hospital Miami /ID# 152451
Miami, Florida, 33176
Status
Address
Advent Health /ID# 144128
Orlando, Florida, 32803
Status
Address
Moffitt Cancer Center /ID# 144130
Tampa, Florida, 33612-9416
Status
Address
Piedmont Hospital /ID# 145892
Atlanta, Georgia, 30309
Status
Address
Emory Midtown Infectious Disease Clinic /ID# 144015
Atlanta, Georgia, 30322
Status
Address
Northwestern University Feinberg School of Medicine /ID# 147895
Chicago, Illinois, 60611-2927
Status
Address
The University of Chicago Medical Center /ID# 144158
Chicago, Illinois, 60637-1443
Status
Address
NorthShore University HealthSystem /ID# 144017
Evanston, Illinois, 60201
Status
Address
Northwestern Medicine Cancer Center - Warrenville /ID# 148476
Warrenville, Illinois, 60555
Status
Address
Parkview Research Ctr, Hosp /ID# 144150
Fort Wayne, Indiana, 46805
Status
Address
Univ Kansas Cancer Ctr - Overl /ID# 145895
Westwood, Kansas, 66205-2003
Status
Address
Maine Medical Partners Neurolo /ID# 160864
Scarborough, Maine, 04074
Status
Address
Tufts Medical Center /ID# 145897
Boston, Massachusetts, 02111-1552
Status
Address
Massachusetts General Hospital /ID# 144145
Boston, Massachusetts, 02114
Status
Address
Dana-Farber Cancer Institute /ID# 148475
Boston, Massachusetts, 02215
Status
Address
Wayne State University /ID# 145890
Detroit, Michigan, 48201-2013
Status
Address
Henry Ford Health System /ID# 145896
Detroit, Michigan, 48202
Status
Address
Duplicate_St. Joseph Mercy Hospital /ID# 144143
Ypsilanti, Michigan, 48197
Status
Address
Mmcorc /Id# 144146
Saint Louis Park, Minnesota, 55416
Status
Address
Washington University-School of Medicine /ID# 144174
Saint Louis, Missouri, 63110
Status
Address
Nebraska Methodist Hospital /ID# 144140
Omaha, Nebraska, 68114
Status
Address
University of Nebraska Medical Center /ID# 145899
Omaha, Nebraska, 68198
Status
Address
MD Anderson Cancer Center at Cooper - Camden /ID# 145891
Camden, New Jersey, 08103
Status
Address
Rutgers Cancer Institute of New Jersey /ID# 148190
New Brunswick, New Jersey, 08901
Status
Address
Columbia University Medical Center /ID# 144020
New York, New York, 10032-3729
Status
Address
University of Rochester Medical Center /ID# 144166
Rochester, New York, 14642
Status
Address
Levine Cancer Ins, Carolina Me /ID# 144124
Charlotte, North Carolina, 28204
Status
Address
University of Cincinnati /ID# 144164
Cincinnati, Ohio, 45267-0585
Status
Address
Duplicate_Univ Hosp Cleveland /ID# 144153
Cleveland, Ohio, 44106
Status
Address
Cleveland Clinic Main Campus /ID# 144023
Cleveland, Ohio, 44195
Status
Address
The Ohio State University /ID# 144016
Columbus, Ohio, 43210
Status
Address
University of Toledo /ID# 156763
Toledo, Ohio, 43614
Status
Address
Univ Oklahoma HSC /ID# 144161
Oklahoma City, Oklahoma, 73104
Status
Address
St. Luke's Hospital /ID# 148191
Bethlehem, Pennsylvania, 18017
Status
Address
Penn State University and Milton S. Hershey Medical Center /ID# 147525
Hershey, Pennsylvania, 17033
Status
Address
University of Pennsylvania /ID# 157623
Philadelphia, Pennsylvania, 19104-5502
Status
Address
Thomas Jefferson University /ID# 144191
Philadelphia, Pennsylvania, 19107-4414
Status
Address
Fox Chase Cancer Center /ID# 145893
Philadelphia, Pennsylvania, 19111
Status
Address
Allegheny General Hospital /ID# 144126
Pittsburgh, Pennsylvania, 15212
Status
Address
University of Pennsylvania Medical Center - Shadyside /ID# 144159
Pittsburgh, Pennsylvania, 15232
Status
Address
Medical University of South Carolina /ID# 144141
Charleston, South Carolina, 29425
Status
Address
Austin Cancer Centers /ID# 151061
Austin, Texas, 78758
Status
Address
Baylor Sammons Cancer Center /ID# 155542
Dallas, Texas, 75246
Status
Address
The University of Texas Health Science Center at Houston /ID# 144013
Houston, Texas, 77030
Status
Address
University of Texas MD Anderson Cancer Center /ID# 144018
Houston, Texas, 77030
Status
Address
Duplicate_Scott and White Medical Center /ID# 160743
Temple, Texas, 76508
Status
Address
Intermountain Medical Center /ID# 144142
Murray, Utah, 84107-5701
Status
Address
University of Utah /ID# 144160
Salt Lake City, Utah, 84112-5500
Status
Address
Inova Health System /ID# 152956
Falls Church, Virginia, 22042
Status
Address
Virginia Commonwealth University Medical Center Main Hospital /ID# 149014
Richmond, Virginia, 23219
Status
Address
Virginia Mason Medical Center /ID# 144022
Seattle, Washington, 98101
Status
Address
University of Washington /ID# 144162
Seattle, Washington, 98109
Status
Address
Univ of Wisconsin Hosp/Clinics /ID# 144167
Madison, Wisconsin, 53792-0001
Status
Address
Froedtert Memorial Lutheran Hospital /ID# 144139
Milwaukee, Wisconsin, 53226-3522
International Sites
Status
Address
Sanatorio Parque /ID# 142825
Rosario, Santa Fe, 2000
Status
Address
Duplicate_Instituto Med Alex Flem /ID# 142884
Buenos Aires, , 1426
Status
Address
Liverpool Hospital /ID# 144392
Liverpool, New South Wales, 2170
Status
Address
Duplicate_The Prince of Wales Hospital /ID# 144882
Randwick, New South Wales, 2031
Status
Address
Royal North Shore Hospital /ID# 143870
St Leonards, New South Wales, 2065
Status
Address
Calvary Mater Newcastle /ID# 143860
Waratah, New South Wales, 2298
Status
Address
Southern Medical Day Care Centre /ID# 143868
Wollongong, New South Wales, 2500
Status
Address
Princess Alexandra Hospital /ID# 143857
Woolloongabba, Queensland, 4102
Status
Address
Royal Adelaide Hospital /ID# 143867
Adelaide, South Australia, 5000
Status
Address
Calvary North Adelaide Hospita /ID# 143866
Adelaide, South Australia, 5006
Status
Address
St Vincent's Hospital Melbourne /ID# 143858
Fitzroy Melbourne, Victoria, 3065
Status
Address
Duplicate_Austin Hospital /ID# 143859
Heidelberg, Victoria, 3084
Status
Address
St John Of God Subiaco Hospital /ID# 143869
Subiaco, Western Australia, 6008
Status
Address
Medizinische Universitaet Graz /ID# 141982
Graz, Steiermark, 8036
Status
Address
Medizinische Universitaet Wien /ID# 141981
Vienna, Wien, 1090
Status
Address
Duplicate_Medizinische Universitat Innsbruck,Universitatsklinik fur Innere Mediz /ID# 141984
Innsbruck, , 6020
Status
Address
Kepler Universitätsklinikum GmbH - Neuromed Campus /ID# 141983
Linz, , 4020
Status
Address
UCL Saint-Luc /ID# 141648
Woluwe-Saint-Lambert, Bruxelles-Capitale, 1200
Status
Address
Grand Hopital de Charleroi /ID# 141645
Charleroi, Hainaut, 6000
Status
Address
UZ Gent /ID# 141647
Gent, Oost-Vlaanderen, 9000
Status
Address
Universitair Ziekenhuis Leuven /ID# 143872
Leuven, Vlaams-Brabant, 3000
Status
Address
Duplicate_Centre Hospitalier Jolimont /ID# 143873
La Louvière, , 7100
Status
Address
CHU de Liege /ID# 162860
Liege, , 4000
Status
Address
Duplicate_UCL Mont Godinne /ID# 141644
Yvoir, , 5530
Status
Address
Liga Norte Riograndense Contra o Câncer /ID# 143878
Natal, Rio Grande Do Norte, 59075-740
Status
Address
Hospital Sao Lucas da PUCRS /ID# 143879
Porto Alegre, Rio Grande Do Sul, 90610-000
Status
Address
Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 143876
Barretos, Sao Paulo, 14784-400
Status
Address
Instituto do Câncer do Estado de São Paulo - ICESP /ID# 144031
São Paulo, Sao Paulo, 01246-000
Status
Address
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) /ID# 143877
Rio de Janeiro, , 20231-050
Status
Address
Duplicate_Cancer Care Manitoba /ID# 149253
Winnipeg, Manitoba, R3E 0V9
Status
Address
QE II Health Sciences Centre /ID# 151600
Halifax, Nova Scotia, B3H 1V7
Status
Address
Juravinski Cancer Centre /ID# 152117
Hamilton, Ontario, L8V 1C3
Status
Address
Victoria Hospital /ID# 144184
London, Ontario, N6A 4L6
Status
Address
Ottawa Hospital Research Institute /ID# 150120
Ottawa, Ontario, K1H 8L6
Status
Address
Princess Margaret Cancer Centre /ID# 166277
Toronto, Ontario, M5G 2M9
Status
Address
Duplicate_Hospital Maisonneuve-Rosemont /ID# 149315
Montreal, Quebec, H1T 2M4
Status
Address
Duplicate_Jewish General Hospital /ID# 144029
Montreal, Quebec, H3T 1E2
Status
Address
Royal Victoria Hospital / McGill University Health Centre /ID# 144187
Montreal, Quebec, H4A 3J1
Status
Address
CHUM - Notre-Dame Hospital /ID# 144027
Montréal, Quebec, H2X 0A9
Status
Address
CHU de Quebec-Universite Laval /ID# 144189
Quebec City, Quebec, G1R 2J6
Status
Address
CHUS - Hopital Fleurimont /ID# 149771
Sherbrooke, Quebec, J1H 5N4
Status
Address
Anhui Provincial Hospital /ID# 166320
Hefei, Anhui, 230001
Status
Address
SanboBrain Hospital Capital Medical University /ID# 166422
Beijing, Beijing, 100042
Status
Address
Peking Union Medical College Hospital /ID# 157430
Beijing, Beijing, 100730
Status
Address
Sun Yat-Sen University Cancer Center /ID# 143919
Guangzhou, Guangdong, 510060
Status
Address
Tongji Hospital Tongji Medical College of HUST /ID# 163820
Wuhan, Hubei, 430030
Status
Address
Duplicate_Xiangya Hospital Central South University /ID# 166791
Changsha, Hunan, 410008
Status
Address
The First Affiliated Hospital of Soochow University /ID# 165596
Suzhou, Jiangsu, 215006
Status
Address
Duplicate_Tangdu Hospital /ID# 143920
Xi'an, Shaanxi, 710038
Status
Address
Duplicate_Huashan Hospital of Fudan University /ID# 159999
Shanghai, Shanghai, 200040
Status
Address
Duplicate_The Second Affiliated Hospital of ZUSM /ID# 165593
Hangzhou, Zhejiang, 310009
Status
Address
Beijing Tian Tan Hospital, Capital Medical University /ID# 167160
Beijing, , 100070
Status
Address
The First Affiliated Hospital of Fujian Medical University /ID# 159166
Fuzhou, , 350005
Status
Address
Duplicate_Shengjing Hospital of China Medical University /ID# 167016
Shenyang, , 110004
Status
Address
Duplicate_Tianjin Med Univ General Hosp /ID# 143923
Tianjin, , 300052
Status
Address
Hospital Pablo Tobon Uribe /ID# 143780
Medellín, Antioquia, 50034
Status
Address
Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 147223
Monteria, Cordoba, 230002
Status
Address
Administradora del Country_S.A-Clinica Del Country /ID# 143881
Bogota, Cundinamarca, 110221
Status
Address
Oncologos del Occidente S.A /ID# 147713
Pereira, Risaralda, 66000
Status
Address
Centro Medico Imbanaco de Cali /ID# 143882
Cali, ,
Status
Address
Masarykuv onkologicky ustav /ID# 143884
Brno, , 656 53
Status
Address
Duplicate_FN Hradec Kralove /ID# 143885
Hradec Kralove, , 500 05
Status
Address
Krajska nemocnice Liberec, a.s. /ID# 142024
Liberec, , 460 01
Status
Address
Duplicate_Univ Hosp Ostrava-Poruba /ID# 143883
Ostrava, , 708 52
Status
Address
Fakultni Nemocnice v Motole /ID# 142023
Praha, , 150 06
Status
Address
AP-HM - Hopital de la Timone /ID# 143911
Marseille CEDEX 05, Bouches-du-Rhone, 13385
Status
Address
CHRU Lille - Hopital Claude Huriez /ID# 143915
Lille, Hauts-de-France, 59037
Status
Address
Hopital Avicenne - APHP /ID# 143910
Bobigny, Ile-de-France, 93000
Status
Address
Duplicate_Gustave Roussy /ID# 143912
Villejuif Cedex, Ile-de-France, 94805
Status
Address
Institut de Cancérologie de l'Ouest René Gauducheau /ID# 143914
St Herblain CEDEX, Loire-Atlantique, 44805
Status
Address
CHU Nice -Hopital Pasteur /ID# 143916
Nice CEDEX 1, Provence-Alpes-Cote-d Azur, 06002
Status
Address
Insititut de Cancerologie /ID# 143908
Angers, , 49933
Status
Address
Hopital Pitie Salpetriere /ID# 143917
Paris, , 75013
Status
Address
Universitaetsklinik Heidelberg /ID# 143927
Heidelberg, Baden-Wuerttemberg, 69120
Status
Address
Universitaetsklinikum Tuebingen /ID# 143926
Tubingen, Baden-Wuerttemberg, 72076
Status
Address
Universitaetsklinikum Leipzig /ID# 143962
Leipzig, Sachsen, 04103
Status
Address
Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH /ID# 143961
Bochum, , 44791
Status
Address
Prince of Wales Hospital /ID# 143952
Hong Kong, , 999077
Status
Address
Beaumont Hospital /ID# 142969
Beaumont, Dublin, D09 XR63
Status
Address
The Chaim Sheba Medical Center /ID# 143960
Ramat Gan, Tel-Aviv, 5265601
Status
Address
Tel Aviv Sourasky Medical Center /ID# 143956
Tel Aviv-Yafo, Tel-Aviv, 6423906
Status
Address
Rambam Health Care Campus /ID# 143959
Haifa, , 3109601
Status
Address
Gastroenterology Institute, Division of Medicine /ID# 143958
Jerusalem, , 91120
Status
Address
Rabin Medical Center /ID# 143957
Petakh Tikva, , 4941492
Status
Address
Duplicate_Duplicate_AOU Citta della Salute Scienza /ID# 141801
Turin, Piemonte, 10126
Status
Address
Fondazione IRCCS Istituto Neurologico Carlo Besta /ID# 141800
Milan, , 20133
Status
Address
Istituto Oncologico Veneto /ID# 143821
Padova, , 35128
Status
Address
Duplicate_Regina Elena National Cancer I /ID# 141795
Rome, , 00144
Status
Address
National Cancer Center /ID# 141845
Goyang, Gyeonggido, 10408
Status
Address
Duplicate_Yonsei University Health System, Severance hospital. /ID# 141846
Seoul, Seoul Teugbyeolsi, 03722
Status
Address
Seoul National University Hospital /ID# 143886
Seoul, , 03080
Status
Address
Samsung Medical Center /ID# 143887
Seoul, , 06351
Status
Address
The Catholic University of Korea, Seoul St. Mary's Hospital /ID# 141844
Seoul, , 06591
Status
Address
Centro Medico Zambrano Hellion /ID# 143845
San Pedro Garza Garcia, Nuevo Leon, 66278
Status
Address
Vrije Universiteit Medisch Centrum /ID# 143889
Amsterdam, , 1081 HV
Status
Address
Haaglanden Medisch Centrum /ID# 141405
Den Haag, , 2512 VA
Status
Address
Universitair Medisch Centrum Groningen /ID# 141408
Groningen, , 9713 GZ
Status
Address
Maastricht Universitair Medisch Centrum /ID# 143585
Maastricht, , 6229 HX
Status
Address
Universitair Medisch Centrum Utrecht /ID# 141406
Utrecht, , 3584 CX
Status
Address
Duplicate_Canterbury District Health Boa /ID# 143861
Christchurch, , 8011
Status
Address
Duplicate_Wellington Hospital (Capital and Coast District Health Board) /ID# 143890
Wellington, , 6021
Status
Address
CCA Braga - Hospital de Braga /ID# 141940
Braga, , 4710-243
Status
Address
Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 141939
Faro, , 8000-386
Status
Address
IPO Lisboa FG, EPE /ID# 141938
Lisboa, , 1099-023
Status
Address
Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 141941
Lisboa, , 1649-035
Status
Address
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 142830
Porto, , 4200-319
Status
Address
Regional Clinical Hospital of Kaliningrad region /ID# 141702
Kaliningrad, Kaliningradskaya Oblast, 236016
Status
Address
State budgetary healthcare institution Republican Clinical Oncology Dispensary /ID# 141706
Ufa, Kirovskaya Oblast, 450054
Status
Address
GEMC - European Medical Center /ID# 141703
Moscow, Moskovskaya Oblast, 129090
Status
Address
Federal State Budgetary Scientific Institution N.N. Blokhin /ID# 141707
Moscow, Moskva, 115478
Status
Address
National Medical Research Center for Neurosurgery n.a. N. N. Burdenko /ID# 141701
Moscow, Moskva, 125047
Status
Address
Federal State Treatment and Rehabilitation center /ID# 141704
Moscow, Moskva, 125367
Status
Address
Sverdlovsk Regional Oncology Dispensary /ID# 141700
Yekaterinburg, Sverdlovskaya Oblast, 620043
Status
Address
National University Hospital /ID# 143933
Singapore, , 119074
Status
Address
National Cancer Ctr Singapore /ID# 143932
Singapore, , 169610
Status
Address
University of Free State, Universitas Annex (National Hospital Grounds) /ID# 144064
Bloemfontein, Free State, 9301
Status
Address
Netcare Unitas Hospital /ID# 152936
Centurion, Gauteng, 0140
Status
Address
The Oncology Centre /ID# 143950
Durban, Kwazulu-Natal, 4091
Status
Address
Netcare Oncology Intervent Ctr /ID# 143951
Cape Town, Western Cape, 7460
Status
Address
Rondebosch Oncology Center /ID# 143949
Cape Town, Western Cape, 7700
Status
Address
Cape Town Oncology Trials /ID# 143948
Kraaifontein, Western Cape, 7570
Status
Address
Hospital Regional de Malaga /ID# 143902
Málaga, Malaga, 29010
Status
Address
Hospital Clinic de Barcelona /ID# 143906
Barcelona, , 08036
Status
Address
Hospital Santa Creu i Sant Pau /ID# 143900
Barcelona, , 08041
Status
Address
Hospital Clinico Universitario San Carlos /ID# 143901
Madrid, , 28040
Status
Address
Hospital Universitario 12 de Octubre /ID# 143930
Madrid, , 28041
Status
Address
Hospital Universitario HM Sanchinarro /ID# 143496
Madrid, , 28050
Status
Address
Hospital General Universitario de Valencia /ID# 143903
Valencia, , 46014
Status
Address
Kantonsspital Aarau AG /ID# 141885
Aarau, Aargau, 5001
Status
Address
Universitatsspital Zurich /ID# 141887
Zurich, Zuerich, 8091
Status
Address
Duplicate_EOC Ospedale Regionale di Bellinzona e Valli /ID# 143936
Bellinzona, , 6500
Status
Address
Inselspital, Universitätsspital Bern /ID# 141886
Bern, , 3010
Status
Address
National Taiwan University Hospital /ID# 143940
Taipei City, , 100
Status
Address
Taipei Veterans General Hosp /ID# 143955
Taipei City, , 11217
Status
Address
Linkou Chang Gung Memorial Hospital /ID# 143941
Taoyuan City, , 333
Status
Address
Guys and St Thomas NHS Foundation Trust /ID# 142652
London, London, City Of, SE1 9RT
Status
Address
University Hospitals Birmingham NHS Foundation Trust /ID# 154592
Birmingham, , B15 2TH
Status
Address
Velindre University NHS Trust /ID# 141996
Cardiff, , CF15 7QZ
Status
Address
Duplicate_NHS Tayside /ID# 141651
Dundee, , DD2 1UB
Status
Address
NHS Lothian /ID# 141802
Edinburgh, , EH3 9HE
Status
Address
Leeds Teaching Hospitals NHS Trust /ID# 141653
Leeds, , LS9 7TF
Status
Address
University College London Hospitals NHS Foundation Trust /ID# 142658
London, , NW1 2PG
Status
Address
Duplicate_The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 141999
Newcastle Upon Tyne, , NE7 7DN
Status
Address
Royal Marsden Hospital /ID# 142827
Sutton, , SM2 5PT
