Inclusion Criteria. 1. Age: Patients must be ≥2 years and ≤21 years of age. 2. Diagnosis: Patients with relapsed or refractory central nervous system tumors.
Patients must have had histological verification of malignancy at original diagnosis
or relapse. Metastatic disease to the spine or primary tumors in the spine are
eligible. Patients may be in first, second, or third relapse. Subjects with
intrinsic brain stem gliomas may be eligible with or without histological
confirmation. Please contact study chair prior to enrollment.
3. Disease Status: Patients must have measurable disease. Linear enhancement of
leptomeningeal without measurable mass is excluded.
4. Therapeutic Options: Patient's current disease state must be one for which there is
no accepted standard therapy, no known curative therapy or therapy proven to prolong
survival with an acceptable quality of life. For patients in whom surgery is
feasible, maximal surgical resection must have occurred.
5. Performance Level: Karnofsky ≥ 50% for patients > 16 years of age and Lansky ≥ 50
for patients ≤ 16 years of age (See Appendix 1). Note: Neurologic deficits in
patients must have been relatively stable for at least 7 days prior to study
enrollment. Patients who are unable to walk because of paralysis, but who are in a
wheelchair, will be considered ambulatory for the purpose of assessing the
performance score.
6. Subjects must have a reasonable life expectancy of at least 2 months.
7. Prior Therapy. a. Patients must have fully recovered from the acute toxic effects of all prior
anti-cancer chemotherapy i. Cytotoxic chemotherapy (including investigational
agents) or biologic agents (eg. Cytokines or antibodies): At least 3 weeks after the
last dose.
ii. Nitrosoureas/mitomycin C: At least 6 weeks from the last dose. iii. XRT: At
least 14 days after local palliative XRT (small port); At least 150 days must have
elapsed if prior TBI, craniospinal XRT or if ≥ 50% radiation of pelvis; At least 42
days must have elapsed if other substantial BM radiation. e.g. Stem cell Infusion
without TBI: No evidence of active graft vs. host disease and at least 56 days must
have elapsed after transplant or stem cell infusion.
8. Organ Function Requirements:
a. Adequate bone marrow function defined as: absolute neutrophil count (ANC
≥1000/mm3) i. Platelet count ≥ 100,000/ mm3 (transfusion independent, defined as not
receiving platelet transfusions for at least 7 days prior to enrollment) ii.
Patients with bone marrow metastatic disease will not be eligible. b. Adequate renal
function defined as: i. Creatinine clearance or radioisotope GFR ≥ 70mL/min/1.73 m²
or a serum creatinine based on age/gender as follows:
Age Maximum Serum Creatinine (mg/dL) Male Female 2 to < 6 years 0.8 0.8 6 to < 10
years 1 1 10 to < 13 years 1.2 1.2 13 to < 16 years 1.5 1.4. ≥ 16 years 1.7 1.4 The threshold creatinine values in this table were derived from
the Schwartz formula for estimating GFR (Schwartz et al. J. Peds, 106:522, 1985)
utilizing child length and stature data published by the CDC.
ii. Urine protein: ≤ 30 mg/dL in urinalysis or ≤ 1+ on dipstick, unless quantitative
protein is < 1000 mg in a 24 hour urine sample.
c. Adequate Liver Function Defined as:
i. Bilirubin (sum of conjugated + unconjugated) ≤ 1.5 x upper limit of normal (ULN)
for age ii. SGPT (ALT) ≤ 110 U/L. For the purpose of this study, the ULN for SGPT is
45 U/L.
iii. Serum albumin ≥ 2.8 g/dL. d. Adequate coagulation status defined as: PT and INR
≤ 1.5x ULN e. Adequate pancreatic function defined as: Serum amylase and lipase ≤
1.5 x ULN f. Adequate blood pressure control defined as: A blood pressure (BP) ≤ the
95th percentile for age, height and gender (Appendix II) despite optimal
antihypertensive treatment within 7 days of the first dose of the study treatment.
Please note that 3 serial blood pressures should be obtained and averaged to
determine baseline BP.
g. Central nervous system function defined as: Patients with seizure disorder may be
enrolled if receiving non-enzyme inducing anticonvulsants and well controlled. See
Appendix III for a list of recommended non-enzyme inducing anticonvulsants.
h. Adequate cardiac function defined as: i. No history of congenital QTc syndrome,
NYHA Class III or IV congestive heart failure (CHF) ii. No clinical significant
cardiac arrhythmias, stroke or myocardial infarction within 6 months prior to
enrollment iii. QTc. ≤ 480 msec. Note: One ECG must be performed for eligibility determination. If the
QTc is > 480 msec, two additional ECGs must be performed and the average of the
three ECGs will be used to determine eligibility. Patients with Grade 1 prolonged
QTc (450-480 msec) at the time of study enrollment should have correctable causes of
prolonged QTc addressed if possible (i.e. electrolytes, medications). See Appendix
IV for a list of drugs that prolong QTc.
9. Informed consent: All patients and/or their parents or legally authorized
representatives must sign a written informed consent. Assent, when appropriate will
be obtained according to institutional guidelines.
10. Archival tumor tissue slides must be sent or available, except for patients with
intrinsic pontine glioma meeting the remainder of the inclusion criteria.
Exclusion Criteria. 1. Pregnancy or Breast-Feeding: Pregnant or breast-feeding women will not be entered on
this study due to risks of fetal and teratogentic adverse events as seen in
animal/human studies. Pregnancy tests must be obtained in girls who are
post-menarchal. Males or females of reproductive potential may not participate
unless they have agreed to use two methods of birth control- a medically accepted
barrier method of contraceptive method (e.g., male or female condom) and a second
effective method of birth control- during protocol therapy and for at least 4 months
after the last dose of cabozantinib. Abstinence is an acceptable method of birth
control.
2. Concomitant Medications:
1. Corticosteroids: Patients receiving corticosteroids who have not been on a
stable or decreasing dose of corticosteroid for at least 7 days prior to
enrollment are not eligible.
2. Investigational drugs: Patients who are currently receiving another
investigational drug are not eligible.
3. Anti-cancer agents: patients who are currently receiving other anti-cancer
agents are not eligible.
4. CYP3A4 active agents: Patients must not be receiving any of the following
potent CYP3A4 inducers or inhibitors: erythromycin, clarithromycin,
ketoconazole, azithromycin, itraconazole, grapefruit juice or St. John's wort.
A list of other known CYP3A4 inducers and inhibitors that should be
discontinued prior to initiation of protocol therapy and should be avoided
during study therapy if reasonable alternatives exist is included in Appendix
Patients who are receiving systemic therapeutic treatment anticoagulation are
not eligible. Patients receiving prophylactic systemic anticoagulation will be
allowed with heparin or LMWH as long as eligibility PT/INR requirements are
met. Concomitant anticoagulation with oral anticoagulations (e.g. warfarin,
direct thrombin and Factor Xa inhibitors) or platelet inhibitors (eg.
Clopidogrel) are not allowed.
6. Enzyme-inducing anticonvulsants: Patients must not have received
enzyme-inducing anticonvulsants within 14 days prior to enrollment (See
Appendix III for a list of unacceptable enzyme inducing anticonvulsants).
7. QTc Agents: Patients who are receiving drugs that prolong QTc are not eligible
(See Appendix IV for a list of agents).
3. Patients must be able to swallow intact tablets. Patients who cannot swallow intact
tablets are not eligible.
4. Patients with active bleeding are not eligible. Specifically, no clinically
significant GI bleeding, GI perforation, intra-abdominal abscess or fistula for 6
months prior to enrollment, no hemoptysis or other signs of pulmonary hemorrhage for
3 months prior to enrollment.
5. Patients with evidence of an acute intracranial or intratumoral hemorrhage on CT or
MRI are not eligible (patients with evidence of resolving hemorrhage will be
eligible).
6. Major surgery within 28 days of enrollment. Complete wound healing from major or
minor surgery must have occurred prior to enrollment. Minor surgery (including
uncomplicated tooth extractions) within 7 days of enrollment. Subjects with
clinically relevant ongoing complications from prior surgery are not eligible;
7. Concurrent uncontrolled hypertension defined as sustained blood pressure>95% for
age, height and gender (systolic or diastolic) despite optimal antihypertensive
treatment within 7 days of the first dose of study treatment.
8. Patients with any medical or surgical conditions that would interfere with
gastrointestinal absorption of this oral agent are not eligible.
9. Infection: Patients who have an uncontrolled infection are not eligible.
10. Patients who have received a prior solid organ transplantation are not eligible.
11. Patients who in the opinion of the investigator may not be able to comply with the
safety monitoring requirements of the study are not eligible.
12. Subjects who have received cabozantinib or have an allergy to cabozantinib are
excluded. Subjects who have previously received tyrosine kinase inhibitors are
allowed.
13. Subjects who have not received radiation therapy as part of their prior treatment
are excluded.
