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Integrative Analysis of Human Glioblastoma Multiforme

Study Purpose

Integrative analysis of GBM

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Observational
Eligible Ages 18 Years - 75 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Age ≤ 75 years with histologically proven GBM.
  • - No severe major organ dysfunction.
  • - World Health Organization (WHO) performance status of 0 or 1.
  • - No prior cancer chemotherapy.

Exclusion Criteria:

  • - Age ≥ 76.
  • - Severe major organ dysfunction.
  • - WHO performance status of >1.
- Prior cancer chemotherapy

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03005132
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Shanghai 10th People's Hospital
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Da Fu, PhDXiaoming Zhong, MD
Principal Investigator Affiliation Shanghai 10th People's HospitalGanzhou City People's Hospital
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Recruiting
Countries China
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

GBM
Additional Details

The investigators will analyzed proteomes of paired normal brain tissues and GBM, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal brain tissue, primary GBM carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of GBM characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.

Arms & Interventions

Arms

: Normal brain tissue

Normal brain tissue from GBM patients

: GBM tissues

GBM tissues from GBM patients

: Metastasis tissues

Metastasis tissues from GBM patients

Interventions

Other: - Normal brain tissue

The investigators will extract total protein, DNA and RNA from the samples.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

International Sites

Shanghai Tenth People's Hospital, Shanghai, Shanghai, China

Status

Recruiting

Address

Shanghai Tenth People's Hospital

Shanghai, Shanghai, 200072

Site Contact

Da Fu, PhD

[email protected]

00-86-21-66301604