Testing Ramipril to Prevent Memory Loss in People With Glioblastoma
Study Purpose
This study is to determine if an oral drug called Ramipril can lower the chance of memory loss in patients with glioblastoma getting chemoradiation. Patients will take Ramipril during chemoradiation and continue until 4 months post-treatment. Memory loss will be assessed using several neurocognitive tests throughout the duration of the study.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Histologically proven diagnosis of glioblastoma or gliosarcoma (World Health Organization [WHO] grade IV) obtained at the time of a partial or gross total resection of the tumor.
- - The tumor must have a supratentorial component.
- - History/physical examination within 14 days prior to enrollment.
- - The patient must have recovered from the effects of surgery, postoperative infection, and other complications before enrollment.
- - Patient planning to receive brain RT, and concurrent and adjuvant temozolomide chemotherapy for six weeks as per standard of care therapy.
- - Study drug (Ramipril) must be given >= 21 days and ≤ 42 days after surgery.
- - All available brain magnetic resonance imaging (MRI) or computed tomography (CT) imaging reports from surgery to study completion must be submitted.
- - Eastern Cooperative Oncology Group (ECOG) 0, 1 or 2.
- - Absolute neutrophil count (ANC) >= 1,500 cells/mm^3 (obtained within 14 days prior to enrollment) - Platelets >= 100,000 cells/mm^3 (obtained within 14 days prior to enrollment) - Hemoglobin >= 10.0 g/dl (Note: The use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 10.0 g/dl is acceptable) (obtained within 14 days prior to enrollment) - Blood urea nitrogen (BUN) =< 30 mg/dl within 14 days prior to enrollment.
- - Creatinine =< 1.7 mg/dl within 14 days prior to enrollment.
- - Total bilirubin =< 2.0 mg/dl within 14 days prior to enrollment.
- - Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 3 x normal range within 14 days prior to enrollment.
- - Patient must provide study specific informed consent prior to study entry.
- - Baseline potassium level <5.0 mEq/L.
- - Women of childbearing potential and male participants must practice adequate contraception.
- - For females of child-bearing potential, negative serum or urine pregnancy test within 14 days of enrollment.
- - Local site must be follow the standard GBM radiation treatment dosimetry plan.
- - For patients who will be treated with the Optune® device in addition to standard of care radiation plus concurrent and adjuvant temozolomide, the following inclusion criteria also apply: - Patients must have only a supratentorial glioblastoma.
- - The treating physician must be a qualified provider having successfully completed the training course provided by Novocure, the device manufacturer.
- - Patients with prior malignancies if all treatment for that malignancy was completed at least 2 years before registration and the patient has no evidence of disease.
Exclusion Criteria:
- - Prior allergic reaction or intolerance to angiotensin-converting-enzyme (ACE) inhibitor.
- - Hypotension (< 110 mg Hg systolic) at the time of enrollment.
- - Renal insufficiency with creatinine clearance of < 40 ml/min (at time of enrollment) - Solitary kidney or known renal artery stenosis.
- - Current ACE inhibitor or angiotensin receptor blocker use.
- - Prior invasive malignancy (except for non-melanomatous skin cancer) unless disease free for ≥ 2 years.
- - Recurrent or multifocal malignant gliomas.
- - Metastases detected below the tentorium or beyond the cranial vault.
- - Prior chemotherapy or radiosensitizers for cancers of the head and neck region; note that prior chemotherapy for a different cancer is allowable, except prior temozolomide.
- - Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in overlap of radiation fields.
- - Severe active co-morbidity, defined as follows: - Acute bacterial or fungal infection requiring intravenous antibiotics at the time of enrollment.
- - Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of enrollment.
- - Known HIV positivity or acquired immune deficiency syndrome (AIDS) based upon current CDC definition; note, however, that HIV testing is not required for entry into this protocol.
- - Active connective tissue disorders, such as lupus or scleroderma, that in the opinion of the treating physician may put the patient at high risk for radiation toxicity.
- - Any other major medical illnesses or psychiatric impairments that in the investigator's opinion will prevent administration or completion of protocol therapy.
- - Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic.
- - Patients treated on any other therapeutic clinical protocols within 30 days prior to study entry or during participation in the study unless they involve standard of care or over the counter therapies or do not involve a drug therapy.
- - Patients planning to receive therapeutic antitumor agents (excluding use of the Tumor Treating Fields (TTFields or Optune®) device after the Month 1 Post RT (10 wk) Neurocognitive-PRO assessment.
- - Patients with impaired decision-making capacity; this exclusion is necessary because such patients may not be able to adequately give informed consent.
- - Pregnant or lactating women, due to possible adverse effect on the developing fetus or infant due to study drug.
- - For patients who will be treated with the Optune® device in addition to standard of care radiation plus concurrent and adjuvant temozolomide, the following exclusion criteria also apply: - Optune® is not permitted in patients who have an active implanted medical device, skull defect (such as, missing bone with no replacement) or bullet fragments.
- - Optune® is not permitted in patients who are known to be sensitive to conductive hydrogels.
- - Patients being treated with Memantine, Donepezil, and/or medications prescribed to enhance cognition.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT03475186 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Wake Forest University Health Sciences |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Michael D Chan, MD |
| Principal Investigator Affiliation | Wake Forest University Health Sciences |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Active, not recruiting |
| Countries | Guam, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Glioblastoma, Radiotherapy; Complications, Cognitive Decline, Chemoradiation |
This is a pilot study of an oral drug Ramipril to prevent cognitive decline in glioblastoma patients receiving partial brain radiation and concurrent and adjuvant temozolomide . Ramipril will be titrated to the highest tolerable dose during chemoradiation (2.5-5 mg). Once this dose is determined, the patient will continue at this dose for 4 months after the completion of chemoradiation. Patients will be followed until 5 months post chemoradiation for compliance, toxicity, cognitive decline and participant reported outcomes (PRO).
Arms
Experimental: Ramipril
Ramipril will be taken once daily by mouth. It will be titrated during the first 3 weeks of chemoradiation to the highest tolerable dose (2.5-5 mg). This dose will be taken each day until 4 months post-chemoradiation treatment (22 weeks).
Interventions
Drug: - Ramipril
2.5 - 5 mg oral, 1x daily for 22 weeks
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
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Anchorage Associates in Radiation Medicine
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Beebe Medical Center
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Delaware Clinical and Laboratory Physicians PA
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Helen F Graham Cancer Center
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Christiana Care Health System-Christiana Hospital
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Holy Cross Hospital
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Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida, 33905
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Carle Cancer Institute Normal
Atlanta, Georgia, 30310
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Northside Hospital
Atlanta, Georgia, 30342
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Northside Hospital - Duluth
Duluth, Georgia, 30096
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Northside Hospital - Gwinnett
Lawrenceville, Georgia, 30046
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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405
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Suburban Hematology Oncology Associates - Snellville
Snellville, Georgia, 30078
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Hawaii Cancer Care - Savio
'Aiea, Hawaii, 96701
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Hawaii Cancer Care - Westridge
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Pali Momi Medical Center
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The Cancer Center of Hawaii-Pali Momi
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The Queen's Medical Center - West Oahu
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Hawaii Cancer Care Inc - Waterfront Plaza
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Island Urology
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Queen's Cancer Cenrer - POB I
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Queen's Medical Center
Honolulu, Hawaii, 96813
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Straub Clinic and Hospital
Honolulu, Hawaii, 96813
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University of Hawaii Cancer Center
Honolulu, Hawaii, 96813
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Hawaii Diagnostic Radiology Services LLC
Honolulu, Hawaii, 96817
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Kuakini Medical Center
Honolulu, Hawaii, 96817
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Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
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The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817
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Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
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Straub Medical Center - Kahului Clinic
Kahului, Hawaii, 96732
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Castle Medical Center
Kailua, Hawaii, 96734
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Wilcox Memorial Hospital and Kauai Medical Clinic
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Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
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Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
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Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
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Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687
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Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
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OSF Saint Anthony's Health Center
Alton, Illinois, 62002
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Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
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Illinois CancerCare-Canton
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Memorial Hospital of Carbondale
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SIH Cancer Institute
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Illinois CancerCare-Carthage
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Centralia Oncology Clinic
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Cancer Care Specialists of Illinois - Decatur
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Decatur Memorial Hospital
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Heartland Cancer Research NCORP
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Illinois CancerCare-Dixon
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Carle Physician Group-Effingham
Effingham, Illinois, 62401
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Crossroads Cancer Center
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Illinois CancerCare-Eureka
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Illinois CancerCare-Galesburg
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Western Illinois Cancer Treatment Center
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Illinois CancerCare-Kewanee Clinic
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Illinois CancerCare-Macomb
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Mattoon, Illinois, 61938
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Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
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Illinois CancerCare-Pekin
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Illinois CancerCare-Peoria
Peoria, Illinois, 61615
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Methodist Medical Center of Illinois
Peoria, Illinois, 61636
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Illinois CancerCare-Peru
Peru, Illinois, 61354
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Illinois CancerCare-Princeton
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Southern Illinois University School of Medicine
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Springfield, Illinois, 62781
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Springfield Memorial Hospital
Springfield, Illinois, 62781
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Carle Cancer Center NCI Community Oncology Research Program
Urbana, Illinois, 61801
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Carle Cancer Center
Urbana, Illinois, 61801
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The Carle Foundation Hospital
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Illinois CancerCare - Washington
Washington, Illinois, 61571
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Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
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Saint Anthony Regional Hospital
Carroll, Iowa, 51401
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Saint Luke's Hospital
Cedar Rapids, Iowa, 52402
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Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, 50325
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Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
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Alegent Health Mercy Hospital
Council Bluffs, Iowa, 51503
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Greater Regional Medical Center
Creston, Iowa, 50801
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Iowa Methodist Medical Center
Des Moines, Iowa, 50309
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Iowa-Wide Oncology Research Coalition NCORP
Des Moines, Iowa, 50309
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Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, 50309
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Broadlawns Medical Center
Des Moines, Iowa, 50314
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Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, 50314
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Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
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Iowa Lutheran Hospital
Des Moines, Iowa, 50316
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Trinity Regional Medical Center
Fort Dodge, Iowa, 50501
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Methodist West Hospital
West Des Moines, Iowa, 50266-7700
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Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
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Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
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Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
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Lawrence Memorial Hospital
Lawrence, Kansas, 66044
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Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208
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Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214
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Cancer Center of Kansas - Wichita
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Flaget Memorial Hospital
Bardstown, Kentucky, 40004
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Commonwealth Cancer Center-Corbin
Corbin, Kentucky, 40701
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Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
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Saint Joseph Hospital East
Lexington, Kentucky, 40509
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Saint Joseph London
London, Kentucky, 40741
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Jewish Hospital
Louisville, Kentucky, 40202
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Saints Mary and Elizabeth Hospital
Louisville, Kentucky, 40215
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Jewish Hospital Medical Center South
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Ann Arbor, Michigan, 48106
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Bronson Battle Creek
Battle Creek, Michigan, 49017
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IHA Hematology Oncology Consultants-Brighton
Brighton, Michigan, 48114
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Saint Joseph Mercy Brighton
Brighton, Michigan, 48114
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IHA Hematology Oncology Consultants-Canton
Canton, Michigan, 48188
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Saint Joseph Mercy Canton
Canton, Michigan, 48188
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Caro Cancer Center
Caro, Michigan, 48723
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IHA Hematology Oncology Consultants-Chelsea
Chelsea, Michigan, 48118
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Saint Joseph Mercy Chelsea
Chelsea, Michigan, 48118
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Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, 48346
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Newland Medical Associates-Clarkston
Clarkston, Michigan, 48346
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Detroit, Michigan, 48236
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Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan, 48503
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Genesee Hematology Oncology PC
Flint, Michigan, 48503
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Genesys Hurley Cancer Institute
Flint, Michigan, 48503
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Hurley Medical Center
Flint, Michigan, 48503
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Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids, Michigan, 49503
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Mercy Health Saint Mary's
Grand Rapids, Michigan, 49503
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Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, 49503
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Academic Hematology Oncology Specialists
Grosse Pointe Woods, Michigan, 48236
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Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan, 48236
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Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods, Michigan, 48236
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Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
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West Michigan Cancer Center
Kalamazoo, Michigan, 49007
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Borgess Medical Center
Kalamazoo, Michigan, 49048
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Sparrow Hospital
Lansing, Michigan, 48912
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Saint Mary Mercy Hospital
Livonia, Michigan, 48154
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Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan, 48044
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Michigan Breast Specialists-Macomb Township
Macomb, Michigan, 48044
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Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan, 48453
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Mercy Health Mercy Campus
Muskegon, Michigan, 49444
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Lakeland Hospital Niles
Niles, Michigan, 49120
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Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan, 49444
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Ascension Borgess Cancer Center
Oshtemo, Michigan, 49008
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21st Century Oncology-Pontiac
Pontiac, Michigan, 48341
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Hope Cancer Center
Pontiac, Michigan, 48341
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Newland Medical Associates-Pontiac
Pontiac, Michigan, 48341
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Saint Joseph Mercy Oakland
Pontiac, Michigan, 48341
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Spectrum Health Reed City Hospital
Reed City, Michigan, 49677
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Ascension Saint Mary's Hospital
Saginaw, Michigan, 48601
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Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan, 48604
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Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan, 49085
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Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
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Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan, 48312
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Ascension Saint Joseph Hospital
Tawas City, Michigan, 48764
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Munson Medical Center
Traverse City, Michigan, 49684
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Advanced Breast Care Center PLLC
Warren, Michigan, 48088
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Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan, 48093
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Macomb Hematology Oncology PC
Warren, Michigan, 48093
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Michigan Breast Specialists-Warren
Warren, Michigan, 48093
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Saint John Macomb-Oakland Hospital
Warren, Michigan, 48093
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Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan, 48661
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Metro Health Hospital
Wyoming, Michigan, 49519
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Huron Gastroenterology PC
Ypsilanti, Michigan, 48106
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IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, Michigan, 48197
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Riverwood Healthcare Center
Aitkin, Minnesota, 56431
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Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
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Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, 56401
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Fairview Ridges Hospital
Burnsville, Minnesota, 55337
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Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
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Cambridge Medical Center
Cambridge, Minnesota, 55008
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Mercy Hospital
Coon Rapids, Minnesota, 55433
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Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636
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Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, 56501
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Essentia Health Cancer Center
Duluth, Minnesota, 55805
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Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, 55805
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Miller-Dwan Hospital
Duluth, Minnesota, 55805
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Fairview Southdale Hospital
Edina, Minnesota, 55435
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Lake Region Healthcare Corporation-Cancer Care
Fergus Falls, Minnesota, 56537
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Essentia Health - Fosston
Fosston, Minnesota, 56542
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Unity Hospital
Fridley, Minnesota, 55432
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Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746
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Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
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Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
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Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
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Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
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Hennepin County Medical Center
Minneapolis, Minnesota, 55415
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Health Partners Inc
Minneapolis, Minnesota, 55454
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Monticello Cancer Center
Monticello, Minnesota, 55362
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New Ulm Medical Center
New Ulm, Minnesota, 56073
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Essentia Health - Park Rapids
Park Rapids, Minnesota, 56470
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Fairview Northland Medical Center
Princeton, Minnesota, 55371
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North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
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Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
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Regions Hospital
Saint Paul, Minnesota, 55101
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United Hospital
Saint Paul, Minnesota, 55102
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Essentia Health Sandstone
Sandstone, Minnesota, 55072
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Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Status
Address
Lakeview Hospital
Stillwater, Minnesota, 55082
Status
Address
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota, 56701
Status
Address
Essentia Health Virginia Clinic
Virginia, Minnesota, 55792
Status
Address
Ridgeview Medical Center
Waconia, Minnesota, 55387
Status
Address
Rice Memorial Hospital
Willmar, Minnesota, 56201
Status
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Status
Address
Sanford Cancer Center Worthington
Worthington, Minnesota, 56187
Status
Address
Fairview Lakes Medical Center
Wyoming, Minnesota, 55092
Status
Address
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, 63011
Status
Address
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
Status
Address
Cox Cancer Center Branson
Branson, Missouri, 65616
Status
Address
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Status
Address
Southeast Cancer Center
Cape Girardeau, Missouri, 63703
Status
Address
Parkland Health Center - Farmington
Farmington, Missouri, 63640
Status
Address
Capital Region Southwest Campus
Jefferson City, Missouri, 65109
Status
Address
Freeman Health System
Joplin, Missouri, 64804
Status
Address
Mercy Hospital Joplin
Joplin, Missouri, 64804
Status
Address
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, 65401
Status
Address
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
Status
Address
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
Status
Address
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri, 63109
Status
Address
Mercy Hospital South
Saint Louis, Missouri, 63128
Status
Address
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
Status
Address
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
Status
Address
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
Status
Address
Mercy Hospital Springfield
Springfield, Missouri, 65804
Status
Address
CoxHealth South Hospital
Springfield, Missouri, 65807
Status
Address
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
Status
Address
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri, 63127
Status
Address
Mercy Hospital Washington
Washington, Missouri, 63090
Status
Address
Saint Patrick Hospital - Community Hospital
Missoula, Montana, 59802
Status
Address
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803
Status
Address
CHI Health Good Samaritan
Kearney, Nebraska, 68847
Status
Address
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska, 68510
Status
Address
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Status
Address
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Status
Address
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
Status
Address
Creighton University Medical Center
Omaha, Nebraska, 68131
Status
Address
Midlands Community Hospital
Papillion, Nebraska, 68046
Status
Address
AtlantiCare Health Park-Cape May Court House
Cape May Court House, New Jersey, 08210
Status
Address
AtlantiCare Surgery Center
Egg Harbor Township, New Jersey, 08234
Status
Address
Lovelace Medical Center-Downtown
Albuquerque, New Mexico, 87102
Status
Address
Lovelace Medical Center-Saint Joseph Square
Albuquerque, New Mexico, 87102
Status
Address
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87102
Status
Address
Lovelace Radiation Oncology
Albuquerque, New Mexico, 87109
Status
Address
Northwell Health Imbert Cancer Center
Bay Shore, New York, 11706
Status
Address
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
Status
Address
Cone Health Cancer Center at Asheboro
Asheboro, North Carolina, 27203
Status
Address
Randolph Hospital
Asheboro, North Carolina, 27203
Status
Address
Mission Hospital
Asheville, North Carolina, 28801
Status
Address
Cone Health Cancer Center at Alamance Regional
Burlington, North Carolina, 27215
Status
Address
Wake Forest University at Clemmons
Clemmons, North Carolina, 27012
Status
Address
Central Carolina Surgery
Greensboro, North Carolina, 27401
Status
Address
Cone Health Cancer Center
Greensboro, North Carolina, 27403
Status
Address
Novant Health Breast Surgery - Greensboro
Greensboro, North Carolina, 27403
Status
Address
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, 28791
Status
Address
Novant Health Cancer Institute - Kernersville
Kernersville, North Carolina, 27284
Status
Address
Cone Heath Cancer Center at Mebane
Mebane, North Carolina, 27302
Status
Address
Novant Health Cancer Institute - Mount Airy
Mount Airy, North Carolina, 27030
Status
Address
Annie Penn Memorial Hospital
Reidsville, North Carolina, 27320
Status
Address
Novant Health Cancer Institute - Statesville
Statesville, North Carolina, 28625
Status
Address
Novant Health Cancer Institute - Thomasville
Thomasville, North Carolina, 27360
Status
Address
Novant Health Cancer Institute - Wilkesboro
Wilkesboro, North Carolina, 28659
Status
Address
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro, North Carolina, 28659
Status
Address
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina, 27103
Status
Address
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Status
Address
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Status
Address
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, 58103
Status
Address
Sanford South University Medical Center
Fargo, North Dakota, 58103
Status
Address
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota, 58103
Status
Address
Sanford Medical Center Fargo
Fargo, North Dakota, 58104
Status
Address
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Status
Address
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Status
Address
Essentia Health - Jamestown Clinic
Jamestown, North Dakota, 58401
Status
Address
Strecker Cancer Center-Belpre
Belpre, Ohio, 45714
Status
Address
Adena Regional Medical Center
Chillicothe, Ohio, 45601
Status
Address
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
Status
Address
Bethesda North Hospital
Cincinnati, Ohio, 45242
Status
Address
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
Status
Address
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
Status
Address
Mount Carmel East Hospital
Columbus, Ohio, 43213
Status
Address
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
Status
Address
Riverside Methodist Hospital
Columbus, Ohio, 43214
Status
Address
Grant Medical Center
Columbus, Ohio, 43215
Status
Address
The Mark H Zangmeister Center
Columbus, Ohio, 43219
Status
Address
Mount Carmel Health Center West
Columbus, Ohio, 43222
Status
Address
Doctors Hospital
Columbus, Ohio, 43228
Status
Address
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
Status
Address
Grady Memorial Hospital
Delaware, Ohio, 43015
Status
Address
Columbus Oncology and Hematology Associates
Dublin, Ohio, 43016
Status
Address
Dublin Methodist Hospital
Dublin, Ohio, 43016
Status
Address
Central Ohio Breast and Endocrine Surgery
Gahanna, Ohio, 43230
Status
Address
Mount Carmel Grove City Hospital
Grove City, Ohio, 43123
Status
Address
Fairfield Medical Center
Lancaster, Ohio, 43130
Status
Address
Saint Rita's Medical Center
Lima, Ohio, 45801
Status
Address
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903
Status
Address
Marietta Memorial Hospital
Marietta, Ohio, 45750
Status
Address
OhioHealth Marion General Hospital
Marion, Ohio, 43302
Status
Address
Knox Community Hospital
Mount Vernon, Ohio, 43050
Status
Address
Licking Memorial Hospital
Newark, Ohio, 43055
Status
Address
Newark Radiation Oncology
Newark, Ohio, 43055
Status
Address
Mercy Health - Perrysburg Hospital
Perrysburg, Ohio, 43551
Status
Address
Southern Ohio Medical Center
Portsmouth, Ohio, 45662
Status
Address
Mercy Health - Saint Vincent Hospital
Toledo, Ohio, 43608
Status
Address
Mercy Health - Saint Anne Hospital
Toledo, Ohio, 43623
Status
Address
Mercy Health Sylvania Radiation Oncology Center
Toledo, Ohio, 43623
Status
Address
Saint Ann's Hospital
Westerville, Ohio, 43081
Status
Address
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, 43701
Status
Address
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
Status
Address
Saint Charles Health System
Bend, Oregon, 97701
Status
Address
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
Status
Address
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
Status
Address
Bay Area Hospital
Coos Bay, Oregon, 97420
Status
Address
Providence Newberg Medical Center
Newberg, Oregon, 97132
Status
Address
Providence Portland Medical Center
Portland, Oregon, 97213
Status
Address
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
Status
Address
Saint Charles Health System-Redmond
Redmond, Oregon, 97756
Status
Address
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Status
Address
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017
Status
Address
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Status
Address
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
Status
Address
Lehigh Valley Hospital-Hazelton
Hazleton, Pennsylvania, 18201
Status
Address
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
Status
Address
Paoli Memorial Hospital
Paoli, Pennsylvania, 19301
Status
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Status
Address
Lankenau Medical Center
Wynnewood, Pennsylvania, 19096
Status
Address
Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina, 29910
Status
Address
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
Status
Address
Medical University of South Carolina
Charleston, South Carolina, 29425
Status
Address
Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640
Status
Address
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605
Status
Address
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
Status
Address
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605
Status
Address
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
Status
Address
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
Status
Address
South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina, 29926-3827
Status
Address
The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island, South Carolina, 29926
Status
Address
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
Status
Address
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Status
Address
Saint Joseph Regional Cancer Center
Bryan, Texas, 77802
Status
Address
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
Status
Address
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
Status
Address
Saint Michael Cancer Center
Bremerton, Washington, 98310
Status
Address
Highline Medical Center-Main Campus
Burien, Washington, 98166
Status
Address
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
Status
Address
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
Status
Address
Saint Elizabeth Hospital
Enumclaw, Washington, 98022
Status
Address
Providence Regional Cancer Partnership
Everett, Washington, 98201
Status
Address
Saint Francis Hospital
Federal Way, Washington, 98003
Status
Address
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
Status
Address
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
Status
Address
Saint Clare Hospital
Lakewood, Washington, 98499
Status
Address
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
Status
Address
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
Status
Address
Swedish Medical Center-First Hill
Seattle, Washington, 98122-4307
Status
Address
Swedish Medical Center-Cherry Hill
Seattle, Washington, 98122-5711
Status
Address
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
Status
Address
Providence Regional Cancer System-Shelton
Shelton, Washington, 98584
Status
Address
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
Status
Address
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
Status
Address
Providence Regional Cancer System-Yelm
Yelm, Washington, 98597
Status
Address
Aspirus Langlade Hospital
Antigo, Wisconsin, 54409
Status
Address
Duluth Clinic Ashland
Ashland, Wisconsin, 54806
Status
Address
Northwest Wisconsin Cancer Center
Ashland, Wisconsin, 54806
Status
Address
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, 54729
Status
Address
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
Status
Address
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Address
Marshfield Clinic - Ladysmith Center
Ladysmith, Wisconsin, 54848
Status
Address
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Status
Address
Aspirus Medford Hospital
Medford, Wisconsin, 54451
Status
Address
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
Status
Address
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, 54548
Status
Address
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
Status
Address
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
Status
Address
Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin, 54482
Status
Address
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
Status
Address
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, 54401
Status
Address
Diagnostic and Treatment Center
Weston, Wisconsin, 54476
Status
Address
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
Status
Address
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, 54494
Status
Address
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, 54494
International Sites
Status
Address
FHP Health Center-Guam
Tamuning, , 96913
