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Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

Study Purpose

This phase II trial studies how well veliparib, radiation therapy, and temozolomide work in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations. Poly adenosine diphosphate (ADP) ribose polymerases (PARPs) are proteins that help repair DNA mutations. PARP inhibitors, such as veliparib, can keep PARP from working, so tumor cells can't repair themselves, and they may stop growing. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving veliparib, radiation therapy, and temozolomide may work better in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations compared to radiation therapy and temozolomide alone.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 3 Years - 25 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Stratum 1 (IDH wild-type): Patients must be >= 3 years of age and =< 21 years of age at the time of enrollment - Stratum 2 (IDH mutant): Patients must be >= 3 years of age and =< 25 years of age at the time of enrollment - Patients must have eligibility confirmed by rapid central pathology and central molecular screening reviews performed on APEC14B1: - Newly-diagnosed high-grade glioma such as anaplastic astrocytoma or glioblastoma - Negative results for H3 K27M by immunohistochemistry (IHC) - Negative results for BRAFV600 mutation by next-generation sequencing (NGS) - Patients must have histological verification of diagnosis.
Patients with M+ disease (defined as evidence of neuraxis dissemination) are not eligible. Cerebrospinal fluid (CSF) cytology is not required but may be obtained if clinically indicated prior to study enrollment. If cytology is positive, the patient would be considered to have metastatic disease and would, therefore, be ineligible
  • - Pre-operative and post-operative brain magnetic resonance imaging (MRI) with and without contrast must be obtained.
The requirement for a post-operative MRI is waived for patients who undergo biopsy only. A spine MRI is not required, but may be obtained if clinically indicated. If the spine MRI is positive, the patient would be considered to have M+ disease (defined as neuraxis dissemination) and would be ineligible
  • - Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2.
Use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age
  • - Peripheral absolute neutrophil count (ANC) >= 1,000/uL (within 7 days prior to enrollment) - Platelet count >= 100,000/uL (transfusion independent) (within 7 days prior to enrollment) - Hemoglobin >= 8.0 gm/dL (can be transfused) (within 7 days prior to enrollment) - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows (within 7 days prior to enrollment): - 3 to < 6 years: 0.8 (male and female) maximum serum creatinine (mg/dL) - 6 to < 10 years: 1 (male and female) maximum serum creatinine (mg/dL) - 10 to < 13 years: 1.2 (male and female) maximum serum creatinine (mg/dL) - 13 to < 16 years: 1.5 (male), 1.4 (female) maximum serum creatinine (mg/dL) - >= 16 years: 1.7 (male), 1.4 (female) maximum serum creatinine (mg/dL) - Total bilirubin =< 1.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment) - Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment) - Patients with seizure disorder may be enrolled if seizures are well-controlled (i.e., patients must not have required rescue medications for uncontrolled seizures within 14 days prior to enrollment) - Patients must be enrolled and protocol therapy must be projected to begin no later than 31 days after definitive diagnostic surgery (Day 0) - All patients and/or their parents or legal guardians must sign a written informed consent - All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

    Exclusion Criteria:

    - Patients with the following histologies: - Diffuse astrocytoma (grade 2) - Oligodendrogliomas (any grade) - Pleomorphic xanthoastrocytoma (PXA, any grade) - Patients with primary tumor location of brainstem or spinal cord - Patients with M+ disease (defined as neuraxis dissemination either by imaging or by cytology) - Patients with treatment-related acute myeloid leukemia (AML) (t-AML)/myelodysplastic syndrome (MDS) or with features suggestive of AML/MDS - Prior allogenic bone marrow transplant or double umbilical cord blood transplantation - Patients must not have received any prior tumor-directed therapy including radiation therapy, chemotherapy (tumor-directed therapy), molecularly targeted agents, or immunotherapy for the treatment of HGG other than surgical intervention and/or corticosteroids - Lumbar CSF cytology is not required, but may be performed if clinically indicated prior to study enrollment.
If lumbar CSF cytology is positive, the patient is considered to have M+ disease and is ineligible - Note: False positive cytology can occur within 10 days of surgery - Patients with gliomatosis cerebri type 1 or 2 - Patients who are not able to receive protocol specified radiation therapy - Patients must not be currently receiving other anti-cancer agents - Patients with known constitutional mismatch repair deficiency syndrome (CMMR-D)/biallelic mismatch repair deficiency (bMMRD) - Female patients who are pregnant are ineligible due to risks of fetal and teratogenic adverse events as seen in animal/human studies - Lactating females are not eligible unless they have agreed not to breastfeed their infants - Female patients of childbearing potential are not eligible unless a negative pregnancy test result has been obtained - Sexually active patients of reproductive potential are not eligible unless they have agreed to use an effective contraceptive method for the duration of their study participation and for 6 months after the last dose of protocol-specified chemotherapy

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03581292
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

National Cancer Institute (NCI)
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Matthias A Karajannis
Principal Investigator Affiliation Children's Oncology Group
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

NIH
Overall Status Recruiting
Countries Australia, Canada, New Zealand, Puerto Rico, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Anaplastic Astrocytoma, Glioblastoma, Malignant Glioma
Additional Details

PRIMARY OBJECTIVES:

  • I. To determine whether veliparib (ABT-888), when added to radiotherapy (RT) and temozolomide, is efficacious for the treatment of patients with newly-diagnosed high-grade glioma (HGG) whose tumors' molecular profile are wild-type for H3 K27M, BRAF, and IDH1/2.
  • II. To determine whether veliparib (ABT-888), when added to RT and temozolomide, is efficacious for the treatment of patients with newly-diagnosed HGG whose tumors' molecular profile are wild-type for H3 K27M and BRAF and harbor an IDH1/2 mutation.
EXPLORATORY OBJECTIVES:
  • I. To explore associations of genomic, transcriptomic, and/or epigenetic alterations of the tumors with treatment response and outcome.
  • II. To explore the extent to which patients with BRCA1/2 gene alterations and other deoxyribonucleic acid (DNA) damaged genes display tumor genomic features consistent with homologous repair deficiency (HRD), including large scale state transitions (LSTs), mutational signature 3, and an enrichment for deletions flanked by sequences of (micro) homology.
  • III. To explore the burden of high, moderate, and low penetrant germline alterations in HRD genes (such as BRCA1, BRCA2, PALB2, Fanconi complex genes, ATM, CHEK2, RAD51B/C/D), mis-match repair genes (such as MLH1, MSH2, MSH6, PMS2, EPCAM), and energy metabolism genes (such as SDHA, SDHB, SDHC, SDHAF2, SDHD, IDH1, IDH2, and FH).
  • IV. To explore constitutional imprinting abnormalities associated with EP300 and IGF2 in peripheral blood from patients with HGGs.
OUTLINE: CHEMORADIOTHERAPY PHASE: Patients receive veliparib orally (PO) twice daily (BID) and undergo 30 daily fractions of radiation therapy 5 days per week for 6-7 weeks in the absence of disease progression or unacceptable toxicity. MAINTENANCE CHEMOTHERAPY: Beginning 4 weeks after chemoradiotherapy phase, patients receive veliparib PO BID and temozolomide PO once daily (QD) on days 1-5. Treatment repeats every 28 days for up to 10 cycles in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 3 months for year 1, every 4 months for year 2, every 6 months for year 3, and then once yearly for years 4-10.

Arms & Interventions

Arms

Experimental: Treatment (veliparib, radiation therapy, temozolomide)

CHEMORADIOTHERAPY PHASE: Patients receive veliparib PO BID and undergo 30 daily fractions of radiation therapy 5 days per week for 6-7 weeks in the absence of disease progression or unacceptable toxicity. MAINTENANCE CHEMOTHERAPY: Beginning 4 weeks after chemoradiotherapy phase, patients receive veliparib PO BID and temozolomide PO QD on days 1-5. Treatment repeats every 28 days for up to 10 cycles in the absence of disease progression or unacceptable toxicity.

Interventions

Radiation: - Radiation Therapy

Undergo radiation therapy

Drug: - Temozolomide

Given PO

Drug: - Veliparib

Given PO

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Children's Hospital of Alabama, Birmingham, Alabama

Status

Recruiting

Address

Children's Hospital of Alabama

Birmingham, Alabama, 35233

Site Contact

Site Public Contact

oncologyresearch@peds.uab.edu

205-638-9285

USA Health Strada Patient Care Center, Mobile, Alabama

Status

Recruiting

Address

USA Health Strada Patient Care Center

Mobile, Alabama, 36604

Site Contact

Site Public Contact

800-388-8721

Banner Children's at Desert, Mesa, Arizona

Status

Recruiting

Address

Banner Children's at Desert

Mesa, Arizona, 85202

Site Contact

Site Public Contact

480-412-3100

Phoenix Childrens Hospital, Phoenix, Arizona

Status

Recruiting

Address

Phoenix Childrens Hospital

Phoenix, Arizona, 85016

Site Contact

Site Public Contact

602-546-0920

Arkansas Children's Hospital, Little Rock, Arkansas

Status

Recruiting

Address

Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3591

Site Contact

Site Public Contact

501-364-7373

Kaiser Permanente Downey Medical Center, Downey, California

Status

Recruiting

Address

Kaiser Permanente Downey Medical Center

Downey, California, 90242

Site Contact

Site Public Contact

626-564-3455

Loma Linda University Medical Center, Loma Linda, California

Status

Recruiting

Address

Loma Linda University Medical Center

Loma Linda, California, 92354

Site Contact

Site Public Contact

909-558-3375

Long Beach, California

Status

Recruiting

Address

Miller Children's and Women's Hospital Long Beach

Long Beach, California, 90806

Site Contact

Site Public Contact

562-933-5600

Children's Hospital Los Angeles, Los Angeles, California

Status

Recruiting

Address

Children's Hospital Los Angeles

Los Angeles, California, 90027

Site Contact

Site Public Contact

323-361-4110

Cedars Sinai Medical Center, Los Angeles, California

Status

Recruiting

Address

Cedars Sinai Medical Center

Los Angeles, California, 90048

Site Contact

Site Public Contact

310-423-8965

Mattel Children's Hospital UCLA, Los Angeles, California

Status

Recruiting

Address

Mattel Children's Hospital UCLA

Los Angeles, California, 90095

Site Contact

Site Public Contact

310-825-6708

Valley Children's Hospital, Madera, California

Status

Recruiting

Address

Valley Children's Hospital

Madera, California, 93636

Site Contact

Site Public Contact

Research@valleychildrens.org

559-353-3000

Oakland, California

Status

Recruiting

Address

Children's Hospital and Research Center at Oakland

Oakland, California, 94609-1809

Site Contact

Site Public Contact

cgolden@mail.cho.org

510-428-3324

Kaiser Permanente-Oakland, Oakland, California

Status

Recruiting

Address

Kaiser Permanente-Oakland

Oakland, California, 94611

Site Contact

Site Public Contact

Kpoct@kp.org

877-642-4691

Children's Hospital of Orange County, Orange, California

Status

Recruiting

Address

Children's Hospital of Orange County

Orange, California, 92868

Site Contact

Site Public Contact

714-997-3000

Palo Alto, California

Status

Recruiting

Address

Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304

Site Contact

Site Public Contact

ccto-office@stanford.edu

800-694-0012

Torrance, California

Status

Recruiting

Address

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, California, 90502

Site Contact

Site Public Contact

irb@lundquist.org

310-222-3624

Children's Hospital Colorado, Aurora, Colorado

Status

Recruiting

Address

Children's Hospital Colorado

Aurora, Colorado, 80045

Site Contact

Site Public Contact

josh.b.gordon@nsmtp.kp.org

303-764-5056

Connecticut Children's Medical Center, Hartford, Connecticut

Status

Recruiting

Address

Connecticut Children's Medical Center

Hartford, Connecticut, 06106

Site Contact

Site Public Contact

860-545-9981

Yale University, New Haven, Connecticut

Status

Recruiting

Address

Yale University

New Haven, Connecticut, 06520

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

Alfred I duPont Hospital for Children, Wilmington, Delaware

Status

Recruiting

Address

Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803

Site Contact

Site Public Contact

dperry@nemours.org

302-651-6884

MedStar Georgetown University Hospital, Washington, District of Columbia

Status

Recruiting

Address

MedStar Georgetown University Hospital

Washington, District of Columbia, 20007

Site Contact

Site Public Contact

202-444-2223

Children's National Medical Center, Washington, District of Columbia

Status

Recruiting

Address

Children's National Medical Center

Washington, District of Columbia, 20010

Site Contact

Site Public Contact

202-884-2549

Fort Myers, Florida

Status

Recruiting

Address

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908

Site Contact

Site Public Contact

molly.arnstrom@leehealth.org

239-343-5333

Hollywood, Florida

Status

Recruiting

Address

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, 33021

Site Contact

Site Public Contact

OHR@mhs.net

954-265-1847

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

Status

Recruiting

Address

Nemours Children's Clinic-Jacksonville

Jacksonville, Florida, 32207

Site Contact

Site Public Contact

904-697-3529

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Site Contact

Site Public Contact

305-243-2647

Nicklaus Children's Hospital, Miami, Florida

Status

Recruiting

Address

Nicklaus Children's Hospital

Miami, Florida, 33155

Site Contact

Site Public Contact

888-624-2778

AdventHealth Orlando, Orlando, Florida

Status

Recruiting

Address

AdventHealth Orlando

Orlando, Florida, 32803

Site Contact

Site Public Contact

FH.Cancer.Research@flhosp.org

407-303-2090

Arnold Palmer Hospital for Children, Orlando, Florida

Status

Recruiting

Address

Arnold Palmer Hospital for Children

Orlando, Florida, 32806

Site Contact

Site Public Contact

melissa.leffin@orlandohealth.com

321-843-2584

Nemours Children's Hospital, Orlando, Florida

Status

Recruiting

Address

Nemours Children's Hospital

Orlando, Florida, 32827

Site Contact

Site Public Contact

407-650-7715

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Status

Recruiting

Address

Johns Hopkins All Children's Hospital

Saint Petersburg, Florida, 33701

Site Contact

Site Public Contact

Ashley.Repp@jhmi.edu

727-767-4784

Tampa General Hospital, Tampa, Florida

Status

Recruiting

Address

Tampa General Hospital

Tampa, Florida, 33606

Site Contact

Site Public Contact

syapchanyk@tgh.org

813-844-7829

Tampa, Florida

Status

Recruiting

Address

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607

Site Contact

Site Public Contact

jennifer.manns@baycare.org

813-357-0849

Saint Mary's Hospital, West Palm Beach, Florida

Status

Recruiting

Address

Saint Mary's Hospital

West Palm Beach, Florida, 33407

Site Contact

Site Public Contact

561-881-2815

Atlanta, Georgia

Status

Recruiting

Address

Children's Healthcare of Atlanta - Egleston

Atlanta, Georgia, 30322

Site Contact

Site Public Contact

Leann.Schilling@choa.org

404-785-2025

Savannah, Georgia

Status

Recruiting

Address

Memorial Health University Medical Center

Savannah, Georgia, 31404

Site Contact

Site Public Contact

clayter1@memorialhealth.com

912-350-7887

Honolulu, Hawaii

Status

Recruiting

Address

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826

Site Contact

Site Public Contact

808-983-6090

Boise, Idaho

Status

Recruiting

Address

Saint Luke's Mountain States Tumor Institute

Boise, Idaho, 83712

Site Contact

Site Public Contact

eslinget@slhs.org

208-381-2774

Lurie Children's Hospital-Chicago, Chicago, Illinois

Status

Recruiting

Address

Lurie Children's Hospital-Chicago

Chicago, Illinois, 60611

Site Contact

Site Public Contact

773-880-4562

University of Illinois, Chicago, Illinois

Status

Recruiting

Address

University of Illinois

Chicago, Illinois, 60612

Site Contact

Site Public Contact

312-355-3046

Chicago, Illinois

Status

Recruiting

Address

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

Site Contact

Site Public Contact

cancerclinicaltrials@bsd.uchicago.edu

773-702-8222

Loyola University Medical Center, Maywood, Illinois

Status

Recruiting

Address

Loyola University Medical Center

Maywood, Illinois, 60153

Site Contact

Site Public Contact

708-226-4357

Saint Jude Midwest Affiliate, Peoria, Illinois

Status

Recruiting

Address

Saint Jude Midwest Affiliate

Peoria, Illinois, 61637

Site Contact

Site Public Contact

888-226-4343

Riley Hospital for Children, Indianapolis, Indiana

Status

Recruiting

Address

Riley Hospital for Children

Indianapolis, Indiana, 46202

Site Contact

Site Public Contact

800-248-1199

Indianapolis, Indiana

Status

Recruiting

Address

Saint Vincent Hospital and Health Care Center

Indianapolis, Indiana, 46260

Site Contact

Site Public Contact

research@stvincent.org

317-338-2194

Blank Children's Hospital, Des Moines, Iowa

Status

Recruiting

Address

Blank Children's Hospital

Des Moines, Iowa, 50309

Site Contact

Site Public Contact

samantha.mallory@unitypoint.org

515-241-8912

Iowa City, Iowa

Status

Recruiting

Address

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242

Site Contact

Site Public Contact

800-237-1225

Lexington, Kentucky

Status

Recruiting

Address

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Site Contact

Site Public Contact

859-257-3379

Eastern Maine Medical Center, Bangor, Maine

Status

Recruiting

Address

Eastern Maine Medical Center

Bangor, Maine, 04401

Site Contact

Site Public Contact

207-973-4274

Baltimore, Maryland

Status

Recruiting

Address

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Site Contact

Site Public Contact

jhcccro@jhmi.edu

410-955-8804

Bethesda, Maryland

Status

Recruiting

Address

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600

Site Contact

Site Public Contact

301-319-2100

Boston, Massachusetts

Status

Recruiting

Address

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114

Site Contact

Site Public Contact

877-726-5130

Dana-Farber Cancer Institute, Boston, Massachusetts

Status

Recruiting

Address

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

Site Contact

Site Public Contact

877-442-3324

Worcester, Massachusetts

Status

Recruiting

Address

UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655

Site Contact

Site Public Contact

cancer.research@umassmed.edu

508-856-3216

C S Mott Children's Hospital, Ann Arbor, Michigan

Status

Recruiting

Address

C S Mott Children's Hospital

Ann Arbor, Michigan, 48109

Site Contact

Site Public Contact

800-865-1125

Detroit, Michigan

Status

Recruiting

Address

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

Site Contact

Site Public Contact

ctoadmin@karmanos.org

313-576-9790

Ascension Saint John Hospital, Detroit, Michigan

Status

Recruiting

Address

Ascension Saint John Hospital

Detroit, Michigan, 48236

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

Grand Rapids, Michigan

Status

Recruiting

Address

Helen DeVos Children's Hospital at Spectrum Health

Grand Rapids, Michigan, 49503

Site Contact

Site Public Contact

crcwm-regulatory@crcwm.org

616-391-1230

Bronson Methodist Hospital, Kalamazoo, Michigan

Status

Recruiting

Address

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

Site Contact

Site Public Contact

crcwm-regulatory@crcwm.org

616-391-1230

Beaumont Children's Hospital-Royal Oak, Royal Oak, Michigan

Status

Recruiting

Address

Beaumont Children's Hospital-Royal Oak

Royal Oak, Michigan, 48073

Site Contact

Site Public Contact

248-551-7695

Minneapolis, Minnesota

Status

Recruiting

Address

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404

Site Contact

Site Public Contact

612-813-5193

Minneapolis, Minnesota

Status

Recruiting

Address

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455

Site Contact

Site Public Contact

612-624-2620

Mayo Clinic in Rochester, Rochester, Minnesota

Status

Recruiting

Address

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

Site Contact

Site Public Contact

855-776-0015

University of Mississippi Medical Center, Jackson, Mississippi

Status

Recruiting

Address

University of Mississippi Medical Center

Jackson, Mississippi, 39216

Site Contact

Site Public Contact

601-815-6700

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Status

Recruiting

Address

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108

Site Contact

Site Public Contact

rryan@cmh.edu

816-302-6808

Saint Louis, Missouri

Status

Recruiting

Address

Cardinal Glennon Children's Medical Center

Saint Louis, Missouri, 63104

Site Contact

Site Public Contact

314-268-4000

Washington University School of Medicine, Saint Louis, Missouri

Status

Recruiting

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Site Contact

Site Public Contact

info@siteman.wustl.edu

800-600-3606

Mercy Hospital Saint Louis, Saint Louis, Missouri

Status

Recruiting

Address

Mercy Hospital Saint Louis

Saint Louis, Missouri, 63141

Site Contact

Site Public Contact

314-251-7066

Omaha, Nebraska

Status

Recruiting

Address

Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, 68114

Site Contact

Site Public Contact

402-955-3949

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Site Contact

Site Public Contact

unmcrsa@unmc.edu

402-559-6941

Las Vegas, Nevada

Status

Recruiting

Address

University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102

Site Contact

Site Public Contact

research@sncrf.org

702-384-0013

Sunrise Hospital and Medical Center, Las Vegas, Nevada

Status

Recruiting

Address

Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109

Site Contact

Site Public Contact

research@sncrf.org

702-384-0013

Las Vegas, Nevada

Status

Recruiting

Address

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135

Site Contact

Site Public Contact

research@sncrf.org

702-384-0013

Summerlin Hospital Medical Center, Las Vegas, Nevada

Status

Recruiting

Address

Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144

Site Contact

Site Public Contact

research@sncrf.org

702-384-0013

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Status

Recruiting

Address

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756

Site Contact

Site Public Contact

cancer.research.nurse@dartmouth.edu

800-639-6918

Morristown Medical Center, Morristown, New Jersey

Status

Recruiting

Address

Morristown Medical Center

Morristown, New Jersey, 07960

Site Contact

Site Public Contact

973-971-5900

Saint Peter's University Hospital, New Brunswick, New Jersey

Status

Recruiting

Address

Saint Peter's University Hospital

New Brunswick, New Jersey, 08901

Site Contact

Site Public Contact

kcovert@saintpetersuh.com

732-745-8600 #6163

Albany Medical Center, Albany, New York

Status

Recruiting

Address

Albany Medical Center

Albany, New York, 12208

Site Contact

Site Public Contact

518-262-5513

Montefiore Medical Center - Moses Campus, Bronx, New York

Status

Recruiting

Address

Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

Site Contact

Site Public Contact

aaraiza@montefiore.org

718-379-6866

Roswell Park Cancer Institute, Buffalo, New York

Status

Recruiting

Address

Roswell Park Cancer Institute

Buffalo, New York, 14263

Site Contact

Site Public Contact

askroswell@roswellpark.org

800-767-9355

New York, New York

Status

Recruiting

Address

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016

Site Contact

Site Public Contact

prmc.coordinator@nyumc.org

212-263-4434

New York, New York

Status

Recruiting

Address

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

Site Contact

Site Public Contact

nr2616@cumc.columbia.edu

212-305-6361

Memorial Sloan Kettering Cancer Center, New York, New York

Status

Recruiting

Address

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Site Contact

Site Public Contact

212-639-7592

University of Rochester, Rochester, New York

Status

Recruiting

Address

University of Rochester

Rochester, New York, 14642

Site Contact

Site Public Contact

585-275-5830

Syracuse, New York

Status

Recruiting

Address

State University of New York Upstate Medical University

Syracuse, New York, 13210

Site Contact

Site Public Contact

315-464-5476

Chapel Hill, North Carolina

Status

Recruiting

Address

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599

Site Contact

Site Public Contact

cancerclinicaltrials@med.unc.edu

877-668-0683

Charlotte, North Carolina

Status

Recruiting

Address

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

Site Contact

Site Public Contact

800-804-9376

Duke University Medical Center, Durham, North Carolina

Status

Recruiting

Address

Duke University Medical Center

Durham, North Carolina, 27710

Site Contact

Site Public Contact

888-275-3853

East Carolina University, Greenville, North Carolina

Status

Recruiting

Address

East Carolina University

Greenville, North Carolina, 27834

Site Contact

Site Public Contact

eubankss@ecu.edu

252-744-1015

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Status

Recruiting

Address

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

Site Contact

Site Public Contact

336-713-6771

Sanford Broadway Medical Center, Fargo, North Dakota

Status

Recruiting

Address

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

Akron, Ohio

Status

Recruiting

Address

Children's Hospital Medical Center of Akron

Akron, Ohio, 44308

Site Contact

Site Public Contact

330-543-3193

Cincinnati, Ohio

Status

Recruiting

Address

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229

Site Contact

Site Public Contact

cancer@cchmc.org

513-636-2799

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Status

Recruiting

Address

Rainbow Babies and Childrens Hospital

Cleveland, Ohio, 44106

Site Contact

Site Public Contact

216-844-5437

Cleveland Clinic Foundation, Cleveland, Ohio

Status

Recruiting

Address

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

Site Contact

Site Public Contact

TaussigResearch@ccf.org

866-223-8100

Nationwide Children's Hospital, Columbus, Ohio

Status

Recruiting

Address

Nationwide Children's Hospital

Columbus, Ohio, 43205

Site Contact

Site Public Contact

amy.yekisa@nationwidechildrens.org

614-072-2657

Dayton Children's Hospital, Dayton, Ohio

Status

Recruiting

Address

Dayton Children's Hospital

Dayton, Ohio, 45404

Site Contact

Site Public Contact

800-228-4055

Toledo, Ohio

Status

Recruiting

Address

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606

Site Contact

Site Public Contact

419-824-1842

Oklahoma City, Oklahoma

Status

Recruiting

Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Site Contact

Site Public Contact

ou-clinical-trials@ouhsc.edu

405-271-8777

Legacy Emanuel Children's Hospital, Portland, Oregon

Status

Recruiting

Address

Legacy Emanuel Children's Hospital

Portland, Oregon, 97227

Site Contact

Site Public Contact

503-413-2560

Oregon Health and Science University, Portland, Oregon

Status

Recruiting

Address

Oregon Health and Science University

Portland, Oregon, 97239

Site Contact

Site Public Contact

trials@ohsu.edu

503-494-1080

Geisinger Medical Center, Danville, Pennsylvania

Status

Recruiting

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822

Site Contact

Site Public Contact

HemonCCTrials@geisinger.edu

570-271-5251

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Status

Recruiting

Address

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104

Site Contact

Site Public Contact

CancerTrials@email.chop.edu

267-425-5544

Pittsburgh, Pennsylvania

Status

Recruiting

Address

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224

Site Contact

Site Public Contact

jean.tersak@chp.edu

412-692-8570

Rhode Island Hospital, Providence, Rhode Island

Status

Recruiting

Address

Rhode Island Hospital

Providence, Rhode Island, 02903

Site Contact

Site Public Contact

401-444-1488

Medical University of South Carolina, Charleston, South Carolina

Status

Recruiting

Address

Medical University of South Carolina

Charleston, South Carolina, 29425

Site Contact

Site Public Contact

hcc-clinical-trials@musc.edu

843-792-9321

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

Site Contact

Site Public Contact

OncologyClinicalTrialsSF@SanfordHealth.org

605-312-3320

T C Thompson Children's Hospital, Chattanooga, Tennessee

Status

Recruiting

Address

T C Thompson Children's Hospital

Chattanooga, Tennessee, 37403

Site Contact

Site Public Contact

865-331-1812

East Tennessee Childrens Hospital, Knoxville, Tennessee

Status

Recruiting

Address

East Tennessee Childrens Hospital

Knoxville, Tennessee, 37916

Site Contact

Site Public Contact

865-541-8266

Saint Jude Children's Research Hospital, Memphis, Tennessee

Status

Recruiting

Address

Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105

Site Contact

Site Public Contact

referralinfo@stjude.org

888-226-4343

Nashville, Tennessee

Status

Recruiting

Address

The Children's Hospital at TriStar Centennial

Nashville, Tennessee, 37203

Site Contact

Site Public Contact

615-342-1919

Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

Site Contact

Site Public Contact

800-811-8480

Austin, Texas

Status

Recruiting

Address

Dell Children's Medical Center of Central Texas

Austin, Texas, 78723

Site Contact

Site Public Contact

TXAUS-DL-SFCHemonc.research@ascension.org

512-628-1902

Driscoll Children's Hospital, Corpus Christi, Texas

Status

Recruiting

Address

Driscoll Children's Hospital

Corpus Christi, Texas, 78411

Site Contact

Site Public Contact

Crystal.DeLosSantos@dchstx.org

361-694-5311

Medical City Dallas Hospital, Dallas, Texas

Status

Recruiting

Address

Medical City Dallas Hospital

Dallas, Texas, 75230

Site Contact

Site Public Contact

972-566-5588

Dallas, Texas

Status

Recruiting

Address

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

Site Contact

Site Public Contact

canceranswerline@UTSouthwestern.edu

214-648-7097

Cook Children's Medical Center, Fort Worth, Texas

Status

Recruiting

Address

Cook Children's Medical Center

Fort Worth, Texas, 76104

Site Contact

Site Public Contact

CookChildrensResearch@cookchildrens.org

682-885-2103

Houston, Texas

Status

Recruiting

Address

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030

Site Contact

Site Public Contact

burton@bcm.edu

713-798-1354

M D Anderson Cancer Center, Houston, Texas

Status

Recruiting

Address

M D Anderson Cancer Center

Houston, Texas, 77030

Site Contact

Site Public Contact

askmdanderson@mdanderson.org

877-632-6789

Children's Hospital of San Antonio, San Antonio, Texas

Status

Recruiting

Address

Children's Hospital of San Antonio

San Antonio, Texas, 78207

Site Contact

Site Public Contact

helpdesk@childrensoncologygroup.org

San Antonio, Texas

Status

Recruiting

Address

Methodist Children's Hospital of South Texas

San Antonio, Texas, 78229

Site Contact

Site Public Contact

Vinod.GidvaniDiaz@hcahealthcare.com

210-575-6240

San Antonio, Texas

Status

Recruiting

Address

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

Site Contact

Site Public Contact

phoresearchoffice@uthscsa.edu

210-450-3800

Scott and White Memorial Hospital, Temple, Texas

Status

Recruiting

Address

Scott and White Memorial Hospital

Temple, Texas, 76508

Site Contact

Site Public Contact

254-724-5407

Primary Children's Hospital, Salt Lake City, Utah

Status

Recruiting

Address

Primary Children's Hospital

Salt Lake City, Utah, 84113

Site Contact

Site Public Contact

801-585-5270

Norfolk, Virginia

Status

Recruiting

Address

Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507

Site Contact

Site Public Contact

CCBDCresearch@chkd.org

757-668-7243

Naval Medical Center - Portsmouth, Portsmouth, Virginia

Status

Recruiting

Address

Naval Medical Center - Portsmouth

Portsmouth, Virginia, 23708-2197

Site Contact

Site Public Contact

757-953-5939

Richmond, Virginia

Status

Recruiting

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Site Contact

Site Public Contact

klcampbell@vcu.edu

804-628-1914

Seattle Children's Hospital, Seattle, Washington

Status

Recruiting

Address

Seattle Children's Hospital

Seattle, Washington, 98105

Site Contact

Site Public Contact

866-987-2000

Spokane, Washington

Status

Recruiting

Address

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, Washington, 99204

Site Contact

Site Public Contact

HopeBeginsHere@providence.org

800-228-6618

Tacoma, Washington

Status

Recruiting

Address

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, 98405

Site Contact

Site Public Contact

research@multicare.org

253-403-1461

Madigan Army Medical Center, Tacoma, Washington

Status

Recruiting

Address

Madigan Army Medical Center

Tacoma, Washington, 98431

Site Contact

Site Public Contact

mamcdci@amedd.army.mil

253-968-0129

West Virginia University Healthcare, Morgantown, West Virginia

Status

Recruiting

Address

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Site Contact

Site Public Contact

cancertrialsinfo@hsc.wvu.edu

304-293-7374

Madison, Wisconsin

Status

Recruiting

Address

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792

Site Contact

Site Public Contact

800-622-8922

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Status

Recruiting

Address

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Status

Recruiting

Address

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226

Site Contact

Site Public Contact

MACCCTO@mcw.edu

414-955-4727

International Sites

John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales, Australia

Status

Suspended

Address

John Hunter Children's Hospital

Hunter Regional Mail Centre, New South Wales, 2310

Sydney Children's Hospital, Randwick, New South Wales, Australia

Status

Recruiting

Address

Sydney Children's Hospital

Randwick, New South Wales, 2031

Site Contact

Site Public Contact

(02) 9382-1721

The Children's Hospital at Westmead, Westmead, New South Wales, Australia

Status

Suspended

Address

The Children's Hospital at Westmead

Westmead, New South Wales, 2145

Queensland Children's Hospital, South Brisbane, Queensland, Australia

Status

Recruiting

Address

Queensland Children's Hospital

South Brisbane, Queensland, 4101

Site Contact

Site Public Contact

61 7 3068 1111

Monash Medical Center-Clayton Campus, Clayton, Victoria, Australia

Status

Recruiting

Address

Monash Medical Center-Clayton Campus

Clayton, Victoria, 3168

Site Contact

Site Public Contact

(03) 9928 8111

Royal Children's Hospital, Parkville, Victoria, Australia

Status

Suspended

Address

Royal Children's Hospital

Parkville, Victoria, 3052

Perth Children's Hospital, Perth, Western Australia, Australia

Status

Recruiting

Address

Perth Children's Hospital

Perth, Western Australia, 6009

Site Contact

Site Public Contact

helpdesk@childrensoncologygroup.org

Alberta Children's Hospital, Calgary, Alberta, Canada

Status

Suspended

Address

Alberta Children's Hospital

Calgary, Alberta, T3B 6A8

British Columbia Children's Hospital, Vancouver, British Columbia, Canada

Status

Recruiting

Address

British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4

Site Contact

Site Public Contact

604-875-2345 #6477

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador, Canada

Status

Recruiting

Address

Janeway Child Health Centre

Saint John's, Newfoundland and Labrador, A1B 3V6

Site Contact

Site Public Contact

866-722-1126

IWK Health Centre, Halifax, Nova Scotia, Canada

Status

Recruiting

Address

IWK Health Centre

Halifax, Nova Scotia, B3K 6R8

Site Contact

Site Public Contact

902-470-6767

Hamilton, Ontario, Canada

Status

Recruiting

Address

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Ontario, L8N 3Z5

Site Contact

Site Public Contact

905-521-2100

Montreal, Quebec, Canada

Status

Recruiting

Address

The Montreal Children's Hospital of the MUHC

Montreal, Quebec, H3H 1P3

Site Contact

Site Public Contact

info@thechildren.com

514-412-4445

Montreal, Quebec, Canada

Status

Recruiting

Address

Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, H3T 1C5

Site Contact

Site Public Contact

514-345-4931

Quebec, Canada

Status

Recruiting

Address

Centre Hospitalier Universitaire de Quebec

Quebec, , G1V 4G2

Site Contact

Site Public Contact

418-525-4444

Starship Children's Hospital, Grafton, Auckland, New Zealand

Status

Recruiting

Address

Starship Children's Hospital

Grafton, Auckland, 1145

Site Contact

Site Public Contact

0800 728 436

Christchurch Hospital, Christchurch, New Zealand

Status

Recruiting

Address

Christchurch Hospital

Christchurch, , 8011

Site Contact

Site Public Contact

03 364 0640

HIMA San Pablo Oncologic Hospital, Caguas, Puerto Rico

Status

Recruiting

Address

HIMA San Pablo Oncologic Hospital

Caguas, , 00726

Site Contact

Site Public Contact

787-653-3434