Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations
Study Purpose
This phase II trial studies how well veliparib, radiation therapy, and temozolomide work in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations. Poly adenosine diphosphate (ADP) ribose polymerases (PARPs) are proteins that help repair DNA mutations. PARP inhibitors, such as veliparib, can keep PARP from working, so tumor cells can't repair themselves, and they may stop growing. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving veliparib, radiation therapy, and temozolomide may work better in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations compared to radiation therapy and temozolomide alone.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 3 Years - 25 Years |
| Gender | All |
Inclusion Criteria:
- - Stratum 1 (IDH wild-type): Patients must be >= 3 years of age and =< 21 years of age at the time of enrollment.
- - Please note Stratum 1 was closed to accrual on January 24, 2020.
- - Stratum 2 (IDH mutant): Patients must be >= 3 years of age and =< 25 years of age at the time of enrollment.
- - Patients must have eligibility confirmed by rapid central pathology and central molecular screening reviews performed on APEC14B1: - Newly-diagnosed high-grade glioma such as anaplastic astrocytoma or glioblastoma.
- - Negative results for H3 K27M by immunohistochemistry (IHC) - Negative results for BRAFV600 mutation by next-generation sequencing (NGS) - Patients must have histological verification of diagnosis.
- - Pre-operative and post-operative brain magnetic resonance imaging (MRI) with and without contrast must be obtained.
- - Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2.
- - Peripheral absolute neutrophil count (ANC) >= 1,000/uL (within 7 days prior to enrollment) - Platelet count >= 100,000/uL (transfusion independent) (within 7 days prior to enrollment) - Hemoglobin >= 8.0 gm/dL (can be transfused) (within 7 days prior to enrollment) - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows (within 7 days prior to enrollment): - 3 to < 6 years: 0.8 (male and female) maximum serum creatinine (mg/dL) - 6 to < 10 years: 1 (male and female) maximum serum creatinine (mg/dL) - 10 to < 13 years: 1.2 (male and female) maximum serum creatinine (mg/dL) - 13 to < 16 years: 1.5 (male), 1.4 (female) maximum serum creatinine (mg/dL) - >= 16 years: 1.7 (male), 1.4 (female) maximum serum creatinine (mg/dL) - Total bilirubin =< 1.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment) - Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 135 U/L.
- - Patients with seizure disorder may be enrolled if seizures are well-controlled (i.e., patients must not have required rescue medications for uncontrolled seizures within 14 days prior to enrollment) - Patients must be enrolled and protocol therapy must be projected to begin no later than 31 days after definitive surgery (Day 0).
- - All patients and/or their parents or legal guardians must sign a written informed consent.
- - All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.
Exclusion Criteria:
- - Patients with the following histologies: - Diffuse astrocytoma (grade 2) - Oligodendrogliomas (any grade) - Pleomorphic xanthoastrocytoma (PXA, any grade) - Patients with primary tumor location of brainstem or spinal cord.
- - Patients with M+ disease (defined as neuraxis dissemination either by imaging or by cytology) - Patients with treatment-related acute myeloid leukemia (AML) (t-AML)/myelodysplastic syndrome (MDS) or with features suggestive of AML/MDS.
- - Prior allogenic bone marrow transplant or double umbilical cord blood transplantation.
- - Patients must not have received any prior tumor-directed therapy including radiation therapy, chemotherapy (tumor-directed therapy), molecularly targeted agents, or immunotherapy for the treatment of HGG other than surgical intervention and/or corticosteroids.
- - Lumbar CSF cytology is not required, but may be performed if clinically indicated prior to study enrollment.
- - Note: False positive cytology can occur within 10 days of surgery.
- - Patients with gliomatosis cerebri type 1 or 2.
- - Patients who are not able to receive protocol specified radiation therapy.
- - Patients must not be currently receiving other anti-cancer agents.
- - Patients with known constitutional mismatch repair deficiency syndrome (CMMR-D)/biallelic mismatch repair deficiency (bMMRD) - Female patients who are pregnant are ineligible due to risks of fetal and teratogenic adverse events as seen in animal/human studies.
- - Lactating females are not eligible unless they have agreed not to breastfeed their infants.
- - Female patients of childbearing potential are not eligible unless a negative pregnancy test result has been obtained.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT03581292 |
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Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
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Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Matthias A Karajannis |
| Principal Investigator Affiliation | Children's Oncology Group |
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Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Active, not recruiting |
| Countries | Australia, Canada, New Zealand, Puerto Rico, United States |
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Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Anaplastic Astrocytoma, Glioblastoma, Malignant Glioma |
PRIMARY OBJECTIVES:
- I. To determine whether veliparib (ABT-888), when added to radiotherapy (RT) and temozolomide, is efficacious for the treatment of patients with newly-diagnosed high-grade glioma (HGG) whose tumors' molecular profile are wild-type for H3 K27M, BRAF, and IDH1/2.
- II. To determine whether veliparib (ABT-888), when added to RT and temozolomide, is efficacious for the treatment of patients with newly-diagnosed HGG whose tumors' molecular profile are wild-type for H3 K27M and BRAF and harbor an IDH1/2 mutation.
- I. To explore associations of genomic, transcriptomic, and/or epigenetic alterations of the tumors with treatment response and outcome.
- II. To explore the extent to which patients with BRCA1/2 gene alterations and other deoxyribonucleic acid (DNA) damaged genes display tumor genomic features consistent with homologous repair deficiency (HRD), including large scale state transitions (LSTs), mutational signature 3, and an enrichment for deletions flanked by sequences of (micro) homology.
- III. To explore the burden of high, moderate, and low penetrant germline alterations in HRD genes (such as BRCA1, BRCA2, PALB2, Fanconi complex genes, ATM, CHEK2, RAD51B/C/D), mis-match repair genes (such as MLH1, MSH2, MSH6, PMS2, EPCAM), and energy metabolism genes (such as SDHA, SDHB, SDHC, SDHAF2, SDHD, IDH1, IDH2, and FH).
- IV. To explore constitutional imprinting abnormalities associated with EP300 and IGF2 in peripheral blood from patients with HGGs.
Arms
Experimental: Treatment (radiation therapy, veliparib, temozolomide)
CHEMORADIOTHERAPY PHASE: Patients receive veliparib PO BID and undergo 30 daily fractions of radiation therapy 5 days per week for 6-7 weeks in the absence of disease progression or unacceptable toxicity. MAINTENANCE CHEMOTHERAPY: Beginning 4 weeks after chemoradiotherapy phase, patients receive veliparib PO BID and temozolomide PO QD on days 1-5. Treatment repeats every 28 days for up to 10 cycles in the absence of disease progression or unacceptable toxicity.
Interventions
Radiation: - Radiation Therapy
Undergo radiation therapy
Drug: - Temozolomide
Given PO
Drug: - Veliparib
Given PO
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Children's Hospital of Alabama
Birmingham 4049979, Alabama 4829764, 35233
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USA Health Strada Patient Care Center
Mobile 4076598, Alabama 4829764, 36604
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Banner Children's at Desert
Mesa 5304391, Arizona 5551752, 85202
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Address
Phoenix Childrens Hospital
Phoenix 5308655, Arizona 5551752, 85016
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Address
Arkansas Children's Hospital
Little Rock 4119403, Arkansas 4099753, 72202-3591
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Address
Kaiser Permanente Downey Medical Center
Downey 5343858, California 5332921, 90242
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Address
Loma Linda University Medical Center
Loma Linda 5367696, California 5332921, 92354
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Address
Miller Children's and Women's Hospital Long Beach
Long Beach 5367929, California 5332921, 90806
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Address
Children's Hospital Los Angeles
Los Angeles 5368361, California 5332921, 90027
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Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921, 90048
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Address
Mattel Children's Hospital UCLA
Los Angeles 5368361, California 5332921, 90095
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Address
Valley Children's Hospital
Madera 5369568, California 5332921, 93636
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Address
UCSF Benioff Children's Hospital Oakland
Oakland 5378538, California 5332921, 94609
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Address
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921, 94611
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Address
Children's Hospital of Orange County
Orange 5379513, California 5332921, 92868
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Address
Lucile Packard Children's Hospital Stanford University
Palo Alto 5380748, California 5332921, 94304
Status
Address
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance 5403022, California 5332921, 90502
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Address
Children's Hospital Colorado
Aurora 5412347, Colorado 5417618, 80045
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Address
Connecticut Children's Medical Center
Hartford 4835797, Connecticut 4831725, 06106
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Address
Yale University
New Haven 4839366, Connecticut 4831725, 06520
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Address
Alfred I duPont Hospital for Children
Wilmington 4145381, Delaware 4142224, 19803
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Address
MedStar Georgetown University Hospital
Washington D.C. 4140963, District of Columbia 4138106, 20007
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Address
Children's National Medical Center
Washington D.C. 4140963, District of Columbia 4138106, 20010
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Address
Golisano Children's Hospital of Southwest Florida
Fort Myers 4155995, Florida 4155751, 33908
Status
Address
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood 4158928, Florida 4155751, 33021
Status
Address
Nemours Children's Clinic-Jacksonville
Jacksonville 4160021, Florida 4155751, 32207
Status
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751, 33136
Status
Address
Nicklaus Children's Hospital
Miami 4164138, Florida 4155751, 33155
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Address
AdventHealth Orlando
Orlando 4167147, Florida 4155751, 32803
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Address
Arnold Palmer Hospital for Children
Orlando 4167147, Florida 4155751, 32806
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Address
Nemours Children's Hospital
Orlando 4167147, Florida 4155751, 32827
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Address
Johns Hopkins All Children's Hospital
St. Petersburg 4171563, Florida 4155751, 33701
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Address
Tampa General Hospital
Tampa 4174757, Florida 4155751, 33606
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Address
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751, 33607
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Address
Saint Mary's Medical Center
West Palm Beach 4177887, Florida 4155751, 33407
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Address
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta 4180439, Georgia 4197000, 30329
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Address
Memorial Health University Medical Center
Savannah 4221552, Georgia 4197000, 31404
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Address
Kapiolani Medical Center for Women and Children
Honolulu 5856195, Hawaii 5855797, 96826
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Address
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512, 83712
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Address
Lurie Children's Hospital-Chicago
Chicago 4887398, Illinois 4896861, 60611
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Address
University of Illinois
Chicago 4887398, Illinois 4896861, 60612
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Address
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861, 60637
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Address
Loyola University Medical Center
Maywood 4901514, Illinois 4896861, 60153
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Address
Saint Jude Midwest Affiliate
Peoria 4905687, Illinois 4896861, 61637
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Address
Riley Hospital for Children
Indianapolis 4259418, Indiana 4921868, 46202
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Address
Ascension Saint Vincent Indianapolis Hospital
Indianapolis 4259418, Indiana 4921868, 46260
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Address
Blank Children's Hospital
Des Moines 4853828, Iowa 4862182, 50309
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Address
University of Iowa/Holden Comprehensive Cancer Center
Iowa City 4862034, Iowa 4862182, 52242
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Address
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925, 40536
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Address
Norton Children's Hospital
Louisville 4299276, Kentucky 6254925, 40202
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Address
Children's Hospital New Orleans
New Orleans 4335045, Louisiana 4331987, 70118
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Address
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987, 70121
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Address
Eastern Maine Medical Center
Bangor 4957280, Maine 4971068, 04401
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Address
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885, 21287
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Address
Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885, 20889-5600
Status
Address
Massachusetts General Hospital Cancer Center
Boston 4930956, Massachusetts 6254926, 02114
Status
Address
Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926, 02215
Status
Address
UMass Memorial Medical Center - University Campus
Worcester 4956184, Massachusetts 6254926, 01655
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Address
C S Mott Children's Hospital
Ann Arbor 4984247, Michigan 5001836, 48109
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Address
Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836, 48201
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Address
Henry Ford Health Saint John Hospital
Detroit 4990729, Michigan 5001836, 48236
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Address
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
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Address
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836, 49007
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Address
Corewell Health Children's
Royal Oak 5007804, Michigan 5001836, 48073
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Address
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis 5037649, Minnesota 5037779, 55404
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Address
University of Minnesota/Masonic Cancer Center
Minneapolis 5037649, Minnesota 5037779, 55455
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Address
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779, 55905
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Address
University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296, 39216
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Address
Children's Mercy Hospitals and Clinics
Kansas City 4393217, Missouri 4398678, 64108
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Address
Cardinal Glennon Children's Medical Center
St Louis 4407066, Missouri 4398678, 63104
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Address
Washington University School of Medicine
St Louis 4407066, Missouri 4398678, 63110
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Address
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678, 63141
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Address
Children's Hospital and Medical Center of Omaha
Omaha 5074472, Nebraska 5073708, 68114
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Address
University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708, 68198
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Address
University Medical Center of Southern Nevada
Las Vegas 5506956, Nevada 5509151, 89102
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Address
Sunrise Hospital and Medical Center
Las Vegas 5506956, Nevada 5509151, 89109
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Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas 5506956, Nevada 5509151, 89135
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Address
Summerlin Hospital Medical Center
Las Vegas 5506956, Nevada 5509151, 89144
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Address
Renown Regional Medical Center
Reno 5511077, Nevada 5509151, 89502
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Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174, 03756
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Address
Morristown Medical Center
Morristown 5101427, New Jersey 5101760, 07960
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Address
Saint Peter's University Hospital
New Brunswick 5101717, New Jersey 5101760, 08901
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Address
Albany Medical Center
Albany 5106834, New York 5128638, 12208
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Address
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638, 14263
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Address
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638, 10016
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Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638, 10032
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Address
Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638, 10065
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Address
University of Rochester
Rochester 5134086, New York 5128638, 14642
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Address
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638, 13210
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Address
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638, 10467
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Address
New York Medical College
Valhalla 5142090, New York 5128638, 10595
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Address
Mission Hospital
Asheville 4453066, North Carolina 4482348, 28801
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Address
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348, 27599
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Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348, 28203
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Address
Duke University Medical Center
Durham 4464368, North Carolina 4482348, 27710
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Address
East Carolina University
Greenville 4469160, North Carolina 4482348, 27834
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Address
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348, 27157
Status
Address
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763, 58122
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Address
Children's Hospital Medical Center of Akron
Akron 5145476, Ohio 5165418, 44308
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Address
Cincinnati Children's Hospital Medical Center
Cincinnati 4508722, Ohio 5165418, 45229
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Address
Rainbow Babies and Childrens Hospital
Cleveland 5150529, Ohio 5165418, 44106
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Address
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418, 44195
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Address
Nationwide Children's Hospital
Columbus 4509177, Ohio 5165418, 43205
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Address
Dayton Children's Hospital
Dayton 4509884, Ohio 5165418, 45404
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Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418, 43606
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Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
Status
Address
Legacy Emanuel Children's Hospital
Portland 5746545, Oregon 5744337, 97227
Status
Address
Oregon Health and Science University
Portland 5746545, Oregon 5744337, 97239
Status
Address
Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927, 18103
Status
Address
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927, 17822
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Address
Children's Hospital of Philadelphia
Philadelphia 4560349, Pennsylvania 6254927, 19104
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Address
Children's Hospital of Pittsburgh of UPMC
Pittsburgh 5206379, Pennsylvania 6254927, 15224
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Address
Rhode Island Hospital
Providence 5224151, Rhode Island 5224323, 02903
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Address
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040, 29425
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Address
Prisma Health Richland Hospital
Columbia 4575352, South Carolina 4597040, 29203
Status
Address
BI-LO Charities Children's Cancer Center
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223, 57117-5134
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Address
T C Thompson Children's Hospital
Chattanooga 4612862, Tennessee 4662168, 37403
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Address
East Tennessee Childrens Hospital
Knoxville 4634946, Tennessee 4662168, 37916
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Address
Saint Jude Children's Research Hospital
Memphis 4641239, Tennessee 4662168, 38105
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Address
The Children's Hospital at TriStar Centennial
Nashville 4644585, Tennessee 4662168, 37203
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Address
Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168, 37232
Status
Address
Dell Children's Medical Center of Central Texas
Austin 4671654, Texas 4736286, 78723
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Address
Driscoll Children's Hospital
Corpus Christi 4683416, Texas 4736286, 78411
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Address
Medical City Dallas Hospital
Dallas 4684888, Texas 4736286, 75230
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Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286, 75390
Status
Address
Cook Children's Medical Center
Fort Worth 4691930, Texas 4736286, 76104
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Address
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286, 77030
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Address
M D Anderson Cancer Center
Houston 4699066, Texas 4736286, 77030
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Address
Children's Hospital of San Antonio
San Antonio 4726206, Texas 4736286, 78207
Status
Address
Methodist Children's Hospital of South Texas
San Antonio 4726206, Texas 4736286, 78229
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Address
University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286, 78229
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Address
Scott and White Memorial Hospital
Temple 4735966, Texas 4736286, 76508
Status
Address
Primary Children's Hospital
Salt Lake City 5780993, Utah 5549030, 84113
Status
Address
Children's Hospital of The King's Daughters
Norfolk 4776222, Virginia 6254928, 23507
Status
Address
Naval Medical Center - Portsmouth
Portsmouth 4779999, Virginia 6254928, 23708-2197
Status
Address
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928, 23298
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Address
Seattle Children's Hospital
Seattle 5809844, Washington 5815135, 98105
Status
Address
Providence Sacred Heart Medical Center and Children's Hospital
Spokane 5811696, Washington 5815135, 99204
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Address
Mary Bridge Children's Hospital and Health Center
Tacoma 5812944, Washington 5815135, 98405
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Address
Madigan Army Medical Center
Tacoma 5812944, Washington 5815135, 98431
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Address
West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850, 26506
Status
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468, 53792
Status
Address
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468, 54449
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Address
Children's Hospital of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
International Sites
Status
Address
John Hunter Children's Hospital
Hunter Regional Mail Centre, New South Wales 2155400, 2310
Status
Address
Sydney Children's Hospital
Randwick 2208285, New South Wales 2155400, 2031
Status
Address
The Children's Hospital at Westmead
Westmead 2143973, New South Wales 2155400, 2145
Status
Address
Queensland Children's Hospital
South Brisbane 2207259, Queensland 2152274, 4101
Status
Address
Monash Medical Center-Clayton Campus
Clayton 2171400, Victoria 2145234, 3168
Status
Address
Royal Children's Hospital
Parkville 2153770, Victoria 2145234, 3052
Status
Address
Perth Children's Hospital
Perth 2063523, Western Australia 2058645, 6009
Status
Address
Alberta Children's Hospital
Calgary 5913490, Alberta 5883102, T3B 6A8
Status
Address
British Columbia Children's Hospital
Vancouver 6173331, British Columbia 5909050, V6H 3V4
Status
Address
Janeway Child Health Centre
St. John's 6324733, Newfoundland and Labrador 6354959, A1B 3V6
Status
Address
IWK Health Centre
Halifax 6324729, Nova Scotia 6091530, B3K 6R8
Status
Address
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton 5969782, Ontario 6093943, L8N 3Z5
Status
Address
The Montreal Children's Hospital of the MUHC
Montreal 6077243, Quebec 6115047, H3H 1P3
Status
Address
Centre Hospitalier Universitaire Sainte-Justine
Montreal 6077243, Quebec 6115047, H3T 1C5
Status
Address
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec 6325494, , G1V 4G2
Status
Address
Starship Children's Hospital
Grafton 6232401, Auckland 2193734, 1145
Status
Address
Christchurch Hospital
Christchurch 2192362, , 8011
Status
Address
HIMA San Pablo Oncologic Hospital
Caguas 4563008, , 00726
