cropped color_logo_with_background.png

Molecular Genetic, Host-derived and Clinical Determinants of Long-term Survival in Glioblastoma

Study Purpose

This pro

  • - and retrospective multicenter clinical epidemiological study studies the molecular genetic, host-derived and clinical determinants of glioblastoma patients with an overall survival of more than 5 years.
The different research focusses are: - Identification of clinical parameters and patient characteristics / host-related factors in long-term survivors (Focus 1) - Identification of molecular tumor characteristics in long-term survivors (Focus 2) - Assessment of therapy-related parameters, including neuro-toxicity (Focus 3) - Immunological studies (Focus 4)

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Observational
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Age > 18 years at diagnosis.
  • - Histopathological diagnosis of glioblastoma (reference histology available) and.
  • - Survival >5 years from diagnosis.
  • - Availability of tumor tissue from initial glioblastoma diagnosis (FFPE or fresh-frozen) to validate the diagnosis centrally.
  • - Signed consent form (living patients) or ethics approval for anonymous data collection in case of retrospective analysis of deceased patients.

Exclusion Criteria:

- Not applicable

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03770468
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

European Organisation for Research and Treatment of Cancer - EORTC
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Michael Weller
Principal Investigator Affiliation EORTC Study Coordinator
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Completed
Countries Austria, Belgium, France, Germany, Greece, Italy, Netherlands, Switzerland, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Glioblastoma

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Boston, Massachusetts

Status

Address

Dana-Farber Cancer Institute & Harvard Medical School

Boston, Massachusetts, 02115-5450

International Sites

Vienna, Austria

Status

Address

Universitaetsklinikum Wien - AKH uniklinieken

Vienna, , 1090

Hopitaux Universitaires Bordet-Erasme, Brussel, Belgium

Status

Address

Hopitaux Universitaires Bordet-Erasme

Brussel, , 1070

Bron, France

Status

Address

CHU Lyon - Hopital neurologique Pierre Wertheimer

Bron, , 69677

CHRU de Lille, Lille, France

Status

Address

CHRU de Lille

Lille, ,

Marseille, France

Status

Address

Hopitaux de Marseille - Hôpital de La Timone (APHM)

Marseille, , 13385

Institut du Cancer de Montpellier, Montpellier, France

Status

Address

Institut du Cancer de Montpellier

Montpellier, , 34298

CHU de Nice - Hopital Pasteur, Nice, France

Status

Address

CHU de Nice - Hopital Pasteur

Nice, , 6000

Hopitaux de Paris - Hopital Saint-Louis, Paris, France

Status

Address

Hopitaux de Paris - Hopital Saint-Louis

Paris, , 75475

Hopitaux de Paris - La Pitie Salpetriere, Paris, France

Status

Address

Hopitaux de Paris - La Pitie Salpetriere

Paris, , 75651

CHU d'Amiens - CHU Amiens - Hopital Sud, Salouël, France

Status

Address

CHU d'Amiens - CHU Amiens - Hopital Sud

Salouël, , 80480

Universitaetsklinikum Bonn, Bonn, Germany

Status

Address

Universitaetsklinikum Bonn

Bonn, , 53105

Universitaetsklinikum Carl Gustav Carus, Dresden, Germany

Status

Address

Universitaetsklinikum Carl Gustav Carus

Dresden, , 01307

Universitaetsklinikum - Essen, Essen, Germany

Status

Address

Universitaetsklinikum - Essen

Essen, , 45147

Ronellenfitsch Michael, Frankfurt, Germany

Status

Address

Ronellenfitsch Michael

Frankfurt, , 60528

Universitaetsklinikum Freiburg, Freiburg, Germany

Status

Address

Universitaetsklinikum Freiburg

Freiburg, , 79106

UniversitaetsKlinikum Heidelberg, Heidelberg, Germany

Status

Address

UniversitaetsKlinikum Heidelberg

Heidelberg, , 69120

Muenchen, Germany

Status

Address

Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern

Muenchen, , 81377

Muenchen, Germany

Status

Address

Technische Universitaet Muenchen - Klinikum Rechts Der Isar

Muenchen, , 81675

Universitaetsklinikum Regensburg, Regensburg, Germany

Status

Address

Universitaetsklinikum Regensburg

Regensburg, , 93053

Hygeia Hospital, Athens, Greece

Status

Address

Hygeia Hospital

Athens, , 151 23

Padova, Italy

Status

Address

Azienda Ospedaliera Di Padova - Istituto Oncologico Veneto IRCCS

Padova, , 35128

Torino, Italy

Status

Address

Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni

Torino, , 10126

Amsterdam UMC - locatie VUmc, Amsterdam, Netherlands

Status

Address

Amsterdam UMC - locatie VUmc

Amsterdam, , 1081HV

Erasmus MC, Rotterdam, Netherlands

Status

Address

Erasmus MC

Rotterdam, , 3015 GD

Lausanne, Switzerland

Status

Address

Centre Hospitalier Universitaire Vaudois - Lausanne

Lausanne, , 1011

Univ. Spital Zurich, Zürich, Switzerland

Status

Address

Univ. Spital Zurich

Zürich, , 8091