Inclusion Criteria:
- - Adult patients ≥ 18 years of age with one or more brain tumors planned for
neurosurgical resection/biopsy.
- - Pathologically-documented glioblastoma; or.
- - Metastatic cancer that:
o Has a history of Her2 expression or activating Her2-mutation.
- - Her2+ defined as 3+ on IHC.
- - Her2-low defined as IHC1+ or 2+ and ISH- according to ASCO-CAP 2018 Her2 testing
guidelines52.
- - Her2 mutations must be described to be activating, occur at a known hotspot (e.g. exon
20 insertions, S310, G660, R678, L755, D769, L777), or involve the transmembrane,
juxtamembrane or tyrosine kinase domains.
- - Other untreated brain tumors (and prior radiation, including whole-brain and/or
stereotactic radiation) are allowed.
- - Patients with concomitant leptomeningeal metastasis are eligible provided they have
parenchymal brain neoplastic disease requiring resection/biopsy.
- - Prior treatments:
- Cohort A: Brain parenchymal metastases in patients with Her2-expressing/ERBB2-
activating-mutant cancer with no prior T-DXd exposure (T-DXd naïve)
- Cohort B: Brain parenchymal metastases in patients with Her2-expressing/ERBB2-
activating-mutant cancer with prior T-DXd exposure.
- - Cohort C: Recurrent glioblastoma.
- - For all cohorts: no limit on prior CNS radiation or systemic therapy, including
Her2- targeting antibody therapy (including trastuzumab, pertuzumab, trastuzumab
emtansine)
- KPS ≥ 60 Or ECOG < 2.
- - Life expectancy >12 weeks.
- - Left ventricular ejection fraction ≥50%
- Adequate bone marrow, renal, hepatic, and coagulation parameters (obtained ≤7 days
prior to the first day of study treatment):
- Absolute neutrophil count (ANC) ≥1.5 × 103/μL (granulocyte-colony stimulating
factor administration is not allowed within 1 week prior to C1D1)
- Platelet count ≥10.0x104/μL.
Note: Participants requiring ongoing transfusions or
growth factor support to maintain platelet count ≥10.0x104/μL are not eligible.
(Platelet transfusion is not allowed within 1 week prior to C1D1)
Note: Participants requiring ongoing transfusions or
growth factor support to maintain hemoglobin ≥8.0 g/dL are not eligible (> 8 g/dL
in gastric cancer / gastroesophageal cancer indications). (Red blood cell
transfusion is not allowed within 1 week prior to C1D1)
- - Serum albumin ≥ 2.5 g/dL.
- - Creatinine clearance ≥30 mL/min, as calculated using the Cockcroft-Gault equation.
- - Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤3 × upper
limit of normal (ULN) (<5x ULN in participants with liver metastases)
- Total bilirubin ≤1.5 × ULN) if no liver metastases or <3 × ULN in the presence of
documented Gilbert's syndrome (unconjugated hyperbilirubinemia) or liver
metastases at baseline.
- - International normalized ratio (INR) and activated partial thromboplastin time
(aPTT) ≤1.0xULN unless on medication known to reversibly alter INR and/or aPTT.
- - Evidence of post-menopausal status or negative serum pregnancy test for females of
childbearing potential who are sexually active with a non-sterilized male partner.
For
women of childbearing potential, a negative result for serum pregnancy test (test must
have a sensitivity of at least 25 mIU/mL) must be available within 7 days of the
screening visit and urine beta-human chorionic gonadotropin (β-HCG) pregnancy test
prior to each administration of T-DXd.
- - Women of childbearing potential are defined as those who are not surgically sterile
(i.e.
underwent bilateral salpingectomy, bilateral oophorectomy, or complete hysterectomy).
Women
will be considered post-menopausal if they have been amenorrheic for 12 months without an
alternative medical cause.
- - Female patients of childbearing potential who are sexually active with a
non-sterilized male partner must use at least one highly effective method of
contraception, presented in Table 1 from the time of screening and must agree to
continue using such precautions for 7 months after the last dose of T-DXd.
Note:
estrogen/progesterone is contraindicated in ER+ breast cancer, and in other cancers
could increase the risk of DVT. Female patients must refrain from breastfeeding while
on study and for 7 months after the last dose of T-DXd.
- - Non-sterilized male patients who are sexually active with a female partner of
childbearing potential must use a condom with spermicide from screening to 4 months
after the final dose ofT-DXd.
Complete heterosexual abstinence for the drug washout
period is an acceptable contraceptive method if it is in line with the patient's usual
lifestyle (consideration must be made to the duration of the clinical trial); however,
periodic or occasional abstinence, the rhythm method, and the withdrawal method are
not acceptable. It is strongly recommended for the female partners of a male patient
to also use ≥1 highly effective method of contraception throughout this period, as
described in Table 1. In addition, male patients should refrain from fathering a
child, or freezing or donating sperm from the time of enrollment until 4 months after
the last dose of T-DXd; sperm preservation should be considered prior to enrollment in
this study.
- - Female subjects must not donate, or retrieve for their own use, ova from the time of
enrollment through at least 7 months after the final study drug administration.
Preservation of ova may be considered prior to enrollment in this study.
- - Adequate treatment washout period from prior therapies to allow recovery from any
prior treatment-related toxicities before enrollment in the judgment of the
Investigator.
Table 1: Highly effective methods of contraception (<1% failure rate) Non-Hormonal Methods.
- - Total heterosexual abstinence (evaluate in relation to the duration of the clinical
study and the preferred and usual lifestyle choice of the participant)
- Vasectomised sexual partner (if partner is the sole sexual partner of the trial
participant and that the vasectomised partner has received medical assessment of the
surgical success)
- Bilateral tubal occlusion.
- - Intrauterine device (provided coils are copper banded)
Hormonal Methods.
- - Combined (estrogen and progestogen containing) hormonal contraception associated with
inhibition of ovulation (noting relevant contraindications in ER+ breast cancer, and
risk of DVT in other cancers)
- oral.
- - Progestogen-only hormonal contraception associated with inhibition of ovulation.
- - Intrauterine hormone-releasing system (IUS)
Exclusion Criteria:
- Contraindication or history of allergic reaction to T-DXd.
- - Significant comorbidities as per investigator evaluation.
- - Inability to comply with protocol and/or unwilling or not available for follow up
assessments or any condition which in the investigator's opinion makes the patient
unsuitable for study participation.
- - Ferrous or other contraindication to MR imaging.
- - History of myocardial infarction within 6 months before enrollment.
- - History of symptomatic congestive heart failure (New York Heart Association Class II
to IV)
- Corrected QT interval (QTc) prolongation to >470 ms (females) or >450 ms (male) based
on12-lead electrocardiogram (ECG)
- Subjects with troponin levels above ULN at screening (as defined by the manufacturer),
and without any myocardial related symptoms, should have a cardiologic consultation
before enrollment to rule out MI.
- - History of (noninfectious) interstitial lung disease (ILD)/pneumonitis that required
steroids, has current ILD/pneumonitis, or where suspected ILD/pneumonitis can not be
ruled out by baseline chest CT at Screening.
Lung-specific intercurrent clinically significant illnesses including, but not
limited to, any underlying pulmonary disorder (e.g. pulmonary emboli within three
months of the study enrollment, severe asthma, severe COPD, restrictive lung
disease, pleural effusion etc.)
2. Any autoimmune, connective tissue or inflammatory disorders (e.g. Rheumatoid
arthritis, Sjogren's, sarcoidosis etc.) where there is documented, or a suspicion
of pulmonary involvement at the time of screening.
3. Prior pneumonectomy (complete)
- - Uncontrolled infection requiring IV antibiotics, antivirals, or antifungals.
- - Active primary immunodeficiency, known human immunodeficiency virus (HIV) infection,
or active hepatitis B or C infection.
Patients positive for hepatitis C (HCV) antibody
are eligible only if polymerase chain reaction is negative for HCV RNA.
- - Receipt of live, attenuated vaccine (mRNA and replication deficient adenoviral
vaccines are not considered attenuated live vaccines) within 30 days prior to the
first dose of trastuzumab deruxtecan.
Note: Patients, if enrolled, should not receive
live vaccine during the study and up to 30 days after the last dose of T-DXd.
- - Has unresolved toxicities from previous anticancer therapy, defined as toxicities
(other than alopecia) not yet resolved to Grade ≤ 1 or baseline.
Note: Subjects may be
enrolled with chronic, stable Grade 2 toxicities (defined as no worsening to >Grade 2
for at least 3 months prior to [randomization/enrollment/Cycle 1 Day 1] and managed
with standard of care treatment) that the investigator deems related to previous
anticancer therapy, such as:
1. Chemotherapy-induced neuropathy. 2. Fatigue. 3. Residual toxicities from prior IO treatment: Grade 1 or Grade 2 endocrinopathies
which may include:
i. Hypothyroidism/hyperthyroidism ii. Type 1 diabetes iii. Hyperglycemia iv. Adrenal
insufficiency v. Adrenalitis vi. Skin hypopigmentation (vitiligo)
- - Known allergy or hypersensitivity to study treatment or any of the study drug
excipients.
For patients who are allergic to gadolinium-based agents may receive
premedication as per institutional protocol or imaged without contrast at the
discretion of the Principal Investigator; reactions will be managed per standard
institutional protocol.
- - History of severe hypersensitivity reactions to other monoclonal antibodies.
- - Pregnant or breastfeeding female patients, or patients who are planning to become
pregnant.
- - Patients with substance abuse or any other medical conditions such as clinically
significant cardiac or psychological conditions, that may, in the opinion of the
investigator, interfere with the subject's participation in the clinical study or
evaluation of the clinical study results.
- - Multiple primary malignancies within 3 years, with the exception of:
1.
adequately resected non-melanoma skin cancer. 2. carcinoma in situ of the cervix. 3. Smoldering pre-malignant or malignant conditions with minimal concern for CNS or
extracranial progression during treatment such as CLL or MGUS based on the
assessment of the treating provider. 4. curatively treated in-situ disease. 5. other solid tumors curatively treated. 6. contralateral breast cancer [patients with metastatic breast cancer].
- A pleural effusion, ascites or pericardial effusion that requires drainage, peritoneal
shunt, or Cell-free and Concentrated Ascites Reinfusion Therapy (CART)
