Inclusion Criteria:
- - Males and females of ≥ 18 years of age at the time of signing the informed consent
form (ICF).
- - Subject must understand and voluntarily sign an ICF prior to any study-related
assessments/procedures being conducted.
- - Patients capable of taking oral medication.
- - Subject is willing and able to adhere to the study visit schedule and other protocol
requirements.
- - Histologically confirmed Grade IV GBM/gliosarcoma (WHO criteria; non-IDH R132Hmutant
by immunohistochemistry [IHC] or, sequencing for IDH1 and 2 in case of patients >55
years) established following either a radical or partial surgical resection.
This
includes treatment naïve (chemotherapy and RT) patients with prior histologically
diagnosis of lower-grade astrocytoma that has been upgraded to a histologically
verified glioblastoma after a subsequent definitive surgery.
NOTE: Patients with known isocitrate dehydrogenase (IDH) 1 and 2 are to be excluded.
- - Methylated MGMT according to local laboratory (in case of pyrosequencing, methylation
>10%)
- Subject must have recovered from the effects of surgery, including post-operative
infections or complications.
Toxicities resulting from surgery must have resolved to
NCI CTCAE (v5.0) Grade ≤ 1 prior to starting regorafenib treatment (with the exception
of Grade 2 alopecia).
- - For Concomitant Therapy Cohort: Prior tumor resection up to 7 weeks prior to the first
dose of regorafenib.
- - For Adjuvant Therapy Cohort: Subject must have recently completed standard course of
radiotherapy with TMZ chemotherapy, and then have an MRI documenting stable disease
prior to the first dose of regorafenib (In case of "pseudoprogression" the patient
will not be eligible)
- For Adjuvant Therapy:
1.
All AEs resulting from prior RT+TMZ chemotherapy must have resolved to NCI CTCAE
(v5.0) Grade 1 (except for laboratory parameters outlined below).
2. Subject must have not experienced significant toxicity to prior RT+TMZ (i.e.,
Grade 4 hematological toxicity)
- - Subjects must have life expectancy of at least 6 months.
- - Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1 (or KPS 70)
- Corticosteroid use of dexamethasone 4 mg or less per day within 7 days before starting
regorafenib.
- - Subject must have the following laboratory values at screening within 7 days before
starting regorafenib:
1.
Absolute neutrophil count (ANC) ≥ 1.5 x 109/L without growth factor support for 7
days (14 days if subject received pegfilgrastim).
2. Hemoglobin (Hgb) ≥10 g/dL. 3. Platelet count (plt) ≥100x 109/L. 4. Serum potassium concentration within normal range, or correctable with
supplements. 5. Serum glutamic oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST)
and serum glutamate pyruvic transaminase (SGPT)/alanine aminotransferase (ALT) ≤
3.0 x Upper Limit of Normal (ULN).
6. Serum total bilirubin ≤ 1.5 x ULN. 7. Serum creatinine ≤ 1.5 x ULN or measured glomerular filtration rate (GFR) ≥ 50
mL/min/1.73 m2 using an exogenous filtration marker such as iohexol, inulin, 51Cr
EDTA or 1125 iothalamate, or creatinine clearance of ≥ 50 mL/min using
Cockroft-Gault equation.
8. Serum albumin > 3.5 g/dL. 9. PT (or INR) and APTT within normal range.
- - For women who are not postmenopausal (i.e., < 2 years after last menstruation) or
surgically sterile (absence of ovaries and/or uterus) and who are sexually active:
agreement to use an adequate method of contraception (oral contraceptives,
intrauterine contraceptive device, or barrier method of contraception in conjunction
with spermicidal jelly) during the Treatment period and for at least 6 months after
the last dose of study drug.
- - For male patients who are partners of premenopausal women: agreement to use a barrier
method of contraception during the Treatment period and for at least 6 months after
the last dose of study drug.
Participants with type I diabetes mellitus, hypothyroidism only requiring hormone
replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring
systemic treatment, or conditions not expected to recur in the absence of an external
trigger are eligible to participate.
Exclusion Criteria:
- - Received any prior treatment for glioma including:
1.
Prior prolifeprospan 20 with carmustine wafer.
2. Prior intracerebral agent.
3. Prior radiation treatment for GBM or lower-grade glioma.
4. Prior chemotherapy or immunotherapy for GBM or lower-grade glioma.
5. NOTE: 5-aminolevulinic acid-mediated photodynamic therapy and Flourcrescein
administered prior to surgery to aid in optimal surgical resection is not
considered a chemotherapy agent.
- - Patients who performed biopsy as surgical approach of glioblastoma.
- - Patients who are taking strong cytochrome P (CYP) CYP3A4 inhibitors (eg,
clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir,
posaconazole, ritonavir, saquinavir, telithromycin, voriconazole) or strong CYP3A4
inducers (eg, carbamazepine, phenobarbital, phenytoin, rifampin, St. John's Wort).
- - Patients who are receiving additional, concurrent, active therapy for GBM outside of
the trial.
- - Disease located outside of the brain (e.g. brainstem and leptomeningeal disease).
- - Candidate for urgent palliative intervention for primary disease (e.g., impending
herniation) as judged by the Investigator.
- - History of allergy or hypersensitivity to any of the study treatments or any of their
excipients.
- - In the presence of therapeutic intent to anticoagulate the patient: INR or PT and aPTT
not within therapeutic limits (according to the medical standard in the institution).
NOTE: Per American Society of Clinical Oncology (ASCO) guidelines, use of
low-molecular-weight heparin (LMWH) should be the preferred approach.
- - Unable or unwilling to undergo brain MRI scans with intravenous (IV) gadolinium.
History of another malignancy in the previous 3 years, with a disease-free interval of< 3
years. Patients with prior history of in situ cancer or basal or squamous cell skin cancer
are eligible.
- - Serious, non-healing wound, ulcer, bone fracture, or abscess.
- - Any cerebrovascular accident (including transient ischemic attacks) within the last 6
months prior to initiation of study treatment.
- - Have an ongoing infection with severity of Grade 2 or above (CTCAE 5.0)
- Any hemorrhage or bleeding event that is ≥ Grade 3 based on the National Cancer
Institute (NCI) Common Terminology Criteria for Adverse Event (CTCAE), Grade 2
intracranial hemorrhage, or persistent thrombotic/embolic event within 4 weeks prior
to the start of study medication.
- - Uncontrolled or severe cardiac disease (e.g., history of unstable angina, myocardial
infarction, coronary stenting, or bypass surgery within the last 6 months prior to
initiation of study treatment), symptomatic congestive heart failure, serious
uncontrolled cardiac arrhythmia (including atrial flutter/fibrillation), requirement
for inotropic support or use of devices for cardiac conditions (e.g.,
pacemakers/defibrillators), or hypertension (participants with systolic blood
pressure[BP] of > 160 mmHg or diastolic BP of > 100 mmHg despite optimal medical
management are to be excluded).
- - History of interstitial lung disease, history of slowly progressive dyspnea and
unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary
hypersensitivity pneumonitis, or symptomatic pleural effusion.
- - Active, known, or suspected auto-immune disease, including systemic lupus
erythematosus, Hashimotos thyroiditis, scleroderma, polyarteritis nodosa, or
auto-immune hepatitis.
- - Known history of hepatitis B, human immunodeficiency virus (HIV), or active hepatitis
C infection requiring treatment with antiviral therapy.
Note: HIV testing is not
required in the absence of clinical suspicion.
- - History of bleeding diathesis (irrespective of severity).
- - Uncontrolled intercurrent illness including (e.g., symptomatic ascites), but not
limited to ongoing or active infection.
- - Persistent ≥ Grade 3 Lipase (> 2.0 - 5.0 x upper limit of normal [ULN] with signs or
symptoms; > 5.0 x ULN and asymptomatic).
- - Persistent proteinuria> 3.5 g/24 hours measured by urine protein creatinine ratio from
a random urine sample (≥ Grade 3, CTCAE 5.0)
- Have any malabsorbition condition.
- - Any condition that could make the subject noncompliant with the study procedures
and/or study requirements, as judged by the Investigator (for example: cognitive
impairment, psychiatric illness, etc).
