Clinical Trial Finder

Inclusion Criteria:

• - Patients must have met applicable eligibility criteria in the Master MATCH Protocol EAY131/ NCI-2015-00054 prior to registration to treatment subprotocol.

• - Patients must fulfill all eligibility criteria of MATCH Master Protocol at the time of registration to treatment step (Step 1, 3, 5, 7) - Patients must have a mutation in mTOR, KEAP1 or NFE2L2 as determined via the MATCH Master Protocol.

• - Patients must have an electrocardiogram (ECG) within 8 weeks prior to treatment assignment and must NOT have any of the following cardiac criteria: - Clinically important abnormalities in rhythm, conduction or morphology of resting ECG (e.g. complete left bundle branch block, third degree heart block, Corrected QT Interval [QTc] interval > 480 milliseconds) - Uncontrolled hypertension (i.e., systolic blood pressure >180 mm Hg, diastolic blood pressure > 95 mm Hg).

Use of anti-hypertensive agents to control hypertension before cycle 1, day 1 is allowed.

• - Known pulmonary hypertension.

• - Patients must not have known hypersensitivity to MLN0128 or compounds of similar chemical or biologic composition.

• - Patients must not have known hepatitis B surface antigen-positive, or known or suspected active hepatitis C infection, but may have had previously treated and successfully eradicated hepatitis C virus (HCV) - Patients must have none of the following within six months of receiving the first dose of MLN0128 (TAK-228): ischemic, myocardial or cerebrovascular event, class III or IV heart failure, placement of pacemaker, or pulmonary embolism.

• - Patients must have no manifestations of malabsorption due to prior gastrointestinal (GI) surgery, GI disease, or for an unknown reason that may alter the absorption of MLN0128 (TAK-228) - Patients who have a history of brain metastasis are eligible for the study provided that all the following criteria are met: - Brain metastases which have been treated.

• - No evidence of disease progression for >= 1 months before the first dose of study drug.

• - No hemorrhage after treatment.

• - Off-treatment with dexamethasone for 4 weeks before administration of the first dose of MLN0128 (TAK-228) - No ongoing requirement for dexamethasone or anti-epileptic drugs.

• - Patients meeting the following criteria for concomitant medications prior to starting MLN0128 (TAK-228) are not eligible for the study: - Patients who use a proton pump inhibitor (PPI) within 7 days before receiving the first dose of study drug.

• - Patients who would require treatment with PPIs throughout the trial.

• - Patients who would need to take H2 receptor antagonists within 24 hours of the first dose of study drug NOTE Strong CYP1A2 inhibitors and CYP inducers should be administered with caution, at the discretion of the investigator.

Alternative treatments, if available, should be considered.

• - Patients must not have known treatment with systemic corticosteroid within one week prior to the first administration of study drug.

• - Patients must not have uncontrolled diabetes mellitus.

Controlled diabetes is defined as: Glycosylated hemoglobin (HbA1c) < 7.0%, or fasting serum glucose (=< 130 mg/dL)

• - Patients must not have fasting triglycerides >= 300 mg/dL.

• - Patients must not have had prior treatment with other known TORC1/2 inhibitors, including: - AZD8055.

• - XL765.

• - BEZ235.

• - GSK2126458.

• - XL388.

• - DS3078(a) - PF-05212384.

• - SF1126.

• - Palomid-529.

• - GDC0980 (apitolisib) - LY30223414.

• - BKM120.

• - OSI0127.

• - MLN0128 (TAK-228) - AZD2014.

• - Patients must not have other clinically significant co-morbidities that, in the opinion of the investigator, would limit compliance with study requirements.

• - Fertility and developmental studies with MLN0128 (TAK-228) have not been conducted.

On the basis of potential hazard of other mTOR inhibitors (i.e., rapamycin and other rapalogs) on the developing fetus, women of childbearing age should avoid becoming pregnant while taking MLN0128 (TAK-228). For this reason, women of child-bearing potential and men must agree to practice 1 highly effective method of contraception and 1 additional effective (barrier) method of contraception, at the same time, from the time of signing the informed consent through 120 days after the last dose of study drug, or agree to completely abstain from heterosexual intercourse. Men must agree not to donate sperm during the course of this study or within 120 days after receiving their last dose of study drug. - Patients who are known to be HIV-positive are not eligible for this study

PRIMARY OBJECTIVE:

• I. To evaluate the proportion of patients with objective response (OR) to targeted study agent(s) in patients with advanced refractory cancers/lymphomas/multiple myeloma.

SECONDARY OBJECTIVES:

• I. To evaluate the proportion of patients alive and progression free at 6 months of treatment with targeted study agent in patients with advanced refractory cancers/lymphomas/multiple myeloma.

• II. To evaluate time until death or disease progression.

• III. To identify potential predictive biomarkers beyond the genomic alteration by which treatment is assigned or resistance mechanisms using additional genomic, ribonucleic acid (RNA), protein and imaging-based assessment platforms.

• IV. To assess whether radiomic phenotypes obtained from pre-treatment imaging and changes from pre- through post-therapy imaging can predict objective response and progression free survival and to evaluate the association between pre-treatment radiomic phenotypes and targeted gene mutation patterns of tumor biopsy specimens.

OUTLINE: Patients receive sapanisertib (MLN0128 [TAK-228]) orally (PO) once daily (QD) on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo computed tomography (CT) or magnetic resonance imaging (MRI) during screening and on study, as well as during follow-up as clinically necessary. Patients also undergo biopsies and blood sample collection on study. After completion of study treatment, patients are followed every 3 months for 2 years and then every 6 months for 1 year.

Arms

Experimental: Treatment (sapanisertib [MLN0128 (TAK-228)])

Patients receive sapanisertib (MLN0128 [TAK-228]) PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients also undergo biopsies and blood sample collection on study.

Interventions

Procedure: - Biopsy

Undergo biopsy

Procedure: - Biospecimen Collection

Undergo blood sample collection

Procedure: - Computed Tomography

Undergo CT scan

Procedure: - Magnetic Resonance Imaging

Undergo MRI

Drug: - Sapanisertib

Given PO